『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
〔閲覧〕【著作】
--- テーブル「著作」（著作（著書，論文，レター，国際会議など））は研究業績にかかる著作（著書，論文，レター，国際会議など）を登録するテーブルです．
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抽出条件
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| REF= |  大髙 章 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.機能分子合成薬学])
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登録情報の数
有効な情報: 240件 + 無効な情報: 4件 = 全ての情報: 244件
全ての有効な情報 (240件)
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抽出結果のリスト
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排列順: 項目表示: 大髙 章, 藤井 信孝 : シスチン含有ペプチドの新規合成法, 有機合成化学協会誌, Vol.48, (号), 658-671, 1990年7月..[著者] ... 大髙 章, 藤井 信孝 : ペプチド合成における最終脱保護材, 有機合成化学協会誌, Vol.48, (号), 1044-1045, 1990年11月..[著者] ... 大髙 章, 藤井 信孝 : ジスルフィド結合形成材, 有機合成化学協会誌, Vol.48, (号), 1010-1011, 1990年11月..[著者] ... 木曽 良明, 大髙 章 : 続 医薬品の開発 第14巻, --- ペプチド合成 ---, 株式会社 廣川書店, 東京, 1991年(0月)..[著者] ... 藤井 信孝, 大髙 章 : 新生化学実験講座1 タンパク質6, --- 合成および発現 ---, 株式会社 東京化学同人, 東京, 1992年6月..[著者] ... Akira Otaka, Kengo Miyoshi, Midori Kaneko, Hirokazu Tamamura, Nobutaka Fujii, Motoyoshi Nomizu, Terrence R. Burke and Peter P. Roller : Development of Efficient Two-Step Deprotection Methodology for Dimethyl-Protected Phosphoamino Acid-Containing Peptide Resins and Its Application to the Practical Synthesis of Phosphopeptides, The Journal of Organic Chemistry, Vol.60, (号), 3967-3974, 1995..[著者] ... Kazuo Nakai, Toshiro Ibuka, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii and Yoshinori Yamamoto : A One-pot Aza-Payne Rearrangement-Epoxide Ring Opening Reaction of 2-Aziridinemethanols: A Regio- and Stereoselective Synthetic Route to Diastereomerically Pure 1,2-Amino Alocohols., Tetrahedron Letters, Vol.36, (号), 6247-6250, 1995..[著者] ... Nobutaka Fujii, Kazuo Nakai, Hirokazu Tamamura, Akira Otaka, Norio Mimura, Yoshihisa Miwa, Tooru Taga, Yoshinori Yamamoto and Toshiro Ibuka : SN2' Ring opening of aziridines bearing an α,β-unsaturated ester group with organocopper reagents. A new stereoselective synthetic route to (E)-alkene dipeptide isosteres., Journal of the Chemical Society, Perkin Transactions 1, (巻), (号), 1359-1371, 1995..[著者] ... Toshiro Ibuka, Kazuo Nakai, Hiromu Habashita, Yuka Hotta, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii, Norio Mimura, Yoshihisa Miwa, Tooru Taga, Yukiyasu Chounan and Yoshinori Yamamoto : Aza-Payne Rearrangement of Activated 2-Aziridinemethanols and 2,3-Epoxy Amines under Basic Conditions., The Journal of Organic Chemistry, Vol.60, No.7, 2044-2058, 1995..[著者] ... Nobutaka Fujii, Kazuo Nakai, Hiromu Habashita, Akira Otaka, Toshiro Ibuka, N Wada, Ryuichiro Doi, Ryo Hosotani, Masayuki Imamura, F Garrido, A Mann, Yukiyasu Chounan and Yoshinori Yamamoto : Highly Stereoselective Synthesis of (E)-Alkene Dipeptide Isosters via Organocopper Mediated 1,3-Chirality Transfer Reaction and Its Application to The Synthesis of Potent Bombesin Antagonist with No Agonistic Activity, Peptide 1994, (巻), (号), 77-78, 1995..[著者] ... Akira Otaka, Kengo Miyoshi, Terrence R. Burke-Jr, Peter P. Roller, Hirokazu Tamamura and Nobutaka Fujii : Synthesis and Biological Activity of Phosphatases Resistant Phosphoamino Acid Mimetics Containing Peptides, Peptide Chemistry 1994, (巻), (号), 9-12, 1995..[著者] ... Hirokazu Tamamura, Y Terakawa, Masao Masuda, Akira Otaka, H Murakami, Hideki Nakashima, S Horiuchi, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Structure-Activity Relationships of An Anti-HIV Peptide, T-22(No.2), Peptide Chemistry 1994, (巻), (号), 153-156, 1995..[著者] ... K. Suzuki, Toshiro Ibuka, Tooru Taga, Yoshihisa Miwa, Norio Mimura, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of L-Vinylglycine Derivatives, Peptide Chemistry 1994, (巻), (号), 165-168, 1995..[著者] ... Akira Otaka, Kengo Miyoshi, Terrence R. Burke-Jr, Peter P. Roller, Hirokazu Tamamura and Nobutaka Fujii : Application of Ser(OPO3Me2) Derivatives to The Synthesis of Phosphoserine-containing peptide, Peptide Chemistry 1994, (巻), (号), 193-196, 1995..[著者] ... Akira Otaka, Kengo Miyoshi, Peter P. Roller, Terrence R. Burke-Jr, Hirokazu Tamamura and Nobutaka Fujii : Practical Synthesis of Phosphopeptides Using Dimethyl-protected Phosphoamino Acid Derivatives., Journal of the Chemical Society. Chemical Communications, Vol.3, (号), 387-389, 1995..[著者] ... Hirokazu Tamamura, Akira Otaka, W Takada, Y Terakawa, H Yoshizawa, Masao Masuda, Toshiro Ibuka, Tsutomu Murakami, Hideki Nakashima, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Solution-phase synthesis of an anti-human immunodeficiency virus peptide, T22 ([Tyr5,12,Lys7]-polyphemusin II), and the modification of Trp by the p-methoxybenzyl group of Cys during trimethylsilyl trifluoromethanesulfonate deprotection., Chemical & Pharmaceutical Bulletin, Vol.43, No.1, 12-18, 1995..[著者] ... Ronald L. Wange, Noah Isakov, Terrence Burke R. Jr., Akira Otaka, Peter P. Roller, Julian D. Watts, Ruedi Aebersold and Lawrence E. Samelson : F2(Pmp)2-TAM3, a Novel Competitive Inhibitor of the Binding of ZAP-70 to the T Cell Antigen Receptor, Blocks Early T Cell Signaling, The Journal of Biological Chemistry, Vol.270, No.2, 944-948, 1995..[著者] ... Akira Otaka, Kengo Miyoshi, Hideki Kubota, Terrence R. Burke-Jr, Peter P. Roller, Hirokazu Tamamura and Nobutaka Fujii : Synthesis and application of N-Boc-L-2-amino-4-(diethylphosphono)-4,4-difluorobutanoic acid for solid-phase synthesis of nonhydrolyzable phosphoserine peptide analogues, Tetrahedron Letters, Vol.36, No.6, 927-930, 1995..[著者] ... Hirokazu Tamamura, Akira Otaka, J Nakamura, K Okubo, T Koide, K Ikeda, Toshiro Ibuka and Nobutaka Fujii : Disulfide Bond-forming Reaction using Dimethyl sulfoxide/aqueous HCl System and Its Application to Regioselective Two Disulfide Bond Formation., International Journal of Peptide and Protein Research, Vol.45, No.4, 312-319, 1995..[著者] ... Hirokazu Tamamura, Tsutomu Murakami, S Horiuchi, K Sugihara, Akira Otaka, W Takada, Toshiro Ibuka, Michinori Waki, Naoki Yamamoto and Nobutaka Fujii : Synthesis of Protegrin-related Peptides and their Antibacterial and Anti-Human Immunodeficiency Virus Activity., Chemical & Pharmaceutical Bulletin, Vol.43, No.5, 853-858, 1995..[著者] ... Hirokazu Tamamura, K Sugihara, Akira Otaka, Tsutomu Murakami, S Horiuchi, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Synthesis of Protegrin-related Peptides and their Antibacterial and Anti-HIV Activity., Peptide Chemistry 1994, (巻), (号), 345-348, 1995..[著者] ... Motoyoshi Nomizu, W H. Kim, Keizo Yamamura, Atsushi Utani, Sang-Yong Song, Akira Otaka, Peter P. Roller, Hynda K. Kleinman and Yoshihiko Yamada : Identification of Cell Binding Sites in the Laminin a1 Chain Carboxyl-terminal Globular Domain by Systematic Screening of Synthetic Peptides., The Journal of Biological Chemistry, Vol.270, No.35, 20583-20590, 1995..[著者] ... Li Chen, Li Wu, Akira Otaka, Mark S Smyth, Peter P Roller, Terrence R Burke, Den Jen Hertog and Zhong-Yin Zhang : Why Is Phosphonodifluoromethyl Phenylalanine a More Potent Inhibitory Moiety Than Phosphonomethyl Phenylalanine Toward Protein-Tyrosine Phosphatases, Biochemical and Biophysical Research Communications, Vol.216, No.3, 976-984, 1995..[著者] ... Bin Ye, Akira Otaka and Terrence R. Burke-Jr : Preparation of Na-Boc 4-O-Diethylphosphono-L-azatyrosine, a Reagent Potentially Useful for the Synthesis of Signal Transduction Related Peptides., Synlett, (巻), (号), 459-460, 1996..[著者] ... Akira Otaka, Kengo Miyoshi, Hirokazu Tamamura, Peter P. Roller, Terrence R. Burke-Jr and Nobutaka Fujii : Development of a Practical Synthetic Methodology Using Dimethylphosphono Amino Acid for Phosphopeptides, Peptides: Chemistry, Structure and Biology, (巻), (号), 442-443, 1996..[著者] ... Motoyoshi Nomizu, Atsushi Utani, Akira Otaka, Peter P. Roller and Yoshihiko Yamada : Assembly and Stability of Double- and Triple-stranded α-Helical Coiled-coil Structures of Laminin Peptides, Peptides: Chemistry, Structure and Biology, (巻), (号), 487-488, 1996..