『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
〔閲覧〕【著作】
--- テーブル「著作」（著作（著書，論文，レター，国際会議など））は研究業績にかかる著作（著書，論文，レター，国際会議など）を登録するテーブルです．
登録情報
抽出条件
| OWN= |  大髙 章 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.機能分子合成薬学])
|
|---|
登録情報の数
有効な情報: 418件 + 無効な情報: 13件 = 全ての情報: 431件
全ての有効な情報 (418件)
条件追加
[種別](著作の種別)による分類 : | ||||||||||||||||||||
[言語](著作の言語)による分類 : | ||||||||||||||||||||
[カテゴリ](著作のカテゴリ)による分類 : | ||||||||||||||||||||
[共著種別](共著の種別)による分類 : | ||||||||||||||||||||
[学究種別](著作の学究種別)による分類 : | ||||||||||||||||||||
[組織](著作の帰属する組織)による分類 :
| ||||||||||||||||||||
[年月日](発行年月日)による分類
| ||||||||||||||||||||
抽出結果のリスト
-
排列順: 項目表示: 大髙 章, 藤井 信孝 : シスチン含有ペプチドの新規合成法, 有機合成化学協会誌, Vol.48, (号), 658-671, 1990年7月. ... 大髙 章, 藤井 信孝 : ペプチド合成における最終脱保護材, 有機合成化学協会誌, Vol.48, (号), 1044-1045, 1990年11月. ... 大髙 章, 藤井 信孝 : ジスルフィド結合形成材, 有機合成化学協会誌, Vol.48, (号), 1010-1011, 1990年11月. ... 木曽 良明, 大髙 章 : 続 医薬品の開発 第14巻, --- ペプチド合成 ---, 株式会社 廣川書店, 東京, 1991年(0月). ... 藤井 信孝, 大髙 章 : 新生化学実験講座1 タンパク質6, --- 合成および発現 ---, 株式会社 東京化学同人, 東京, 1992年6月. ... Akira Otaka, Kengo Miyoshi, Midori Kaneko, Hirokazu Tamamura, Nobutaka Fujii, Motoyoshi Nomizu, Terrence R. Burke and Peter P. Roller : Development of Efficient Two-Step Deprotection Methodology for Dimethyl-Protected Phosphoamino Acid-Containing Peptide Resins and Its Application to the Practical Synthesis of Phosphopeptides, The Journal of Organic Chemistry, Vol.60, (号), 3967-3974, 1995. ... Kazuo Nakai, Toshiro Ibuka, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii and Yoshinori Yamamoto : A One-pot Aza-Payne Rearrangement-Epoxide Ring Opening Reaction of 2-Aziridinemethanols: A Regio- and Stereoselective Synthetic Route to Diastereomerically Pure 1,2-Amino Alocohols., Tetrahedron Letters, Vol.36, (号), 6247-6250, 1995. ... Nobutaka Fujii, Kazuo Nakai, Hirokazu Tamamura, Akira Otaka, Norio Mimura, Yoshihisa Miwa, Tooru Taga, Yoshinori Yamamoto and Toshiro Ibuka : SN2' Ring opening of aziridines bearing an α,β-unsaturated ester group with organocopper reagents. A new stereoselective synthetic route to (E)-alkene dipeptide isosteres., Journal of the Chemical Society, Perkin Transactions 1, (巻), (号), 1359-1371, 1995. ... Toshiro Ibuka, Kazuo Nakai, Hiromu Habashita, Yuka Hotta, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii, Norio Mimura, Yoshihisa Miwa, Tooru Taga, Yukiyasu Chounan and Yoshinori Yamamoto : Aza-Payne Rearrangement of Activated 2-Aziridinemethanols and 2,3-Epoxy Amines under Basic Conditions., The Journal of Organic Chemistry, Vol.60, No.7, 2044-2058, 1995. ... Nobutaka Fujii, Kazuo Nakai, Hiromu Habashita, Akira Otaka, Toshiro Ibuka, N Wada, Ryuichiro Doi, Ryo Hosotani, Masayuki Imamura, F Garrido, A Mann, Yukiyasu Chounan and Yoshinori Yamamoto : Highly Stereoselective Synthesis of (E)-Alkene Dipeptide Isosters via Organocopper Mediated 1,3-Chirality Transfer Reaction and Its Application to The Synthesis of Potent Bombesin Antagonist with No Agonistic Activity, Peptide 1994, (巻), (号), 77-78, 1995. ... Akira Otaka, Kengo Miyoshi, Terrence R. Burke-Jr, Peter P. Roller, Hirokazu Tamamura and Nobutaka Fujii : Synthesis and Biological Activity of Phosphatases Resistant Phosphoamino Acid Mimetics