| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日)
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| 2. | 徳島大学.歯学部.歯学科
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| ○著者 (必須): | 1. | (英) Amano Ichiro (日) 天野 伊知郎 (読) あまの いちろう
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| 2. | 石川 康子
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| 3. | (英) Ishida Hajie (日) 石田 甫 (読) いしだ はじめ
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| ○題名 (必須): | □ | (英) Regulation of phosphorylation of Gi2αprotein controls the secretory response to isoproterenol in rat parotid tissues. (日)
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| ○要約 (任意): | □ | (英) Treatment of rat parotid tissues with 1 microM isoproterenol (IPR) for 10 min caused a 60% decrease in pertussis toxin (IAP)-catalyzed ADP-ribosylation of Gi alpha and resulted in supersensitivity of amylase secretion from the tissues. However, conversely, IPR treatment for 30 min caused a 40% increase in IAP-catalyzed ADP-ribosylation of Gi alpha, coupled with desensitization of amylase secretion. No changes in Gs function were observed in IPR-induced phenomena. Pretreatment with okadaic acid induced enhancement of the supersensitivity of amylase secretion and disappearance of the desensitization. These phenomena were accompanied with decreases in IAP-catalyzed ADP-ribosylation of Gi alpha. IPR treatment for 30 min caused a 50% decrease in phosphorylation of Gi2 alpha immunoprecipitated with anti-G protein antiserum (AS/7) from [32P]Pi-labeled cells, but such treatment for 10 min caused a 40% increase in phosphorylation in the cells pretreated with okadaic acid. Phosphorylation and dephosphorylation of immunoprecipitates with AS/7 by protein kinase A (PKA) and alkaline phosphatase caused decreases and increases in IAP-catalyzed ADP-ribosylation, respectively, indicating the presence of PKA-mediated phosphorylation sites on Gi2 alpha. Thus, the control of the phosphorylation of Gi2 alpha is of importance and relevance in the regulation of biological processes and cellular responses. (日)
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| ○キーワード (推奨): | 1. | 顎口腔機能 (stomatognathic function)
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| 2. | 情報伝達機構 (signal transduction)
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| 3. | 神経伝達物質 (neurotransmitter)
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| 4. | リン酸化 (phosphorylation)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ([Elsevier Science])
(pISSN: 0167-4889)
| ○ISSN (任意): | □ | 0167-4889
ISSN: 0167-4889
(pISSN: 0167-4889, eISSN: 1879-2596) Title: Biochimica et biophysica acta. Molecular cell researchTitle(ISO): Biochim Biophys Acta Mol Cell ResPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 1313
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 146 156
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1996年 8月 28日 (平成 8年 8月 28日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/0167-4889(96)00060-2 (→Scopusで検索)
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| ○PMID (任意): | □ | 8781562 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-0030604822
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| ○備考 (任意): | 1. | (英) Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (日)
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