[著者] ... Kengo Miyoshi, Akira Otaka, Midori Kaneko, Hirokazu Tamamura and Nobutaka Fujii : Practical Phosphopeptides Synthesis Using Dimethylphosphono Amino Acids (No.2), Peptide Chemistry 1995, (巻), (号), 25-28, 1996..[著者] ... Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Identification of Binding Proteins of an Anti-HIV Peptide,T22, Peptide Chemistry 1995, (巻), (号), 237-240, 1996..[著者] ... W Takada, Akira Otaka, Kazuo Nakai, Toshiro Ibuka, Koji Fujimoto, M Wada, Ryuichiro Doi, Ryo Hosotani, S Higashide, Masayuki Imamura and Nobutaka Fujii : Synthesis and Biological Activity of Bombesin Analogues Containing (E)-Alkene Dipeptide Isosteres, Peptide Chemistry 1995, (巻), (号), 493-496, 1996..[著者] ... Joseph J. Barchi-Jr, Motoyoshi Nomizu, Akira Otaka, Peter P. Roller and Terrence R. Burke-Jr : Conformational Analysis of Cyclic Hexapeptides Designed as Constrained Ligands for the SH2 Domain of the p85 Subunit of Phosphatidylinositol-3-OH Kinase., Biopolymers, Vol.38, No.2, 191-208, 1996..[著者] ... Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Tsunehito Ishihara, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Interaction of an Anti-HIV Peptide, T22, with GP120 and CD4, Biochemical and Biophysical Research Communications, Vol.219, No.2, 555-559, 1996..[著者] ... Motoyoshi Nomizu, Atsushi Utani, Konrad Beck, Akira Otaka, Peter P. Roller and Akira Otaka : Mechanism of Laminin Chain Assembly into a Triple-Stranded Coiled-Coil Structure, Biochemistry, Vol.35, No.9, 2885-2893, 1996..[著者]+[著者] ... Hirokazu Tamamura, Tsunehito Ishihara, Akira Otaka, Tsutomu Murakami, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Analysis of the interaction of an anti-HIV peptide, T22 ([Tyr5, 12, Lys7]-polyphemusin II), with gp120 and CD4 by surface plasmon resonance, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol.1298, No.1, 37-44, 1996..[著者] ... Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Toshiro Ibuka, Kyoko Sakano, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : An Anti-HIV Peptide, T22, Forms a Highly Active Complex with Zn(II), Biochemical and Biophysical Research Communications, Vol.229, No.2, 648-652, 1996..[著者] ... Hirokazu Tamamura, Masaki Yamashita, Hiroyuki Muramatsu, Hiroaki Ohno, Tohiro Ibuka, Akira Otaka and Nobutaka Fujii : Regiospecific ring-opening reactions of aziridines bearing an α,β-unsaturated ester group with trifluoroacetic acid or methanesulfonic acid: application to the stereoselective synthesis of (E)-alkene dipeptide isosteres, Chemical Communications, (巻), (号), 2327-2328, 1997..[著者] ... 大髙 章 : タンパク質化学 第11巻, --- ホルモン系タンパク質およびポリアミン ---, 株式会社 廣川書店, 東京, 1997年(0月)..[著者] ... Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Identification of a Polyphemusin Analog (T22)- Zn(II) complex by Mass Spectrometric Analysis and Its Anti-HIV Activity, Peptide Chemistry 1996, (巻), (号), 269-272, 1997..[著者] ... Hiroaki Ohno, Norio Mimura, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii, Toshiro Ibuka, Isao Shimizu, Akiharu Satake and Yoshinori Yamamoto : Palladium-Catalyzed Reductive Ring Opening with Formic Acid of Aziridines Bearing an α,β-Unsaturated Ester Group, Tetrahedron, Vol.53, No.38, 12933-12946, 1997..[著者] ... Hiroshi Aoyama, Norio Mimura, Hiroaki Ohno, Kiyonori Ishii, Ayako Toda, Hirokazu Tamamura, Akira Otaka, Nobutaka Fujii and Toshiro Ibuka : Regio- and stereoselectivity in reactions of 2,3-cis- and trans-3-alkyl-2-vinylaziridines with organocopper reagents: Importance of 2,3-cis-stereochemistry in controlling selectivity, Tetrahedron Letters, Vol.38, No.42, 7383-7386, 1997..[著者] ... Motoyoshi Nomizu, Yuichiro Kuratomi, Sang-Yong Song, M. Lourdes Ponce, Matthew P. Hoffman, Sharon K. Powell, Kengo Miyoshi, Akira Otaka, Hynda K. Kleinman and Yoshihiko Yamada : Identification of Cell Binding Sequences in Mouse Laminin 1 Chain by Systematic Peptide Screening, The Journal of Biological Chemistry, Vol.272, No.51, 32198-32205, 1997..[著者] ... Hirokazu Tamamura, Tsunehito Ishihara, Hiromi Oyake, Makoto Imai, Akira Otaka, Toshiro Ibuka, Rieko Arakaki, Hideki Nakashima, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Convenient one-pot synthesis of cystine-containing peptides using the trimethylsilyl chloride dimethyl sulfoxide/trifluoroacetic acid system and its application to the synthesis of bifunctional anti-HIV compounds1, Journal of the Chemical Society, Perkin Transactions 1, (巻), (号), 495-500, 1998..[著者] ... Hirokazu Tamamura, F Matsumoto, Kyoko Sakano, Akira Otaka, Toshiro Ibuka and Nobutaka Fujii : Unambiguous Synthesis of Stromal Cell-derived Factor-1 by Regioselective Disulfide Bond Formation Using a DMSO-aqueous HCl System, Chemical Communications, (巻), No.1, 151-152, 1998..[著者] ... Akira Otaka, Kengo Miyoshi, Midori Kaneko, Terrence Jr R. Burke, Peter P. Roller, Hirokazu Tamamura and Nobutaka Fujii : Development of New Efficient Deprotecting Methodologies for The Synthesis of Phosphoamino Acids-Containing Peptides, Peptides 1996, (巻), (号), 701-702, 1998..[著者] ... Atsushi Kosaki, Kazunori Yamada, Junko Suga, Akira Otaka and Hideshi Kuzuya : 14-3-3β Protein Associates with Insulin Receptor Substrate 1 and Decreases Insulin-stimulated Phosphatidylinositol 3-Kinase Activity in 3T3L1 Adipocytes, The Journal of Biological Chemistry, Vol.273, No.2, 940-944, 1998..[著者] ... Hirokazu Tamamura, Rieko Arakaki, Hanae Funakoshi, Makoto Imai, Akira Otaka, Toshiro Ibuka, Hideki Nakashima, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Effective lowly cytotoxic analogs of an HIV-cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II), Bioorganic & Medicinal Chemistry, Vol.6, No.2, 231-238, 1998..[著者] ... Hirokazu Tamamura, Michinori Waki, Makoto Imai, Akira Otaka, Toshiro Ibuka, Koji Waki, Kenji Miyamoto, Akiyoshi Matsumoto, Tsutomu Murakami, Hideki Nakashima, Naoki Yamamoto and Nobutaka Fujii : Downsizing of an HIV cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-Polyphemusin II), with the maintenance of anti-HIV activity and solution structure, Bioorganic & Medicinal Chemistry, Vol.6, No.4, 473-479, 1998..[著者] ... Hirokazu Tamamura, Makoto Imai, Tsunehito Ishihara, Masao Masuda, Hanae Funakoshi, Hiromi Oyake, Tsutomu Murakami, Rieko Arakaki, Hideki Nakashima, Akira Otaka, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Pharmacophore identification of a chemokine receptor (CXCR4) antagonist, T22 ([Tyr5,12, Lys7]-polyphemusin II), which specifically blocks T cell-line-tropic HIV-1 infection, Bioorganic & Medicinal Chemistry, Vol.6, No.7, 1033-1041, 1998..[著者] ... Motoyoshi Nomizu, Yuichiro Kuratomi, Katherine M. Malinda, Sang Yong Song, Kengo Miyoshi, Akira Otaka, Sharon K. Powell, Matthew P. Hoffman, Hynda K. Kleinman and Yoshihiko Yamada : Cell Binding Sequences in Mouse Laminin 1 Chain, The Journal of Biological Chemistry, Vol.273, No.49, 32491-32499, 1998..[著者] ... Hirokazu Tamamura, Younong Xu, Toshio Hattori, Xiaoyan Zhang, Rieko Arakaki, Kenji Kanbara, Akane Omagari, Akira Otaka, Toshiro Ibuka, Naoki Yamamoto, Hideki Nakashima and Nobutaka Fujii : A Low-Molecular-Weight Inhibitor against the Chemokine Receptor CXCR4: A Strong Anti-HIV Peptide T140, Biochemical and Biophysical Research Communications, Vol.253, No.3, 877-882, 1998..[著者] ... 大髙 章, 相本 三郎 : 構造生物学の方法論の新しい展開, --- リン酸化ペプチドの化学合成 ---, 蛋白質 核酸 酵素, Vol.44, (号), 302-309, 1999年(0月)..[著者] ... Akira Otaka, Etsuko Mitsuyama, Shinya Oishi, Kengo Miyoshi, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of Nonhydrolyzable Phosphothreonine Mimetic and Its Practical Application to Peptide Synthesis, Peptide 1998, (巻), (号), 264-265, 1999..[著者] ... H. Mariko, Hirokazu Tamamura, Akira Otaka, Toshiro Ibuka, Rieko Arakaki, Hideki Nakashima and Nobutaka Fujii : Ring-closing Metathesis Produced a CXCR4 Antagonist with Anti-HIV Activity, Peptide 1998, (巻), (号), 662-663, 1999..[著者] ... Hirokazu Tamamura, Tsunehito Ishihara, Hiromi Oyake, Akira Otaka and Nobutaka Fujii : Convenient One-pot Synthesis of Cystine-containing Peptides from Protected Peptidyl Resins and Its Application to the Synthesis of Bifunctional Anti-HIV Compounds, Peptide Science Present and Future, (巻), (号), 41-43, 1999..