| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日)
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| 2. | 徳島大学.歯学部.歯学科
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| ○著者 (必須): | 1. | 石川 康子
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| 2. | (英) Takafumi Eguchi (日) 江口 貴文 (読) えぐち たかふみ
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| 3. | (英) Hajime Ishida (日) 石田 甫 (読) いしだ はじめ
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| ○題名 (必須): | □ | (英) Mechanism of β-adrenergic agonist-induced transmural transport of glucose in rat small intestine: Reguration of phosphorylation of SGLT1 controls the function. (日)
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| ○要約 (任意): | □ | (英) The perfusion of rat small intestine with 10 microM epinephrine (Epi) or 10 microM norepinephrine resulted in significant increases in the amount of 3-O-[methyl-3H]-D-glucose transported from the mucosal to serosal side. The Epi-induced increases in glucose transport were coupled with selective increases in beta-adrenoceptor density in the mucosal membranes. Treatment with 0.1 microM okadaic acid increased glucose transport even in the absence of Epi, but that with 1 microM staurosporine or 60 microM N-[2-(methylamino)ethyl]-5-isoquinoline-sulfonamide dihydrochloride completely inhibited the increases in glucose transport induced by 10 microM Epi or 10 microM dibutyryl cAMP. The maximal binding sites (Bmax) of [3H]phlorizin in brush border membrane (BBM) from tissues perfused with Epi was increased, showing increases in the binding ability of the Na+/glucose cotransporter (SGLT1) to glucose. Phosphorylation and dephosphorylation of BBM with protein kinase A (PKA) and alkaline phosphatase resulted in increases and decreases in Bmax of [3H]phlorizin, respectively. The phosphorylation state of SGLT1 immunoprecipitated from BBM incubated with [gamma-32P]ATP-Mg2+ and PKA, and the analysis of phosphoamino acids composed of SGLT1 in rats given [32P]orthophosphate indicate the presence of potential sites for PKA-mediated phosphorylation of SGLT1 at serine. These findings indicate that the regulation of phosphorylation of SGLT1 leads to an alteration of its function and results in the control of glucose transport in the rat small intestine. (日)
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| ○キーワード (推奨): | 1. | 情報伝達機構 (signal transduction)
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| 2. | 神経伝達物質 (neurotransmitter)
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| 3. | (英) Autonomic nerve (日) 自律神経 (読) じりつしんけい
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| 4. | (英) absorption (日) 吸収 (読) きゆうしゅう
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ([Elsevier Science])
(pISSN: 0167-4889)
| ○ISSN (任意): | □ | 0167-4889
ISSN: 0167-4889
(pISSN: 0167-4889, eISSN: 1879-2596) Title: Biochimica et biophysica acta. Molecular cell researchTitle(ISO): Biochim Biophys Acta Mol Cell ResPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 1357
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 306 318
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1997年 7月 24日 (平成 9年 7月 24日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/S0167-4889(97)00043-8 (→Scopusで検索)
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| ○PMID (任意): | □ | 9268055 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (日)
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