| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Kita, Y. (日) (読)
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| 2. | (英) Funakoshi, F. (日) (読)
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| 3. | (英) Yoshida, S. (日) (読)
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| 4. | (英) Tanaka, M. (日) (読)
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| 5. | (英) Kurokohchi, K. (日) (読)
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| 6. | (英) Uchida, N. (日) (読)
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| 7. | (英) Watanabe, S. (日) (読)
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| 8. | 松本 耕三
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| 9. | (英) Kuriyama, S. (日) (読)
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| ○題名 (必須): | □ | (英) Expression of G1 phase-related cell cycle molecules in naturally developing hepatocellular carcinoma of Long-Evans Cinnamon rats. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) It has been shown that a variety of cell cycle-related proteins play important roles in the process of carcinogenesis including hepatocarcinogenesis. In the present study, we evaluated mRNA and protein expression of G1 phase-related cell cycle molecules in the process of hepatocarcinogenesis, using Long-Evans Cinnamon (LEC) rats, an animal model of hepatocellular carcinoma (HCC). The expression of cyclin D1, cyclin-dependent kinase 4 (Cdk4) and Cdk6 was measured quantitatively by real-time polymerase chain reaction. Cyclin D1 mRNA expression was increased significantly in chronic hepatitis liver compared with normal liver, and then decreased in HCC and the surrounding precancerous liver of LEC rats. Levels of Cdk4 mRNA were increased significantly in HCC compared to precancerous and chronic hepatitis livers. In contrast, mRNA levels of Cdk6 did not change significantly during hepatocarcinogenesis. We also evaluated the protein levels of these G1 phase-related cell cycle molecules by Western blot analyses and confirmed similar results. Total amounts of retinoblastoma protein (pRb) in the liver did not change significantly in the process of hepatocarcinogenesis in LEC rats. However, levels of phosphorylated pRb were increased markedly in the process of hepatocarcinogenesis, and the highest in HCC compared to precancerous, chronic hepatitis and normal livers. These results indicate that cyclin D1 may be involved in the regeneration of hepatocytes rather than hepatocarcinogenesis, while Cdk4 but not Cdk6 may play an important role in the development of HCC. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Carcinoma, Hepatocellular (日) (読)
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| 3. | (英) Cell Cycle Proteins (日) (読)
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| 4. | (英) Cyclin D1 (日) (読)
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| 5. | (英) Cyclin-Dependent Kinase 4 (日) (読)
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| 6. | (英) Cyclin-Dependent Kinase 6 (日) (読)
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| 7. | (英) Cyclin-Dependent Kinases (日) (読)
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| 8. | (英) G1 Phase (日) (読)
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| 9. | (英) Hepatitis, Animal (日) (読)
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| 10. | (英) Hepatitis, Chronic (日) (読)
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| 11. | (英) Liver Cirrhosis (日) (読)
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| 12. | (英) Liver Neoplasms, Experimental (日) (読)
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| 13. | (英) Phosphorylation (日) (読)
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| 14. | (英) Proto-Oncogene Proteins (日) (読)
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| 15. | (英) RNA, Messenger (日) (読)
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| 16. | (英) Rats (日) (読)
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| 17. | (英) Rats, Inbred LEC (日) (読)
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| 18. | (英) Retinoblastoma Protein (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Journal of Oncology (International Center for Cancer Research)
(pISSN: 1019-6439, eISSN: 1791-2423)
| ○ISSN (任意): | □ | 1019-6439
ISSN: 1019-6439
(pISSN: 1019-6439, eISSN: 1791-2423) Title: International journal of oncologyTitle(ISO): Int J OncolPublisher: Spandidos Publications (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 24
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 1205 1211
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2004年 5月 初日 (平成 16年 5月 初日)
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| ○URL (任意): |
| ○DOI (任意): |
| ○PMID (任意): | □ | 15067343 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000220779700018
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Third Department of Internal Medicine, Kagawa University School of Medicine, Kagawa 761-0793, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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