[著者] ... Hirokazu Tamamura, Masaki Yamashita, Hiroyuki Muramatsu, Toshiro Ibuka, Akira Otaka and Nobutaka Fujii : Stereoselctive Synthesis of Two Type (E)-Alkene Dipeptide Isosteres from a Single Substrate of β-Aziridinyl-α ,β-enoate, Peptide Science Present and Future, (巻), (号), 44-46, 1999..[著者] ... Hirokazu Tamamura, F Matsumoto, Kyoko Sakano, Akira Otaka, Tsutomu Murakami, Hideki Nakashima, Michinori Waki, Akiyoshi Matsumoro, Naoki Yamamoto and Nobutaka Fujii : An Anti-HIV Peptide T22 is Confirmed to Be a Selective CXCR4/Fusin Inhibitor by Comparative Inhibition Study of a Chemokine SDF-1,Synthesized by Regioselective Disulfide Bond Formation, Peptide Science Present and Future, (巻), (号), 398-402, 1999..[著者] ... Hirokazu Tamamura, Michinori Waki, Akira Otaka, Tsutomu Murakami, Hideki Nakashima, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : HIV-cell Fusin Inhibitor T22([Tyr5,12,Lys7]-polyphemusin II),and Its Related Compounds, Peptide Science Present and Future, (巻), (号), 424-426, 1999..[著者] ... Hirokazu Tamamura, Michinori Waki, Akira Otaka, Tsutomu Murakami, Hideki Nakashima, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Efficient Analog of An Anti-HIV Peptide,T22 ([Tyr5,12,Lys7]-polyphemusin II),Having Low Cytotoxicity, Peptide Science Present and Future, (巻), (号), 427-429, 1999..[著者] ... Akira Otaka, Y. Umeda, Hirokazu Tamamura, Toshiro Ibuka and Nobutaka Fujii : Synthesis of Protected 2,3-Epoxy Amines Utilizing Aza-Payne Rearrangement of Activated 2-Aziridinemethanols Under Basic Conditions, Peptide Science Present and Future, (巻), (号), 504-506, 1999..[著者] ... Kengo Miyoshi, Akira Otaka, Midori Kaneko, Hirokazu Tamamura and Nobutaka Fujii : Convenient Preparation of Phosphopeptide Fagments Using High TFMSA System and Its Application to Synthesis of Long Chain Phosphopeptides, Peptide Science Present and Future, (巻), (号), 507-509, 1999..[著者] ... Hirokazu Tamamura, Akane Omagari, Tsutomu Murakami, Rieko Arakaki, Younong Xu, Toshio Hattori, Michinori Waki, Akiyoshi Matsumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : HIV-cell Fusion Inhibitors:T22 and Its Downsized Analogs with High Activity, Peptide Science 1998, (巻), (号), 49-52, 1999..[著者] ... Akira Otaka, Etsuko Mitsuyama, Kengo Miyoshi and Nobutaka Fujii : Synthesis of Nonhydrolyzable Phosphthreonine Derivatives and Their Practical Application to Peptide Synthesis, Peptide Science 1998, (巻), (号), 137-140, 1999..[著者] ... M Hirohashi, Shinya Oishi, Tsutomu Murakami, Rieko Arakaki, Younong Xu, Toshio Hattori, Naoki Yamamoto, Takatomo Koshiba, Ryo Hosotani, Masayuki Imamura, T Mio, S Nagai, T Izumi, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Synthesis of a CC Chemokine vMIP-II,Encoded by Kaposi's Sarcoma-associated Herpesvirus and Its Biological Activity, Peptide Science 1998, (巻), (号), 285-288, 1999..[著者] ... Shunji Kanaoka, Seiji Yamasaki, Takashi Okino, Naoya Inoue, Yutaka Shimada, Midori Kaneko, Akira Otaka, Nobutaka Fujii and Masayuki Imamura : Induction of human leukocyte antigen (HLA)-A2-restricted and MAGE-3-gene-derived peptide-specific cytolytic T lymphocytes using cultured dendritic cells from an HLA-A2 esophageal cancer patient, Journal of Surgical Oncology, Vol.71, No.1, 16-21, 1999..[著者] ... Hirokazu Tamamura, Masaki Yamashita, Yutaka Nakajima, Kyoko Sakano, Akira Otaka, Hiroaki Ohno, Toshiro Ibuka and Nobutaka Fujii : Regiospecific ring-opening reactions of β-aziridinyl α,β-enoates with acids: application to the stereoselective synthesis of a couple of diastereoisomeric (E)-alkene dipeptide isosteres from a single β-aziridinyl α,β-enoate and to the convenient preparation of amino alcohols bearing α,β-unsaturated ester groups, Journal of the Chemical Society, Perkin Transactions 1, (巻), (号), 2983-2996, 1999..[著者] ... Yoshihiro Kuroda, Yoshitaka Maeda, Kazuhide Miyamoto, Kazufumi Tanaka, Kenji Kanaori, Akira Otaka, Nobutaka Fujii and Terumichi Nakagawa : 1H-NMR and Circular Dichroism Spectroscopic Studies on Changes in Secondary Structures of the Sodium Channel Inactivation Gate Peptides as Caused by the Pentapeptide KIFMK, Biophysical Journal, Vol.77, No.3, 1363-1373, 1999..[著者] ... Akira Otaka, Etsuko Mitsuyama, Hideaki Watanabe, Hirokazu Tamamura and Nobutaka Fujii : Development of new methodology for the synthesis of functionalized α-fluorophosphonates and its practical application to the preparation of phosphopeptide mimetics, Chemical Communications, (巻), (号), 1081-1082, 2000..[著者] ... 大髙 章 : 高付加価値ペプチド合成のための最終脱保護法の開発と細胞内情報伝達機構解明への展開研究, 薬学雑誌, Vol.120, (号), 54-67, 2000年(0月)..[著者] ... Motoyoshi Nomizu, Yuichiro Kuratomi, Akira Otaka, Hynda K. Kleinman, Yoshihiko Yamada and Norio Nishi : Identification of Biologically Active Peptides in Laminin-1, Peptide Science 1999, (巻), (号), 21-24, 2000..[著者] ... Nobutaka Fujii, M Hirohashi, Shinya Oishi, M Akaji, Akane Omagari, Akira Otaka and Toshiro Ibuka : Application of Ring Closing Olefin Metathesis to the Conformational Restriction of Biological Active Peptide, Peptide Science 1999, (巻), (号), 193-194, 2000..[著者] ... Akira Otaka, Y. Umeda, Shinya Oishi, Toshiro Ibuka and Nobutaka Fujii : New Strategy for the Synthesis of Aspartyl Protease Inhibitor Based on "Aza-Payne Rearrangement", Peptide Science 1999, (巻), (号), 195-196, 2000..[著者] ... Motoyoshi Nomizu, Yuichiro Kuratomi, M. Lourdes Ponce, Sang Yong Song, Kengo Miyoshi, Akira Otaka, Sharon K. Powell, Matthew P. Hoffman, Hynda K. Kleinman and Yoshihiko Yamada : Cell Adhesive Sequences in Mouse Laminin β1 Chain, Archives of Biochemistry and Biophysics, Vol.378, No.2, 311-320, 2000..[著者] ... Kengo Miyoshi, Akira Otaka, Midori Kaneko, Hirokazu Tamamura and Nobutaka Fujii : A New Practical Strategy for the Synthesis of Long-chain Phosphopeptide, Chemical & Pharmaceutical Bulletin, Vol.48, No.88, 1230-1233, 2000..[著者] ... Akira Otaka, Etsuko Mitsuyama, Takayoshi Kinoshita, Hirokazu Tamamura and Nobutaka Fujii : Stereoselective Synthesis of CF2-Substituted Phosphothreonine Mimetics and Their Incorporation into Peptides Using Newly Developed Deprotection Procedures, The Journal of Organic Chemistry, Vol.65, No.16, 4888-4899, 2000..[著者] ... Yoshihiro Kuroda, Kazuhide Miyamoto, M Matsumoto, Yishitaka Maeda, Kenji Kanaori, Akira Otaka, Nobutaka Fujii and Terumichi Nakagawa : Structural study of the sodium channel inactivation gate peptide including an isoleucine-phenylalanine-methionine motif and its analogous peptide (phenylalanine/glutamine) in trifluoroethanol solutions and SDS micelles, The Journal of Peptide Research, Vol.56, No.3, 172-184, 2000..[著者] ... Yoshihiro Kuroda, Kazuhide Miyamoto, Kazufumi Tanaka, Yoshitaka Maeda, J Ishikawa, R Hinata, Akira Otaka, Nobutaka Fujii and Terumichi Nakagawa : Interactions between Local Anesthetics and Na+ Channel Inactivation Gate Peptides in Phosphatidylserine Suspensions as Studied by 1H-NMR Spectroscopy, Chemical & Pharmaceutical Bulletin, Vol.48, No.9, 1293-1298, 2000..[著者] ... Yoshimi Sagawa, Yoshiyuki Yoshimura, Akira Otaka and Takashi Yamauchi : Ca2+-independent activity of Ca2+/calmodulin-dependent protein kinase II involved in stimulation of neurite outgrowth in neuroblastoma cells, Brain Research, Vol.881, No.2, 165-175, 2000..[著者] ... Koji Fujimoto, Ryo Hosotani, Yoshiharu Miyamoto, Ryuichiro Doi, Takatomo Koshiba, Akira Otaka, Nobutaka Fujii, Robert D. Beauchamp and Masayuki Imamura : Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16(INK4A) fusion peptide in pancreatic cancer cells, Cancer Letters, Vol.159, No.2, 151-158, 2000..[著者] ... Hirokazu Tamamura, Akane Omagari, Shinya Oishi, Taisei Kanamoto, Naoki Yamamoto, Stephen C. Peiper, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes, Bioorganic & Medicinal Chemistry Letters, Vol.10, No.23, 2633-2637, 2000..