Containing Peptides, Peptide Chemistry 1994, (巻), (号), 9-12, 1995. ... Hirokazu Tamamura, Y Terakawa, Masao Masuda, Akira Otaka, H Murakami, Hideki Nakashima, S Horiuchi, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Structure-Activity Relationships of An Anti-HIV Peptide, T-22(No.2), Peptide Chemistry 1994, (巻), (号), 153-156, 1995. ... K. Suzuki, Toshiro Ibuka, Tooru Taga, Yoshihisa Miwa, Norio Mimura, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of L-Vinylglycine Derivatives, Peptide Chemistry 1994, (巻), (号), 165-168, 1995. ... Akira Otaka, Kengo Miyoshi, Terrence R. Burke-Jr, Peter P. Roller, Hirokazu Tamamura and Nobutaka Fujii : Application of Ser(OPO3Me2) Derivatives to The Synthesis of Phosphoserine-containing peptide, Peptide Chemistry 1994, (巻), (号), 193-196, 1995. ... Akira Otaka, Kengo Miyoshi, Peter P. Roller, Terrence R. Burke-Jr, Hirokazu Tamamura and Nobutaka Fujii : Practical Synthesis of Phosphopeptides Using Dimethyl-protected Phosphoamino Acid Derivatives., Journal of the Chemical Society. Chemical Communications, Vol.3, (号), 387-389, 1995. ... Hirokazu Tamamura, Akira Otaka, W Takada, Y Terakawa, H Yoshizawa, Masao Masuda, Toshiro Ibuka, Tsutomu Murakami, Hideki Nakashima, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Solution-phase synthesis of an anti-human immunodeficiency virus peptide, T22 ([Tyr5,12,Lys7]-polyphemusin II), and the modification of Trp by the p-methoxybenzyl group of Cys during trimethylsilyl trifluoromethanesulfonate deprotection., Chemical & Pharmaceutical Bulletin, Vol.43, No.1, 12-18, 1995. ... Ronald L. Wange, Noah Isakov, Terrence Burke R. Jr., Akira Otaka, Peter P. Roller, Julian D. Watts, Ruedi Aebersold and Lawrence E. Samelson : F2(Pmp)2-TAM3, a Novel Competitive Inhibitor of the Binding of ZAP-70 to the T Cell Antigen Receptor, Blocks Early T Cell Signaling, The Journal of Biological Chemistry, Vol.270, No.2, 944-948, 1995. ... Akira Otaka, Kengo Miyoshi, Hideki Kubota, Terrence R. Burke-Jr, Peter P. Roller, Hirokazu Tamamura and Nobutaka Fujii : Synthesis and application of N-Boc-L-2-amino-4-(diethylphosphono)-4,4-difluorobutanoic acid for solid-phase synthesis of nonhydrolyzable phosphoserine peptide analogues, Tetrahedron Letters, Vol.36, No.6, 927-930, 1995. ... Hirokazu Tamamura, Akira Otaka, J Nakamura, K Okubo, T Koide, K Ikeda, Toshiro Ibuka and Nobutaka Fujii : Disulfide Bond-forming Reaction using Dimethyl sulfoxide/aqueous HCl System and Its Application to Regioselective Two Disulfide Bond Formation., International Journal of Peptide and Protein Research, Vol.45, No.4, 312-319, 1995. ... Hirokazu Tamamura, Tsutomu Murakami, S Horiuchi, K Sugihara, Akira Otaka, W Takada, Toshiro Ibuka, Michinori Waki, Naoki Yamamoto and Nobutaka Fujii : Synthesis of Protegrin-related Peptides and their Antibacterial and Anti-Human Immunodeficiency Virus Activity., Chemical & Pharmaceutical Bulletin, Vol.43, No.5, 853-858, 1995. ... Hirokazu Tamamura, K Sugihara, Akira Otaka, Tsutomu Murakami, S Horiuchi, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Synthesis of Protegrin-related Peptides and their Antibacterial and Anti-HIV Activity., Peptide Chemistry 