| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日)
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| ○著者 (必須): | 1. | 石川 康子
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| 2. | (英) Skowronski, T. Mariusz (日) (読)
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| 3. | (英) Inoue Noriko (日) 井上 紀子 (読) いのうえ のりこ
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| 4. | (英) Ishida Hajime (日) 石田 甫 (読) いしだ はじめ
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| ○題名 (必須): | □ | (英) α1-Adrenoceptor-induced trafficking of aquaporin-5 to the apical plasma membrane of rat parotid cells. (日)
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| ○要約 (任意): | □ | (英) Incubation of rat parotid tissue with 10 microM epinephrine resulted in a transient and marked trafficking of aquaporin-5 (AQP5) from intracellular membranes to the apical plasma membrane (APM) that was maximal at 1 min. This effect of epinephrine was mimicked by phenylephrine, but not by clonidine, dobutamine, or salbutamol, and it was inhibited by phentolamine, but not by propranolol. Furthermore, the epinephrine-induced trafficking of AQP5 was inhibited by phospholipase C inhibitor U73122 as well as dantrolene and TMB-8, both of which inhibit the release of Ca(2+) from intracellular stores. Cytochalasin D and tubulozole-C also inhibited this action of epinephrine. These results indicate that epinephrine, acting at alpha(1)-adrenoceptors, induces the trafficking of AQP5 to the APM by triggering the release of Ca(2+) from intracellular stores through inositol 1,4,5-trisphosphate and ryanodine receptors. In addition, the potent involvement of the cytoskeleton was shown in the epinephrine-induced trafficking of AQP5. (日)
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| ○キーワード (推奨): | 1. | 顎口腔機能 (stomatognathic function)
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| 2. | 情報伝達機構 (signal transduction)
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| 3. | 神経伝達物質 (neurotransmitter)
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| 4. | カルシウム (calcium)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)
| ○ISSN (任意): | □ | 0006-291X
ISSN: 0006-291X
(pISSN: 0006-291X, eISSN: 1090-2104) Title: Biochemical and biophysical research communicationsTitle(ISO): Biochem Biophys Res CommunPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 265
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 94 100
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1999年 11月 11日 (平成 11年 11月 11日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1006/bbrc.1999.1630 (→Scopusで検索)
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| ○PMID (任意): | □ | 10548496 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-0033547393
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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