[著者] ... Shinya Oishi, Hirokazu Tamamura, Masaki Yamashita, Yoshihiko Odagaki, Nobuyuki Hamanaka, Akira Otaka and Nobutaka Fujii : Stereoselective synthesis of a set of two functionalized (E)-alkene dipeptide isosteres of L-amino acid-L-Glu and L-amino acid-D-Glu, Journal of the Chemical Society, Perkin Transactions 1, (巻), (号), 2445-2451, 2001..[著者] ... Akira Otaka, Hideaki Watanabe, Junko Watanabe, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of Fluoroalkene Dipeptide Isosteres Utilizing Organometallic Reagents, Peptides: The Wave of the Future, (巻), (号), 606-607, 2001..[著者] ... Akira Otaka, Etsuko Mitsuyama, Hideaki Watanabe, Hirokazu Tamamura, T Hayashi, K. Nakao and Nobutaka Fujii : Stereoselective Synthesis of CF2 or CHF-Substituted Phosphoamino Acids and Their Incorporation into Peptide, Peptide Science 2000, (巻), (号), 17-20, 2001..[著者] ... Akane Omagari, Hirokazu Tamamura, Shinya Oishi, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Development of Specific CXCR4 Inhibitors Based on an anti-HIV peptide, T140, and Their Structure-Activity Relationship Study, Peptide Science 2000, (巻), (号), 129-132, 2001..[著者] ... Shinya Oishi, Takae Kamano, Ayumu Niida, M. Kwaguchi, Ryo Hosotani, Masayuki Imamura, N. Yawata, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Efficient Synthesis of Cyclic RGD Pseudopeptide with (E)-Alkene Dipeptide Isosteres and Its Biological Activity, Peptide Science 2000, (巻), (号), 249-250, 2001..[著者] ... Akira Otaka, Hideaki Watanabe, Etsuko Mitsuyama, Akira Yukimasa, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of (Z)-fluoroalkene dipeptide isosteres utilizing organocopper-mediated reduction of γ,γ-difluoro-α,β-enoates, Tetrahedron Letters, Vol.42, No.2, 285-287, 2001..[著者] ... Hirokazu Tamamura, Makiko Sugioka, Yoshihiko Odagaki, Akane Omagari, Yukiko Kan, Shinya Oishi, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Nobuyuki Hamanaka, Akira Otaka and Nobutaka Fujii : Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity, Bioorganic & Medicinal Chemistry Letters, Vol.11, No.3, 359-362, 2001..[著者] ... Terrence R Burke-Jr, Jun-Zhu Yao, Bin Ye, Kengo Miyoshi, Akira Otaka, Li Wu and Zhong-Yin Zhang : Phospho-azatyrosine, a less effective protein-tyrosine phosphatase substrate than phosphotyrosine, Bioorganic & Medicinal Chemistry Letters, Vol.11, No.10, 1265-1268, 2001..[著者] ... Hirokazu Tamamura, Akane Omagari, Kenichi Hiramatsu, Kazuyo Gotoh, Taisei Kanamoto, Younong Xu, Eiichi Kodama, Masao Matsuoka, Toshio Hattori, Naoki Yamamoto, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140, Bioorganic & Medicinal Chemistry Letters, Vol.11, No.14, 1897-1902, 2001..[著者] ... Hirokazu Tamamura, Akane Omagari, Kenichi Hiramatsu, Taisei Kanamoto, Kazuyo Gotoh, Kenji Kanbara, Naoki Yamamoto, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Synthesis and evaluation of bifunctional anti-HIV agents based on specific CXCR4 antagonists-AZT conjugation, Bioorganic & Medicinal Chemistry, Vol.9, No.8, 2179-2187, 2001..[著者] ... Akira Otaka, Hideaki Watanabe, Akira Yukimasa, Shinya Oishi, Hirokazu Tamamura and Nobutaka Fujii : New access to α-substituted (Z)-fluoroalkene dipeptide isosteres utilizing organocopper reagents under `reduction oxidative alkylation (R-OA)' conditions, Tetrahedron Letters, Vol.42, No.32, 5443-5446, 2001..[著者] ... Toshiaki Hara, Yasuyuki Mitani, Kyoko Tanaka, Natsuko Uematsu, Asako Takakura, Tomoya Tachi, Hiroaki Kodama, Michio Kondo, Harumi Mori, Akira Otaka, Nobutaka Fujii and Katsumi Matsuzaki : Heterodimer Formation between the Antimicrobial Peptides Magainin 2 and PGLa in Lipid Bilayers: A Cross-Linking Study, Biochemistry, Vol.40, No.41, 12395-12399, 2001..[著者] ... Hirokazu Tamamura, Tadakazu Hori, Akira Otaka and Nobutaka Fujii : Efficient stereoselective synthesis of peptidomimetics containing hydroxyethylamine dipeptide isosteres utilizing the aza-Payne rearrangement and O, N-acyl transfer reactions, Journal of the Chemical Society, Perkin Transactions 1, Vol.5, 577-580, 2002..[著者] ... Shinya Oishi, Ayumu Niida, Takae Kamano, Yoshihisa Miwa, Tooru Taga, Yoshihiko Odagaki, Nobuyuki Hamanaka, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Regio- and stereoselective ring-opening of chiral 1,3-oxazolidin-2-one derivatives by organocopper reagents provides novel access to di-, tri- and tetra-substituted alkene dipeptide isosteres, Journal of the Chemical Society, Perkin Transactions 1, (巻), (号), 1786-1793, 2002..[著者] ... Shinya Oishi, Takae Kamano, Ayumu Niida, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Organocopper-mediated Stereoselective Synthesis of multi-Substituted Alkene Dipeptide Isosteres and Application to cyclic RGD Peptides, Peptide 2002, (巻), (号), 244-245, 2002..[著者] ... Akira Otaka, Miki Nakamura, Eiichi Kodama, Susumu Uchiyama, Hirokazu Tamamura, Yuji Kobayashi, Masao Matsuoka and Nobutaka Fujii : Artificial Remodeling of gp41-C34 Peptide Leads to Effective HIV Fusion Inhibitor with High anti-HIV Activity, Peptide 2002, (巻), (号), 838-839, 2002..[著者] ... Kenichi Hiramatsu, Hirokazu Tamamura, Akane Omagari, Hideki Nakashima, Younong Xu, Masao Matsuoka, Akira Otaka and Nobutaka Fujii : Synthesis of Novel Anti-HIV Peptides Based on a CXCR4 Antagonist, T140, and Their SAR Study, Peptide Science 2001, (巻), (号), 175-178, 2002..[著者] ... Ayumu Niida, Shinya Oishi, Takae Kamano, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Synthesis of ψ[(E)-CMe=CMe]- and ψ[(E)-CMe=CH]-type Alkene Dipeptide Isosteres from a Chiral Amino Acide, Peptide Science 2001, (巻), (号), 237-240, 2002..[著者] ... Yoshihito Taniguchi, Helena Karlström, Johan Lundkvist, Tomohiko Mizutani, Akira Otaka, Monica Vestling, Alan Bernstein, Dorit Donoviel, Urban Lendahl and Tasuku Honjo : Notch receptor cleavage depends on but is not directly executed by presenilins, Proceedings of the National Academy of Sciences of the United States of America, Vol.99, No.6, 4014-4019, 2002..[著者] ... Junko Watanabe, Akira Otaka, Hideaki Watanabe, Akira Yukimasa, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of Fluoroalkene Dipeptide Isosteres Utilizing Organocopper or SmI2 Reagents, Peptide Science 2001, Vol.2001, No.0, 29-32, 2002..[著者] ... Miki Nakamura, Akira Otaka, Eiichi Kodama, Masao Matsuoka, Susumu Uchiyama, Syota Nakamura, Yuji Kobayashi, Hirokazu Tamamura and Nobutaka Fujii : Design and Synthesis of Highly Active Anti-HIV Peptide Based on gp41-C34 Peptide, Peptide Science 2001, Vol.2001, No.0, 73-76, 2002..[著者] ... Shinya Oishi, Takae Kamano, Ayumu Niida, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type Dipeptide Isosteres and Their Application to a Cyclic RGD Peptide, Peptide Science 2001, Vol.2001, No.0, 241-244, 2002..[著者] ... K. Takeshima, A. Chikushi, S Kobayashi, L. Kyung-Kwon, S Yonehara, Akira Otaka, Nobutaka Fujii and K Matsuzaki : Translocation of Basic Peptides through Human Cell Membranes, Peptide Science 2001, Vol.2001, No.0, 321-324, 2002..[著者] ... Hirokazu Tamamura, Kenichi Hiramatsu, Kazuhide Miyamoto, Akane Omagari, Shinya Oishi, Hideki Nakashima, Naoki Yamamoto, Yoshihiro Kuroda, Terumichi Nakagawa, Akira Otaka and Nobutaka Fujii : Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: The insertion of an (E)-alkene dipeptide isostere into the βII' -turn moiety, Bioorganic & Medicinal Chemistry Letters, Vol.12, No.6, 923-928, 2002..[著者] ... Ryo Hosotani, Yoshiharu Miyamoto, Koji Fujimoto, Ryuichiro Doi, Akira Otaka, Nobutaka Fujii and Masayuki Imamura : Trojan p16 Peptide Suppresses Pancreatic Cancer Growth and Prolongs Survival in Mice, Clinical Cancer Research, Vol.8, No.4, 1271-1276, 2002..[著者] ... Shinya Oishi, Ayumu Niida, Takae Kamano, Yoshihiko Odagaki, Hirokazu Tamamura, Akira Otaka, Nobuyuki Hamanaka and Nobutaka Fujii : Diastereoselective synthesis of psi[(E)-CMe=CH]- and psi[(E)-CMe=CMe]- type dipeptide isosteres based on organocopper-mediated anti-S(N)2' reaction, Organic Letters, Vol.4, No.7, 1055-1058, 2002..