1994, (巻), (号), 345-348, 1995. ... Motoyoshi Nomizu, W H. Kim, Keizo Yamamura, Atsushi Utani, Sang-Yong Song, Akira Otaka, Peter P. Roller, Hynda K. Kleinman and Yoshihiko Yamada : Identification of Cell Binding Sites in the Laminin a1 Chain Carboxyl-terminal Globular Domain by Systematic Screening of Synthetic Peptides., The Journal of Biological Chemistry, Vol.270, No.35, 20583-20590, 1995. ... Li Chen, Li Wu, Akira Otaka, Mark S Smyth, Peter P Roller, Terrence R Burke, Den Jen Hertog and Zhong-Yin Zhang : Why Is Phosphonodifluoromethyl Phenylalanine a More Potent Inhibitory Moiety Than Phosphonomethyl Phenylalanine Toward Protein-Tyrosine Phosphatases, Biochemical and Biophysical Research Communications, Vol.216, No.3, 976-984, 1995. ... Bin Ye, Akira Otaka and Terrence R. Burke-Jr : Preparation of Na-Boc 4-O-Diethylphosphono-L-azatyrosine, a Reagent Potentially Useful for the Synthesis of Signal Transduction Related Peptides., Synlett, (巻), (号), 459-460, 1996. ... Akira Otaka, Kengo Miyoshi, Hirokazu Tamamura, Peter P. Roller, Terrence R. Burke-Jr and Nobutaka Fujii : Development of a Practical Synthetic Methodology Using Dimethylphosphono Amino Acid for Phosphopeptides, Peptides: Chemistry, Structure and Biology, (巻), (号), 442-443, 1996. ... Motoyoshi Nomizu, Atsushi Utani, Akira Otaka, Peter P. Roller and Yoshihiko Yamada : Assembly and Stability of Double- and Triple-stranded α-Helical Coiled-coil Structures of Laminin Peptides, Peptides: Chemistry, Structure and Biology, (巻), (号), 487-488, 1996. ... Kengo Miyoshi, Akira Otaka, Midori Kaneko, Hirokazu Tamamura and Nobutaka Fujii : Practical Phosphopeptides Synthesis Using Dimethylphosphono Amino Acids (No.2), Peptide Chemistry 1995, (巻), (号), 25-28, 1996. ... Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Identification of Binding Proteins of an Anti-HIV Peptide,T22, Peptide Chemistry 1995, (巻), (号), 237-240, 1996. ... W Takada, Akira Otaka, Kazuo Nakai, Toshiro Ibuka, Koji Fujimoto, M Wada, Ryuichiro Doi, Ryo Hosotani, S Higashide, Masayuki Imamura and Nobutaka Fujii : Synthesis and Biological Activity of Bombesin Analogues Containing (E)-Alkene Dipeptide Isosteres, Peptide Chemistry 1995, (巻), (号), 493-496, 1996. ... Joseph J. Barchi-Jr, Motoyoshi Nomizu, Akira Otaka, Peter P. Roller and Terrence R. Burke-Jr : Conformational Analysis of Cyclic Hexapeptides Designed as Constrained Ligands for the SH2 Domain of the p85 Subunit of Phosphatidylinositol-3-OH Kinase., Biopolymers, Vol.38, No.2, 191-208, 1996. ... Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Tsunehito Ishihara, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Interaction of an Anti-HIV Peptide, T22, with GP120 and CD4, Biochemical and Biophysical Research Communications, Vol.219, No.2, 555-559, 1996. ... Motoyoshi Nomizu, Atsushi Utani, Konrad Beck, Akira Otaka, Peter P. Roller and Akira Otaka : Mechanism of Laminin Chain Assembly into a Triple-Stranded Coiled-Coil Structure, Biochemistry, Vol.35, No.9, 2885-2893, 1996. ... Hirokazu Tamamura, Tsunehito Ishihara, Akira Otaka, Tsutomu Murakami, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Analysis of the interaction of an anti-HIV peptide, T22 ([Tyr5, 12, Lys7]-polyphemusin II), with gp120 and CD4 by surface plasmon resonance, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol.1298, No.1, 37-44, 1996. ... Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Toshiro Ibuka, Kyoko Sakano, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : An Anti-HIV Peptide, T22, Forms a Highly Active Complex with Zn(II), Biochemical and Biophysical Research Communications, Vol.229, No.2, 648-652, 1996. ... Hirokazu Tamamura, Masaki Yamashita, Hiroyuki Muramatsu, Hiroaki Ohno, Tohiro Ibuka, Akira Otaka and Nobutaka Fujii : Regiospecific ring-opening reactions of aziridines bearing an α,β-unsaturated ester group with trifluoroacetic acid or methanesulfonic acid: application to the stereoselective synthesis of (E)-alkene dipeptide isosteres, Chemical Communications, (巻), (号), 2327-2328, 1997. ... 大髙 章 : タンパク質化学 第11巻, --- ホルモン系タンパク質およびポリアミン ---, 株式会社 廣川書店, 東京, 1997年(0月). ... Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Identification of a Polyphemusin Analog (T22)- Zn(II) complex by Mass Spectrometric Analysis and Its Anti-HIV Activity, Peptide Chemistry 1996, (巻), (号), 269-272, 1997. ... Hiroaki Ohno, Norio Mimura, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii, Toshiro Ibuka, Isao Shimizu, Akiharu Satake and Yoshinori Yamamoto : Palladium-Catalyzed Reductive Ring Opening with Formic Acid of Aziridines Bearing an α,β-Unsaturated Ester Group, Tetrahedron, Vol.53, No.38, 12933-12946, 1997. ... Hiroshi Aoyama, Norio Mimura, Hiroaki Ohno, Kiyonori Ishii, Ayako Toda, Hirokazu Tamamura, Akira Otaka, Nobutaka Fujii and Toshiro Ibuka : Regio- and stereoselectivity in reactions of 2,3-cis- and trans-3-alkyl-2-vinylaziridines with organocopper reagents: Importance of 2,3-cis-stereochemistry in controlling selectivity, Tetrahedron Letters, Vol.38, No.42, 7383-7386, 1997. ... Motoyoshi Nomizu, Yuichiro Kuratomi, Sang-Yong Song, M. Lourdes Ponce, Matthew P. Hoffman, Sharon K. Powell, Kengo Miyoshi, Akira Otaka, Hynda K. Kleinman and Yoshihiko Yamada : Identification of Cell Binding Sequences in Mouse Laminin 1 Chain by Systematic Peptide Screening, The Journal of Biological Chemistry, Vol.272, No.51, 32198-32205, 1997. ... Hirokazu Tamamura, Tsunehito Ishihara, Hiromi Oyake, Makoto Imai, Akira Otaka, Toshiro Ibuka, Rieko Arakaki, Hideki Nakashima, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Convenient one-pot synthesis of cystine-containing peptides using the trimethylsilyl chloride dimethyl sulfoxide/trifluoroacetic acid system and its application to the synthesis of bifunctional anti-HIV compounds1, Journal of the Chemical Society, Perkin Transactions 1, (巻), (号), 495-500, 1998. ... Hirokazu Tamamura, F Matsumoto, Kyoko Sakano, Akira Otaka, Toshiro Ibuka and Nobutaka Fujii : Unambiguous Synthesis of Stromal Cell-derived Factor-1 by Regioselective Disulfide Bond Formation Using a DMSO-aqueous HCl System, Chemical Communications, (巻), No.1, 151-152, 1998. ... Akira Otaka, Kengo Miyoshi, Midori Kaneko, Terrence Jr R. Burke, Peter P. Roller, Hirokazu Tamamura and Nobutaka Fujii : Development of New Efficient Deprotecting Methodologies for The Synthesis of Phosphoamino