| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日)
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| 2. | 徳島大学.歯学部.歯学科
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| ○著者 (必須): | 1. | (英) Eguchi Takafumi (日) 江口 貴文 (読) えぐち たかふみ
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| 2. | 石川 康子
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| 3. | (英) Ishida Hajime (日) 石田 甫 (読) いしだ はじめ
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| ○題名 (必須): | □ | (英) Mechanism underlying histamine-induced desensitization of amylase secretion in rat parotid glands. (日)
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| ○要約 (任意): | □ | (英) 1. Histamine acted on H2 receptors in rat parotid tissues and induced the amylase secretion. Immunoblot analysis by using anti-H2 receptor protein antiserum demonstrated that histamine induced the increase and decrease in the amounts of H2 receptor proteins in basolateral and intracellular membranes, respectively. 2. Short-term treatment with histamine resulted in decreases in amylase secretion, the density of H2 receptors and their affinity for the agonists during further incubation with histamine, but showed an unaltered secretory response to isoproterenol, indicating that the histamine-induced desensitization was confined to H2 receptors. 3. This treatment triggered a 20% decrease in the histamine-stimulated adenylate cyclase activity and a 40% decrease in the phosphorylation level of Gi2alpha protein in the tissues, resulting in an increase in pertussis toxin (IAP)-catalyzed ADP-ribosylation of the protein. An enhancement of cholera toxin-catalyzed ADP-ribosylation of Gs protein was observed only during the first incubation with histamine. 4. This treatment triggered a 30% decrease and a 60% increase in the histamine-stimulated activities of protein kinase A and protein phosphatase 2A in the tissues, respectively. 5. Pretreatment with okadaic acid completely blocked the histamine-induced decrease in amylase secretion and increase in IAP-catalyzed ADP-ribosylation of Gi protein. The levels of Gi2alpha and Gs alpha proteins in the tissues were not modified by histamine treatment and the level of Gi2alpha protein was not affected by pretreatment with okadaic acid, as assessed by immunoblot analyses with anti-Gi2alpha and anti-Gs alpha protein antiserum. 6. The regulation of Gi2alpha protein phosphorylation in parotid tissues plays an important role in the histamine-induced desensitization of amylase secretion. (日)
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| ○キーワード (推奨): | 1. | 顎口腔機能 (stomatognathic function)
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| 2. | 情報伝達機構 (signal transduction)
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| 3. | 神経伝達物質 (neurotransmitter)
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| 4. | ヒスタミン (histamine)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | British Journal of Pharmacology (British Pharmacological Society)
(pISSN: 0007-1188, eISSN: 1476-5381)
| ○ISSN (任意): | □ | 0007-1188
ISSN: 0007-1188
(pISSN: 0007-1188, eISSN: 1476-5381) Title: British journal of pharmacologyTitle(ISO): Br J PharmacolSupplier: British Pharmacological SocietyPublisher: Wiley Publishing (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 124
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 1523 1533
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1998年 8月 初日 (平成 10年 8月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/sj.bjp.0701981 (→Scopusで検索)
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| ○PMID (任意): | □ | 9723967 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-0031829641
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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