[著者] ... Shinya Oishi, Takae Kamano, Ayumu Niida, Yoshihiko Odagaki, Hirokazu Tamamura, Akira Otaka, Nobuyuki Hamanaka and Nobutaka Fujii : Diastereoselective synthesis of psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type dipeptide isosteres by organocopper-mediated anti-S(N)2' reaction, Organic Letters, Vol.4, No.7, 1051-1054, 2002..[著者] ... Hirokazu Tamamura, Akane Omagari, Kenichi Hiramatsu, Shinya Oishi, Hiromu Habashita, Taisei Kanamoto, Kazuyo Gotoh, Naoki Yamamoto, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Certification of the Critical Importance of L-3-(2-Naphthyl)alanine at Position 3 of a Specific CXCR4 Inhibitor, T140, Leads to an Exploratory Performance of Its Downsizing Study, Bioorganic & Medicinal Chemistry, Vol.10, No.5, 1417-1426, 2002..[著者] ... Masayoshi Makino, Ikuko Okazaki, Shingo Kasai, Norio Nishi, Maria Bougaeva, Benjamin S. Weeks, Akira Otaka, Peter K. Nielsen, Yoshihiko Yamada and Motoyoshi Nomizu : Identification of Cell Binding Sites in the Laminin α5-Chain G Domain, Experimental Cell Research, Vol.277, No.1, 95-106, 2002..[著者] ... Akira Otaka, Miki Nakamura, Daisuke Nameki, Eiichi Kodama, Susumu Uchiyama, Syota Nakamura, Hiroaki Nakano, Hirokazu Tamamura, Yuji Kobayashi, Masao Matsuoka and Nobutaka Fujii : Remodeling of gp41-C34 Peptide Leads to Highly Effective Inhibitors of the Fusion of HIV-1 with Target Cells, Angewandte Chemie International Edition, Vol.41, No.16, 2937-2940, 2002..[著者] ... Akira Otaka, Fumihiko Katagiri, Takayoshi Kinoshita, Yoshihiko Odagaki, Shinya Oishi, Hirokazu Tamamura, Nobuyuki Hamanaka and Nobutaka Fujii : Regio- and Stereoselective Synthesis of (E)-Alkene trans-Xaa-Pro Dipeptide Mimetics Utilizing Organocopper-Mediated Anti-SN2' Reactions, The Journal of Organic Chemistry, Vol.67, No.17, 6152-6161, 2002..[著者] ... Shinya Oishi, Takae Kamano, Ayumu Niida, Yoshihiko Odagaki, Nobuyuki Hamanaka, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Diastereoselective Synthesis of New Ψ [(E)-CH=CMe]- and Ψ [(Z)-CH=CMe]-type Alkene Dipeptide Isosteres by Organocopper Reagents and Application to Conformationally Restricted Cyclic RGD Peptidomimetics, The Journal of Organic Chemistry, Vol.67, No.17, 6162-6173, 2002..[著者] ... K Nemoto, Hirokazu Tamamura, S Mizokami, Shinya Oishi, Akira Otaka and Nobutaka Fujii : Acid-catalyzed Ring-opening Reactions of β-Aziridinyl-α,β-enoates and Their Application, Peptide Science 2002, (巻), (号), 139-142, 2003..[著者] ... Hirokazu Tamamura, Terukazu Kato, Tadakazu Hori, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of Peptidomimetics with Hydroxyethylamine Diepetide Isosteres Utilizing Aza-Payne Rearrangement and O,N-Acyl Transfer Reactions, Peptide Science 2002, (巻), (号), 143-146, 2003..[著者] ... Akira Otaka, Miki Nakamura, Eiichi Kodama, Syota Nakamura, Hiroaki Nakano, Susumu Uchiyama, Hirokazu Tamamura, Masao Matsuoka, Yuji Kobayashi and Nobutaka Fujii : Development of Fusion-inhibiting Anti-HIV-1 Peptides Based on the Structure of Molecular Complex Involved in HIV-1-cell Fusion, Peptide Science 2002, Vol.2002, No.0, 65-68, 2003..[著者] ... Kenichi Hiramatsu, Hirokazu Tamamura, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Synthesis of CXCR4 Antagonists,T140 Derivatives with Improved Biostability, and Their SAR Study, Peptide Science 2002, Vol.2002, No.0, 213-216, 2003..[著者] ... Akira Otaka, Yoshikazu Sasaki, Fumihiko Katagiri, Shinya Oishi, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of(E)-Alkene trans-Xaa-Pro Mimetics Using Organocopper Reagents, Peptide Science 2002, Vol.2002, No.0, 357-360, 2003..[著者] ... Hirokazu Tamamura, Yasuhiro Koh, Satoshi Ueda, Yoshikazu Sasaki, Tomonori Yamasaki, Manabu Aoki, Kenji Maeda, Yoriko Watai, Hisashi Arikuni, Akira Otaka, Hiroaki Mitsuya and Nobutaka Fujii : Reduction of Peptide Character of HIV Protease Inhibitors That Exhibit Nanomolar Potency against Multidrug Resistant HIV-1 Strains, Journal of Medicinal Chemistry, Vol.46, No.9, 1764-1768, 2003..[著者] ... Hirokazu Tamamura, Terukazu Kato, Akira Otaka and Nobutaka Fujii : Synthesis of potent beta-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies, Organic & Biomolecular Chemistry, Vol.1, No.14, 2468-2473, 2003..[著者] ... Nobutaka Fujii, Shinya Oishi, Kenichi Hiramatsu, Takanobu Araki, Satoshi Ueda, Hirokazu Tamamura, Akira Otaka, Shuichi Kusano, Shigemi Terakubo, Hideki Nakashima, James A. Broach, John O. Trent, Zi-xuan Wang and Stephen C. Peiper : Molecular-Size Reduction of a Potent CXCR4-Chemokine Antagonist Using Orthogonal Combination of Conformation- and Sequence-Based Libraries, Angewandte Chemie International Edition, Vol.42, No.28, 3251-3253, 2003..[著者] ... Akira Otaka, Akira Yukimasa, Junko Watanabe, Yoshikazu Sasaki, Sinya Oishi, Hirokazu Tamamura and Nobutaka Fujii : Application of samarium diiodide (SmI2)-induced reduction of γ-acetoxy-α,β-enoates with α-specific kinetic electrophilic trapping for the synthesis of amino acid derivatives, Chemical Communications, (巻), No.15, 1834-1835, 2003..[著者] ... Hirokazu Tamamura, Akira Hori, Naoyuki Kanzaki, Kenichi Hiramatsu, Makiko Mizumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Fujii Nobutaka : T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer, FEBS Letters, Vol.550, No.3, 79-83, 2003..[著者] ... Hirokazu Tamamura, Kenichi Hiramatsu, Shuichi Kusano, Shigemi Terakubo, Naoki Yamamoto, John O. Trent, Zixuan Wang, Stephen C. Peiper, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives, Organic & Biomolecular Chemistry, Vol.1, No.21, 3656-3662, 2003..[著者] ... Hirokazu Tamamura, Kenichi Hiramatsu, Makiko Mizumoto, Satoshi Ueda, Shuichi Kusano, Shigemi Terakubo, Miki Akamatsu, Naoki Yamamoto, John O. Trent, Zixuan Wang, Stephen C. Peiper, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists, Organic & Biomolecular Chemistry, Vol.1, No.21, 3663-3669, 2003..[著者] ... Akira Otaka, Etsuko Mitsuyama, Junko Watanabe, Hideaki Watanabe and Nobutaka Fujii : Synthesis of fluorine-containing bioisosteres corresponding to phosphoamino acids and dipeptide units, Biopolymers, Vol.76, No.2, 140-149, (month)2004..[著者] ... Satoshi Ueda, Kenji Tomita, Akira Otaka, Hirokazu Tamamura, Yoshiaki Yano, Katsumi Matsuzaki and Nobutaka Fujii : Synthesic Studies on 7TM-GPCR (I):Lipid Bilayer Assisted Membrane Peptide Ligation, Peptide Science 2003, Vol.40, (号), 53-56, 2004..[著者] ... Takanobu Araki, Satoshi Ueda, Kenichi Hiramatsu, Shinya Oishi, Hirokazu Tamamura, Akira Otaka, Nobutaka Fujii, Shuichi Kusano, Shigemi Terakubo, Hideki Nakashima, Zixuan Wang and Stephen C. Peiper : A New Strategy for Molecular-size Reduction Bioactive Peptide, Using Two Orthogonal Libraries of Cyclic Peptided, Peptide Science 2003, (巻), (号), 207-210, 2004..[著者] ... Hirokasu Tamamura, Akira Hori, Naoyuki Kanzaki, Kenichi Hiramatsu, Makiko Mizumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : CXCR4 Antagonists Identified as Anti-Cancer Metastatic Agents, Peptide Science 2003, Vol.2003, No.0, 65-68, 2004..[著者] ... Terukazu Kato, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Development of Potent β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere, Peptide Science 2003, Vol.2003, No.0, 231-234, 2004..[著者] ... S Mizokami, Hirokazu Tamamura, Kenichi Hiramatsu, Makiko Mizumoto, Miki Akamatsu, Hideki Nakashima, Zixuan Wang, Stephen C. Peiper, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : New Leads of Low Molecular Weight CXCR4 Antagonists Based on Enhancement of the T140-based Pharmacophores, Peptide Science 2003, Vol.2003, No.0, 285-288, 2004..[著者] ... Akira Otaka, Junko Watanabe, Akira Yukimasa, Yoshikazu Sasaki, Hideaki Watanabe, Takayoshi Kinoshita, Shinya Oishi, Hirokazu Tamamura and Nobutaka Fujii : SmI2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized (Z)-Fluoroalkene-Type Dipeptide Isosteres, The Journal of Organic Chemistry, Vol.69, No.5, 1634-1645, 2004..[著者] ... Hirokazu Tamamura, Makiko Mizumoto, Kenichi Hiramatsu, Shuichi Kusano, Shigemi Terakubo, Naoki Yamamoto, John O. Trent, Zixuan Wang, Stephen C. Peiper, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides, Organic & Biomolecular Chemistry, Vol.2, No.8, 1255-1257, 2004..[著者] ... Norio Yamamoto, Rongge Yang, Yoshiyuki Yoshinaka, Shinji Amari, Tatsuya Nakano, Jindrich Cinatl, Holger Rabenau, Hans Wilhelm Doerr, Gerhard Hunsmann, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii and Naoki Yamamoto : HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus, Biochemical and Biophysical Research Communications, Vol.318, No.3, 719-725, 2004..[著者] ... Akira Otaka, Satoshi Ueda, Kenji Tomita, Yoshiaki Yano, Hirokazu Tamamura, Katsumi Matsuzaki and Nobutaka Fujii : Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation, Chemical Communications, (巻), No.15, 1722-1723, 2004..[著者] ... Taro Toyoda, Tatsuya Hayashi, Licht Miyamoto, Shin Yonemitsu, Masako Nakano, Satsuki Tanaka, Ken Ebihara, Hiroaki Masuzaki, Kiminori Hosoda, Gen Inoue, Akira Otaka, Kenji Sato, Tohru Fushiki and Kazuwa Nakao : Possible involvement of the α1 isoform of 5'AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle, American Journal of Physiology, Endocrinology and Metabolism, Vol.287, No.1, E166-173, 2004..[著者] ... Hirokazu Tamamura, Miho Fujisawa, Kenichi Hiramatsu, Makiko Mizumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent, FEBS Letters, Vol.569, No.1-3, 99-104, 2004..[著者] ... 大髙 章, 藤井 信孝, 山本 直樹 : SARS治療薬の展望, 現代医療, Vol.36, No.11, 64-51, 2004年11月..[著者] ... 西川 裕輝, 藤井 信孝, 大髙 章 : 抗SARS-CoV活性ペプチドの創製研究, Med. Chem. News, Vol.15, (号), 18-23, 2005年(0月)..[著者] ... Ayumu Niida, Makiko Mizumoto, Yoshikazu Sasaki, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of Diketopiperazine Mimmetics as Promising Scaffolds for Drug Discovery Utilizing Organocopper-Mediated anti-SN2' Reaction, Peptide Science 2004, (巻), (号), 169-172, 2005..[著者] ... Daisuke Nameki, Eiichi Kodama, Mieko Ikeuchi, Naoto Mabuchi, Akira Otaka, Hirokazu Tamamura, Mutsuhito Ohno, Nobutaka Fujii and Masao Matsuoka : Mutations Conferring Resistance to Human Immunodeficiency Virus Type 1 Fusion Inhibitors Are Restricted by gp41 and Rev-Responsive Element Functions, Journal of Virology, Vol.79, No.2, 764-770, 2005..[著者] ... Hirokazu Tamamura, Kenichi Hiramatsu, Satoshi Ueda, Zixuan Wang, Shuichi Kusano, Shigemi Terakubo, John O. Trent, Stephen C. Peiper, Naoki Yamamoto, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-Type (E)-Alkene Dipeptide Isosteres and Its Application to the Synthesis and Biological Evaluation of Pseudopeptide Analogues of the CXCR4 Antagonist FC131, Journal of Medicinal Chemistry, Vol.48, No.2, 380-391, 2005..[著者] ... Hirokazu Tamamura, Kenichi Hiramatsu, Satoshi Ueda, Takanobu Araki, M Takenaga, R Igarashi, Akira Hori, Naoyuki Kanzaki, Miho Fujisawa, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases Including AIDS, Cancer and Rheumatoid Arthritis, Peptide Science 2004, Vol.2004, (号), 121-122, 2005..[著者] ... Hirokazu Tamamura, Takanobu Araki, Ai Esaka, Satoshi Ueda, Shinya Oishi, Zixuan Wang, Stephen C. Peiper, Akira Otaka and Nobutaka Fujii : Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetrapeptide-scaffolds, Peptide Science 2004, Vol.2004, (号), 509-510, 2005..[著者] ... Terukazu Kato, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere and their Structure-activity Relationship Studies, Peptide Science 2004, Vol.2004, (号), 515-516, 2005..[著者] ... Satoshi Ueda, Akira Otaka, Hirokazu Tamamura and Nobutaka Fujii : 4-(Dimethylamino)phenacyl Group: New Photoremovable Protecting Group for Amines and Carboxylic Acids, Peptide Science 2004, Vol.2004, (号), 599-602, 2005..[著者] ... Hirokazu Tamamura, Takanobu Araki, Satoshi Ueda, Zixuan Wang, Shinya Oishi, Ai Esaka, John O. Trent, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka and Nobutaka Fujii : Identification of Novel Low Molecular Weight CXCR4 Antagonists by Structural Tuning of Cyclic Tetrapeptide Scaffolds, Journal of Medicinal Chemistry, Vol.48, No.9, 3280-3289, 2005..[著者] ... Ayumu Niida, Shinya Oishi, Yoshikazu Sasaki, Makiko Mizumoto, Hirokazu Tamamura, Nobutaka Fujii and Akira Otaka : Facile access to (Z)-alkene-containing diketopiperazine mimetics utilizing organocopper-mediated anti-SN2 reactions, Tetrahedron Letters, Vol.46, No.24, 4183-4186, 2005..[著者] ... Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Development of Anti-HIV Agents Targeting Dynamic Supramolecular Mechanism: Entry and Fusion Inhibitors Based on CXCR4/CCR5 Antagonists and gp41-C34-Remodeling Peptides, Current HIV Research, Vol.3, No.4, 289-301, 2005..[著者] ... Satoshi Ueda, Mizuno Fujita, Hirokazu Tamamura, Nobutaka Fujii and Akira Otaka : Photolabile Protection for One-Pot Sequential Native Chemical Ligation, ChemBioChem, Vol.6, No.11, 1983-1986, 2005..[著者] ... 藤井 信孝, 大髙 章, 玉村 啓和 : ケミカルプロテオミックス先導型創薬基盤の革新, 細胞工学, Vol.15, No.11, 1181-1186, 2005年11月..[著者] ... Hirokazu Tamamura, Ai Esaka, Teppei Ogawa, Takanobu Araki, Satoshi Ueda, Zixuan Wang, John O. Trent, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka and Nobutaka Fuji : Structure activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds, Organic & Biomolecular Chemistry, Vol.3, No.24, 4392-4394, 2005..[著者] ... Ayumu Niida, Zixuan Wang, Kenji Tomita, Shinya Oishi, Hirokazu Tamamura, Akira Otaka, Jean-Marc Navenot, James R. Broach, Stephen C. Peiper and Nobutaka Fujii : Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity, Bioorganic & Medicinal Chemistry Letters, Vol.16, No.1, 134-137, 2006..[著者] ... Shinya Ohishi, Kazuhide Miyamoto, Ayumu Niida, Mikiko Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka, Yoshihiro Kuroda, Akira Asai and Fujii Nobutaka : Application of Tri- and Tetrasubstituted Alkene Dipeptide Mimetics to Conformational Studies of Cyclic RGD Peptides., Tetrahedron, Vol.62, No.7, 1416-1424, 2006..[著者] ... Ayumu Niida, Kenji Tomita, Makiko Mizumoto, Hiroaki Tanigaki, Tomohiro Terada, Shinya Oishi, Akira Otaka, Ken-ichi Inui and Nobutaka Fujii : Unequivocal Synthesis of (Z)-Alkene and (E)-Fluoroalkene Dipeptide Isosters to Probe Structural Requirements of Peptide Transporter PEPT1., Organic Letters, Vol.8, No.4, 613-616, 2006..[著者] ... M Nakano, T Hamada, T Hayashi, S Yonemitsu, L Miyamoto, T Toyoda, S Tanaka, H Masuzaki, K Ebihara, Y Ogawa, K Hosoda, G Inoue, Y Yoshimasa, Akira Otaka, T Fushiki and K Nakao : a2 Isoform-specific activation of 5 adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle, Metabolism: Clinical and Experimental, Vol.55, No.3, 300-308, 2006..[著者] ... Akira Otaka, Yusuke Ohta, Akira Shigenaga and Nobutaka Fujii : Preparation of peptide thioester utilizing S-protected oxazolidinone derived from systeine, The 11th Korea-Japan Joint Symposium On Drug Design and Development, (巻), (号), (頁), Cheju, May 2006..[著者] ... Ayumu Niida, Hiroaki Tanigaki, Eriko Inokuchi, Yoshikazu Sasaki, Shinya Oishi, Hiroaki Ohno, Hirokazu Tamamura, Zixuan Wang, C Stephene Peiper, Kazuo Kitaura, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of 3,6-Disubstituted-3,6-dihydropyridin-2-ones as Potential Diketopiperazine Mimetics Using Organocopper-Mediated anti-SN2' Reactions and Their Use in the Preparation of Low-Molecule CXCR4 Antagonists., The Journal of Organic Chemistry, Vol.71, No.10, 3942-3951, 2006..[著者] ... Ayumu Niida, Makiko Mizumoto, Tetsuo Narumi, Eriko Inokuchi, Shinya Oishi, Hiroaki Ohono, Akira Otaka, Kazuo Kitaura and Fujii Nobutaka : Synthesis of (Z)-Alkene and (E)-Fluoroalkene-Containing Diketopiperazine Mimetics Utilizing Oraganocopper-Mediated Reduction-Alkylation and Diastereoselectivity Examination Using DFT Calculations., The Journal of Organic Chemistry, Vol.71, No.11, 4118-4129, 2006..[著者] ... Akira Shigenaga, Saori Shintaku and Akira Otaka : Design, Synthesis and Photo-processing Reaction of Peptides Possessing the External Stimulus-responsive Amino Acid, 29th European Peptide Symposium, (巻), (号), (頁), Gdansk, Sep. 2006..[著者] ... Tesuo Narumi, Ayumu Niida, Kenji Tomita, Shinya Oishi, Akira Otaka, Hiroaki Ohono and Nobutaka Fujii : A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres., Chemical Communications, (巻), No.45, 4720-4722, 2006..[著者] ... 大髙 章 : 新しい薬をどう創るか, --- 創薬研究の最前線 ---, 株式会社 講談社, 東京, 2007年4月..[著者] ... 重永 章, 大髙 章 : Split and Pool法を用いたOne-bead, One-peptideライブラリーの構築とハイスループットスクリーニングへの展開, 蛋白質 核酸 酵素, Vol.52, No.13 Suppl, 1792-1793, 2007年10月..[著者] ... Akira Shigenaga, Daisuke Tsuji, Nishioka Naomi, Tsuda Shugo, Kouji Itou and Akira Otaka : Development of stimulus-responsive amino acid with peptide bond-cleavage ability and its application to a nucleocytoplasmic shuttle peptide, 第44回ペプチド討論会, (巻), (号), (頁), Nov. 2007..[著者] ... Ujike Makoto, Nishikawa Hiroki, Akira Otaka, Yamamoto Naoki, Yamamoto Norio, Matsuoka Masao, Kodama Eiichi, Fujii Nobutaka and Taguchi Fumihiro : Heptad Repeat-Derived Peptides Block Protease-Mediated Direct Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus but Not Entry via the Endosomal Pathway, Journal of Virology, Vol.82, No.1, 588-592, 2008..[著者] ... Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Shugo Tsuda, Kouji Itou and Akira Otaka : Development of stimulus-responsive amino acid with peptide bond-cleavage ability and its application to a nucleocytoplasmic shuttle peptide, Peptide Science 2007, Vol.2007, (号), 97-98, 2008..[著者] ... 重永 章, 西岡 直美, 山本 純, 大髙 章 : 任意の刺激応答型ペプチド結合切断デバイスの開発, 日本ケミカルバイオロジー研究会第3回年会, (巻), (号), (頁), 2008年5月..[著者] ... 辻 大輔, 難波 建多郎, 浦上 裕行, 重永 章, 大髙 章, 柏田 良樹, 高石 喜久, 伊藤 孝司 : 未分化細胞に対する神経分化誘導作用を持つ化合物の探索と構造活性相関, BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会), (巻), (号), (頁), 2010年12月..[著者] ... 辻 大輔, 難波 建多郎, 浦上 裕行, 辻 耕平, 重永 章, 大髙 章, 柏田 良樹, 高石 喜久, 伊藤 孝司 : ヒトiPS細胞に対する神経分化誘導能を持つ新規化合物の探索, 日本薬学会 第131年会, (巻), (号), (頁), 2011年3月..[著者] ... Akira Otaka, Kohei Sato, Hao Ding and Akira Shigenaga : N-Sulfanylethylanilide peptide for peptide engineering, The Sixth Peptide Engineering Meeting, (巻), (号), (頁), Atlanta, Oct. 2012..[著者] ... Emi Adachi, Asako Kosaka, Kohei Tsuji, Chiharu Mizuguchi, Hiroyuki Kawashima, Akira Shigenaga, Kohjiro Nagao, Kenichi Akaji, Akira Otaka and Hiroyuki Saito : The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils., FEBS Letters, Vol.588, No.3, 389-394, 2013..[著者] ... 足立 愛美, 辻 耕平, 川島 浩之, 重永 章, 長尾 耕治郎, 赤路 健一, 大髙 章, 斎藤 博幸 : フラグメントペプチドを用いたアポA-Iアミロイド線維形成領域の同定, 日本薬学会第134年会, 2014年3月..[著者] ... 假屋園 大和, 新村 航, 辻 耕平, 重永 章, 大髙 章, 斎藤 博幸 : DESIGN OF NANODISC SCAFFOLD PEPTIDE (NSP), 第51回ペプチド討論会, 2014年10月..[著者] ... 山岡 朋美, 宮本 理人, 川崎 彩, 山根 萌, 高橋 梨恵, 石澤 啓介, 宮島 凛, 重永 章, 大髙 章, 土屋 浩一郎 : Leptinによる骨格筋培養細胞での代謝制御作用におけるSIRT1の役割, 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, (巻), (号), (頁), 2014年11月..[著者] ... Yuki Haraya, Kento Tanaka, Kohei Tsuji, Yasuo Asami, Hironori Izawa, Akira Shigenaga, Akira Otaka, Hiroyuki Saito and Kohsaku Kawakami : Molecular Complex Composed of -Cyclodextrin-Grafted Chitosan and pH-Sensitive Amphipathic Peptide for Enhancing Cellular Cholesterol Efflux under Acidic pH, Bioconjugate Chemistry, Vol.26, No.3, 572-581, 2015..[著者] ... 三河 志穂, 水口 智晴, 辻 耕平, 馬場 照彦, 重永 章, 大髙 章, 斎藤 博幸 : アルギニン変異apoA-Iフラグメントのアミロイド線維形成性, 日本薬学会第135年会, 2015年3月..[著者] ... 武知 佑樹, 田中 健斗, 辻 耕平, 麻見 安雄, 井澤 浩則, 重永 章, 大髙 章, 川上 亘作, 斎藤 博幸 : シクロデキストリン架橋型キトサン-pH応答性ペプチド複合体による細胞コレステロール排出促進作用, 日本膜学会第37年会, 2015年5月..[著者] ... 三河 志穂, 水口 智晴, 辻 耕平, 重永 章, 島内 寿徳, 大髙 章, 斎藤 博幸 : アポA-Iアミロイド線維形成に与える脂質膜とヘパリンの影響, 日本膜学会第37年会, 2015年5月..[著者] ... Licht Miyamoto, Haruna Aihara, Wenting Xu, Meina Jin, Yosuke Tomida, Tomomi Yamaoka, Naonobu Tanaka, Yasumasa Ikeda, Akira Shigenaga, Akira Otaka, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya : Limonene-derivative Ameliorates Lipid Profiles by Upregulation of Sirt1 Activity and Expression in Cultured Cells and High Fat Diet-Fed Mice, American diabetes association, Boston, June 2015..[著者] ... Koji Takagi, Hayato Fukuda, Satoshi Syuto, Akira Otaka and Mitsuhiro Arisawa : Safe removal of the allyl protecting groups of allyl esters using a recyclable, low-leaching and ligand-free palladium nanoparticle Catalyst, Advanced Synthesis & Catalysis, Vol.357, No.9, 2119-2124, 2015..[著者] ... Chiharu Mizuguchi, Fuka Ogata, Shiho Mikawa, Kohei Tsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito : Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes, The Journal of Biological Chemistry, Vol.290, No.34, 20947-20959, 2015..[著者] ... 宮本 理人, 粟飯原 遥奈, Wenting Xu, Meina Jin, 冨田 洋介, 山岡 朋美, 田中 直伸, 池田 康将, 重永 章, 大髙 章, 玉置 俊晃, 柏田 良樹, 土屋 浩一郎 : リモネン誘導体によるsirt1活性化を介した脂質低下作用, 日本肥満学会，アジアオセアニア糖尿病学会, 名古屋, 2015年10月..[著者] ... 佐藤 智恵美, 山本 香織, 阿部 真治, 岡田 直人, 土屋 浩一郎, 東 満美, 大髙 章 : 病院・薬局実務実習における実習生の主体性育成に向けての取組み:課題発見型レポートの効果の検証, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2015年11月..[著者] ... 岡田 直人, 阿部 真治, 佐藤 智恵美, 東 満美, 川添 和義, 大髙 章, 石澤 啓介 : 徳島大学病院における模擬体験型学習を用いた実務実習の評価, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2015年11月..[著者] ... 松岡 恒輝, 佐藤 陽一, 大髙 章, 山内 あい子 : 薬物の胎児毒性に関する機械学習による予測と化学構造特性の解析, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, 2015年11月..[著者] ... 阿部 真治, 佐藤 智恵美, 山本 香織, 東 満美, 大髙 章 : 薬学体験実習における屋根瓦方式導入の有用性, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会 (高知), 2015年11月..[著者] ... Hirokazu Kariyazono, Ryo Nadai, Rin Miyajima, Yuki Haraya, Teruhiko Baba, Akira Shigenaga, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito : Formation of stable nanodiscs by bihelical apolipoprotein A-I mimetic peptide, Journal of Peptide Science, Vol.22, No.2, 116-122, 2016..[著者] ... Kitakaze Keisuke, Mizutani Yasumichi, Sugiyama Eiji, Tasaki Chikako, Daisuke Tsuji, Nobuo Maita, Hirokawa Takatsugu, Asanuma Daisuke, Kamiya Mako, Sato Kohei, Setou Mitsutoshi, Urano Yasuteru, Togawa Tadayasu, Akira Otaka, Sakuraba Hitoshi and Kouji Itou : Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model, The Journal of Clinical Investigation, Vol.126, No.5, 1691-1703, 2016..[著者] ... Yuki Haraya, Ryo Nadai, Hitoshi Kimura, Kazuchika Nishitsuji, Kenji Uchimura, Kumiko Sakai-Kato, Kohsaku Kawakami, Akira Shigenaga, Toru Kawakami, Akira Otaka, Hironobu Hojo, Naomi Sakashita and Hiroyuki Saito : Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides, Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.1858, No.6, 1339-1349, 2016..[著者] ... 川原 遥華, 奥平 桂一郎, 辻 耕平, 津田 雄介, 森本 恭平, 木村 仁, 假屋園 大和, 大村 理紗, 市野 晨人, 杉原 涼, 西辻 和親, 重永 章, 坂下 直実, 大髙 章, 斎藤 博幸 : 光応答性アボ A-I 模倣ペプチドの開発研究, 日本薬学会第136年会, 2016年3月..[著者] ... 灘井 亮, 武知 佑樹, 西辻 和親, 内村 健治, 加藤 くみ子, 重永 章, 川上 徹, 大髙 章, 北條 裕信, 坂下 直実, 斎藤 博幸 : アルギニンペプチドの細胞膜透過はグリコサミノグリカン糖鎖へのエンタルピー依存的結合によって促進される, 日本膜学会第38年会, (巻), (号), (頁), 2016年5月..[著者] ... Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Kohei Tsuji, Akira Shigenaga, Akira Otaka and Takahiko Hara : A CXC type chemokine CXCL14 directly binds to CpG-C DNA to activate Toll-like receptor 9 signaling, Nucleic Acid Sensing Pathways: Innate Immunity, Immunobiology and Therapeutics (E2), (巻), (号), (頁), Dresden, May 2016..[著者] ... 川添 和義, 阿部 真治, 清水 太郎, 石田 竜弘, 大髙 章 : 徳島大学発「インタラクティブYAKUGAKUJIN」の育成―新しい視点に立脚した教育の開発と実践―, 第1回日本薬学教育学大会, 2016年8月..[著者] ... Shiho Mikawa, Chiharu Mizuguchi, Kazuchika Nishitsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Naomi Sakashita, Akira Otaka, Kenichi Akaji and Hiroyuki Saito : Heparin promotes fibril formation of the N-terminal fragment of amyloidogenic aplipoprotein A-I, FEBS Letters, Vol.590, 3492-3500, 2016..[著者] ... 佐藤 智恵美, 阿部 真治, 岡田 直人, 石田 竜弘, 土屋 浩一郎, 大髙 章, 川添 和義 : 地域薬局における災害対策の現状と課題, 第55回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2016年11月..[著者] ... Koichiro Tsuchiya, Aihara Haruna, Xu Wenting, Jin Meina, Tomida Yosuke, Yamaoka Tomomi, Naonobu Tanaka, Yasumasa Ikeda, Akira Shigenaga, Akira Otaka, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya : A limonene-derivative from Sudachi peel activates sirt1 and improves lipid and glucose metabolism in high fat diet-fed mice., 欧州糖尿病学会, (巻), (号), (頁), (都市), Dec. 2016..[著者] ... Akiko Yano, Yuko Takahashi, Hiromi Moriguchi, Tomoaki Inazumi, Tomoaki Koga, Akira Otaka, Yukihiko Sugimoto and Hironobu Hojo : An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of Gas, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1862, No.6, 615-622, 2017..[著者] ... 灘井 亮, 原矢 佑樹, 西辻 和親, 内村 健治, 加藤 くみ子, 重永 章, 川上 徹, 大髙 章, 北條 裕信, 坂下 直実, 斎藤 博幸 : アルギニンペプチドのグリコサミノグリカン糖鎖を介した細胞膜透過機構に関する物理化学的解析, 日本薬学会第137年会, (巻), (号), (頁), 2017年3月..[著者] ... 猪熊 翼, 西田 航大, 重永 章, 大髙 章 : ペプチドへの直接的不斉反応を基盤とする新規非天然アミノ酸含有ペプチド合成テクノロジーの開発, 日本薬学会第137年会, 2017年3月..[著者] ... 川原 遥華, 奥平 桂一郎, 宮下 直樹, 津田 雄介, 森本 恭平, 辻 耕平, 重永 章, 大髙 章, 石田 竜弘 : 光応答性アポリポタンパク質の開発, 日本薬剤学会第32年会, 2017年5月..[著者] ... Tetsuro Yoshimaru, Keisuke Aihara, Masato Komatsu, Yosuke Matsushita, Yasumasa Okazaki, Shinya Toyokuni, Junko Honda, Mitsunori Sasa, Yasuo Miyoshi, Akira Otaka and Toyomasa Katagiri : Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics., Scientific Reports, Vol.7, No.1, 1821, 2017..[著者] ... 大髙 章 : 薬学基礎教育と臨床教育連携への提言-薬学における教養 化学-, 第2回日本薬学教育学会大会, (巻), (号), (頁), 2017年9月..[著者] ... 小久保 友絵, 池田 茉莉那, 渡部 匡史, 重永 章, 大髙 章, 藤室 雅弘 : 徳島大学化合物ライブラリーを用いた抗ヘルペスウイルス化合物の探索, 第67回日本薬学会近畿支部大会, (巻), (号), (頁), 2017年10月..[著者] ... 芳野 真奈, 宮本 理人, 山岡 朋美, 細井 麻由, 森崎 巧也, 安養寺 啓太央, 重永 章, 大髙 章, 土屋 浩一郎 : 骨格筋培養細胞でのレプチン作用におけるSIRT1の役割, 第56回 中国四国支部学術大会, (巻), (号), (頁), 2017年10月..[著者] ... 水口 智晴, 伊藤 恵理子, 中村 光希, 扇田 隆司, 馬場 照彦, 重永 章, 島内 寿德, 奥平 桂一郎, 大髙 章, 斎藤 博幸 : 脂質膜組成によるIowa変異型アポA-Iの線維化制御メカニズムの解明, 膜シンポジウム2017, 2017年11月..[著者] ... Yusuke Kato, Taiki Kohiki, Yusuke Nishikawa, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Yuji Shishido, Akira Shigenaga, Akira Otaka and Kiyoshi Fukui : Studies on binding molecules to D-amino acid oxidase using computational approaches, The 12th International Symposium of the Institute Network, Tokyo, (都市), Nov. 2017..[著者] ... 重永 章, 大髙 章 : アシル基転移反応を基盤とする標的タンパク質精製・機能解明ツールの開発, 日本薬学会第138年会(シンポジウム 中分子創薬研究のフロンティア), (巻), (号), (頁), 2018年3月..[著者] ... 小宮 千明, 月本 準, 森崎 巧也, 津田 雄介, 宮島 凜, 猪熊 翼, 重永 章, 伊藤 孝司, 大髙 章 : 均一修飾タンパク質の合成を指向したタンパク質C末端特異的活性化反応の開発, 日本薬学会第138年会, 2018年3月..[著者] ... Chiharu Mizuguchi, Mitsuki Nakamura, Naoko Kurimitsu, Takashi Ohgita, Kazuchika Nishitsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito : Effect of phosphatidylserine and cholesterol on membrane-mediated fibril formation by the N-terminal amyloidogenic fragment of apolipoprotein A-I, Scientific Reports, Vol.8, No.1, Articlenumber-5497, 2018..[著者] ... Hiroshi Inaba, Akihito Uemura, Kazushi Morishita, Taiki Kohiki, Akira Shigenaga, Akira Otaka and Kazunori Matsuura : Light-induced propulsion of a giant liposome driven by peptide nanofibre growth, Scientific Reports, Vol.8, No.1, articlenumber-6243, 2018..[著者] ... 宮下 直樹, 奥平 桂一郎, 川原 遥華, 津田 雄介, 森本 恭平, 辻 耕平, 重永 章, 大髙 章, 石田 竜弘 : 動脈硬化治療を指向した光制御型HDL構成ペプチドの開発, 日本薬剤学会第33年会, 2018年6月..[著者] ... 小宮 千明, 月本 準, 上田 将弘, 森崎 巧也, 猪熊 翼, 重永 章, 伊藤 孝司, 大髙 章 : 発現タンパク質に適用可能な新規チオエステル合成法の開発, 創薬懇話会 2018 in 志賀島, 2018年6月..[著者] ... 大川内 健人, 成瀬 公人, 重永 章, 大髙 章 : 新規チオール触媒を利用した環状ペプチド合成法の開発, 創薬懇話会 2018 in 志賀島, (巻), (号), (頁), 2018年6月..[著者] ... 榊原 拓哉, 猪熊 翼, 重永 章, 大髙 章, 山田 健一 : 安定なイミンを用いたα-アミノリン酸の実用的不斉合成, 創薬懇話会 2018 in 志賀島, (巻), (号), (頁), 2018年6月..[著者] ... Tsubasa Inokuma, Nishida Kodai, Akira Shigenaga, Ken-ichi Yamada and Akira Otaka : Novel methodology for the synthesis of-indolyl-glycine containing peptidevia direct asymmetric FriedelCrafts reactionto peptidyl imine, 35th European Peptide Symposium, Dublin, Ireland, Aug. 2018..[著者] ... 猪熊 翼, 岡田 和貴, 西田 航大, 重永 章, 大髙 章, 山田 健一 : ペプチドイミンに対する不斉1,2-付加を基盤とする非天然アミノ酸含有ペプチドの不斉合成, 第44回反応と合成の進歩シンポジウム, 2018年11月..[著者] ... 金山 忠史, 奥平 桂一郎, 大川内 健人, 清水 太郎, 重永 章, 大髙 章, 石田 竜弘 : 人工HDLの化学的性状と体内動態への影響に関する検討, 第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2018年11月..[著者] ... 榊原 拓哉, 猪熊 翼, 重永 章, 大髙 章, 山田 健一 : 非天然側鎖構造を有するα-アミノリン酸の実用的不斉合成, 第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2018年11月..[著者] ... 猪熊 翼, 西田 航大, 重永 章, 大髙 章, 山田 健一 : ペプチドへの直接的不斉反応によるインドリルグリシン含有ペプチドの合成, 日本薬学会第139年会, 2019年3月..[著者] ... 浜田 麻衣, 中山 淳, 重永 章, 辻 大輔, 寺町 順平, 安部 正博, 伊藤 孝司, 大髙 章, 難波 康祐 : 新規Ynone化合物の創生・評価, 日本薬学会第139年会, 2019年3月..[著者] ... 金山 忠史, 大川内 健人, 清水 太郎, 重永 章, 大髙 章, 石田 竜弘, 奥平 桂一郎 : 腫瘍DDSキャリアとしての人工HDLの調製および動態の評価, 日本薬剤学会第34年会, 2019年5月..[著者] ... Haruka Kawahara, Naoki Miyashita, Kohki Tachibana, Yusuke Tsuda, Kyohei Morimoto, Kouhei Tsuji, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida and Keiichiro Okuhira : A photo-activatable peptide mimicking functions of apolipoprotein A-I, Biological & Pharmaceutical Bulletin, Vol.42, No.6, 1019-1024, 2019..[著者] ... 猪熊 翼, 増井 香奈, 西田 航大, 重永 章, 大髙 章, 山田 健一 : ペプチドへの直接的不斉反応による異常アミノ酸含有ペプチド新規合成法の開発, 日本ケミカルバイオロジー学会第14回年会, 2019年6月..[著者] ... 浜田 麻衣, 森崎 巧也, 中山 淳, 寺町 順平, 辻 大輔, 重永 章, 山本 武範, 篠原 康雄, 大髙 章, 伊藤 孝司, 安部 正博, 難波 康祐 : 天然マクロライドの全合成が拓く新規多発性骨髄腫治療薬, 創薬懇話会2019 in 秋保(仙台), 2019年6月..[著者] ... Tsubasa Inokuma, Takuya Sakakibara, Takatoshi Someno, Kana Masui, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : Asymmetric Synthesis of α-Amino Phosphonic Acids Using Stable Imino Phosphonate as a Universal Precursor, Chemistry - A European Journal, Vol.25, 2019..[著者] ... 浜田 麻衣, 中山 淳, 中山 慎一朗, 寺町 順平, 辻 大輔, 重永 章, 安部 正博, 伊藤 孝司, 大髙 章, 難波 康祐 : 天然マクロライドの網羅的全合成が拓く新規多発性骨髄腫治療薬の開発研究, 2019年度第2回(第30回)日本プロセス化学会東四国フォーラムセミナー, 2019年10月..[著者] ... 榊原 拓哉, 猪熊 翼, 増井 香奈, 重永 章, 大髙 章, 山田 健一 : 安定なα-イミノリン酸エステルへの触媒的不斉付加を用いるキラルα-アミノリン酸の合成, 第45回反応と合成の進歩シンポジウム, 2019年10月..[著者] ... 有井 紗由季, 上田 将弘, 重永 章, 大髙 章, 石田 竜弘, 奥平 桂一郎 : プロテインノックダウン法を用いたチミジル酸合成酵素分解誘導剤開発, 第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2019年11月..[著者] ... Tsubasa Inokuma, Kohdai Nishida, Kana Masui, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : Chiral Phosphoric Acid-Catalyzed Asymmetric Mannich-Type Reaction Using Imino Peptide as Substrate, 第12回 有機触媒シンポジウム, Dec. 2019..[著者] ... Atsushi Nakayama, Akira Ohtani, Tsubasa Inokuma, Daisuke Tsuji, Haruka Mukaiyama, Nakayama Akira, Kouji Itou, Akira Otaka, Tanino Keiji and Kosuke Namba : Development of a 1,3a,6a-triazapentalene derivatives as a compact and thiol-specific fluorescent labeling reagent, Communications Chemistry, Vol.3, 6, 2020..[著者] ... 杉山 学, 大西 朗人, 森崎 巧也, 重永 章, 福島 圭穣, 大髙 章, 藤野 裕道 : inteinシステムを用いたプロスタノイドEP4受容体の局在解析を目指して, 日本薬学会第140年会, (巻), (号), (頁), 2020年3月..[著者] ... 安養寺 啓太央, 粟飯原 圭佑, 吉丸 哲郎, 西川 祐輔, 小松 正人, 重永 章, 片桐 豊雅, 大髙 章 : 乳がん細胞におけるBIG3-PHB2相互作用を標的とした高持続性架橋ペプチドの開発, 日本薬学会第140年会, 2020年3月..[著者]+[指導教員] ... 榊原 拓哉, 猪熊 翼, 増井 香奈, 重永 章, 大髙 章, 山田 健一 : 安定なα-イミノリン酸エステルの開発とキラルα-アミノリン酸の触媒的不斉合成への応用, 日本薬学会第140年会, 2020年3月..[著者] ... 常松 保乃加, 上田 智子, 左東 大輝, 小宮 千明, 重永 章, 大髙 章 : S-Oアシル転移を基盤とする環状デプシペプチドの合成, 日本薬学会第140年会, (巻), (号), (頁), 2020年3月..[著者]+[指導教員] ... 金山 忠史, 大川内 健人, 清水 太郎, 重永 章, 大髙 章, 石田 竜弘, 奥平 桂一郎 : 人工HDLの化学的性状と抗腫瘍効果への影響に関する検討, 日本薬学会第140年会, 2020年3月..[著者] ... 猪熊 翼, 増井 香奈, 西田 航大, 重永 章, 大髙 章, 山田 健一 : イミノペプチドへのインドール求核剤の不斉付加反応の開発, 第49回複素環化学討論会, 2020年9月..[著者] ... 有井 紗由季, 上田 将弘, 重永 章, 大髙 章, 猪熊 翼, 山田 健一, 石田 竜弘, 奥平 桂一郎 : 新規タンパク分解誘導剤によるチミジル酸合成酵素阻害メカニズムの解明, 日本薬剤学会第36年会, 2021年5月..[著者] ... 増井 香奈, 榊原 拓哉, 猪熊 翼, 重永 章, 大髙 章, 山田 健一 : キラルN-Npsイミノペプチドへのインドールのジアステレオ選択的付加, 第60回日本薬学会中国四国支部学術大会, 2021年10月..[著者] ... Masato Miyake, Mitsuaki Sobajima, Kiyoe Kurahashi, Akira Shigenaga, Masaya Denda, Akira Otaka, Tomohide Saio, Naoki Sakane, Hidetaka Kosako and Seiichi Oyadomari : Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells., Cell Chemical Biology, Vol.29, No.6, 996-1009.e9, 2022..[著者] ... 大西 朗人, 東山 晃子, 柳川 瞬矢, 清良 尚史, W John Regan, 大川内 健人, 傳田 将也, 福島 圭穣, 大髙 章, 藤野 裕道 : プロスタノイドEP4受容体の1アミノ酸変異によるシグナル伝達プロファイル変化, 第95回日本薬理学会年会，福岡, (巻), (号), (頁), 2022年3月..[著者] ... Misaki Yamasaki, Yuika Seto, Mizune Ohzono, Michiyasu Nakao, Akira Shigenaga, Akira Otaka, Shigeki Sano and Kentaro Kogure : Development of a novel tocopheryl ester for suppression of lipid accumulation without cytotoxicity by optimization of dicarboxylic ester moiety, Biochemistry and Biophysics Reports, Vol.31, 101329, 2022..[著者] ... Tsubasa Inokuma, MASUI Kana, Masaya Denda, Akira Otaka and Ken-ichi Yamada : Diastereoselective indolylation of N-2-nitrophenylsulfenyl iminopeptide for the synthesis of α-indolylglycine-containing peptide, 第59回ペプチド討論会, Oct. 2022..[著者] ... 福原 功起, 猪熊 翼, 増井 香奈, 傳田 将也, 大髙 章, 山田 健一 : N-2-Nitrophenylsulfenylイミノペプチドへのジアステレオ選択的インドリル化反応の開発, 日本薬学会第143年会, 2023年3月..[著者] ...
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Number of session users = 2, LA = 0.35, Max(EID) = 404207, Max(EOID) = 1095099.