Acids-Containing Peptides, Peptides 1996, (巻), (号), 701-702, 1998. ... Atsushi Kosaki, Kazunori Yamada, Junko Suga, Akira Otaka and Hideshi Kuzuya : 14-3-3β Protein Associates with Insulin Receptor Substrate 1 and Decreases Insulin-stimulated Phosphatidylinositol 3-Kinase Activity in 3T3L1 Adipocytes, The Journal of Biological Chemistry, Vol.273, No.2, 940-944, 1998. ... Hirokazu Tamamura, Rieko Arakaki, Hanae Funakoshi, Makoto Imai, Akira Otaka, Toshiro Ibuka, Hideki Nakashima, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Effective lowly cytotoxic analogs of an HIV-cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II), Bioorganic & Medicinal Chemistry, Vol.6, No.2, 231-238, 1998. ... Hirokazu Tamamura, Michinori Waki, Makoto Imai, Akira Otaka, Toshiro Ibuka, Koji Waki, Kenji Miyamoto, Akiyoshi Matsumoto, Tsutomu Murakami, Hideki Nakashima, Naoki Yamamoto and Nobutaka Fujii : Downsizing of an HIV cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-Polyphemusin II), with the maintenance of anti-HIV activity and solution structure, Bioorganic & Medicinal Chemistry, Vol.6, No.4, 473-479, 1998. ... Hirokazu Tamamura, Makoto Imai, Tsunehito Ishihara, Masao Masuda, Hanae Funakoshi, Hiromi Oyake, Tsutomu Murakami, Rieko Arakaki, Hideki Nakashima, Akira Otaka, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Pharmacophore identification of a chemokine receptor (CXCR4) antagonist, T22 ([Tyr5,12, Lys7]-polyphemusin II), which specifically blocks T cell-line-tropic HIV-1 infection, Bioorganic & Medicinal Chemistry, Vol.6, No.7, 1033-1041, 1998. ... Motoyoshi Nomizu, Yuichiro Kuratomi, Katherine M. Malinda, Sang Yong Song, Kengo Miyoshi, Akira Otaka, Sharon K. Powell, Matthew P. Hoffman, Hynda K. Kleinman and Yoshihiko Yamada : Cell Binding Sequences in Mouse Laminin 1 Chain, The Journal of Biological Chemistry, Vol.273, No.49, 32491-32499, 1998. ... Hirokazu Tamamura, Younong Xu, Toshio Hattori, Xiaoyan Zhang, Rieko Arakaki, Kenji Kanbara, Akane Omagari, Akira Otaka, Toshiro Ibuka, Naoki Yamamoto, Hideki Nakashima and Nobutaka Fujii : A Low-Molecular-Weight Inhibitor against the Chemokine Receptor CXCR4: A Strong Anti-HIV Peptide T140, Biochemical and Biophysical Research Communications, Vol.253, No.3, 877-882, 1998. ... 大髙 章, 相本 三郎 : 構造生物学の方法論の新しい展開, --- リン酸化ペプチドの化学合成 ---, 蛋白質 核酸 酵素, Vol.44, (号), 302-309, 1999年(0月). ... Akira Otaka, Etsuko Mitsuyama, Shinya Oishi, Kengo Miyoshi, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of Nonhydrolyzable Phosphothreonine Mimetic and Its Practical Application to Peptide Synthesis, Peptide 1998, (巻), (号), 264-265, 1999. ... H. Mariko, Hirokazu Tamamura, Akira Otaka, Toshiro Ibuka, Rieko Arakaki, Hideki Nakashima and Nobutaka Fujii : Ring-closing Metathesis Produced a CXCR4 Antagonist with Anti-HIV Activity, Peptide 1998, (巻), (号), 662-663, 1999. ... Hirokazu Tamamura, Tsunehito Ishihara, Hiromi Oyake, Akira Otaka and Nobutaka Fujii : Convenient One-pot Synthesis of Cystine-containing Peptides from Protected Peptidyl Resins and Its Application to the Synthesis of Bifunctional Anti-HIV Compounds, Peptide Science Present and Future, (巻), (号), 41-43, 1999. ... Hirokazu Tamamura, Masaki Yamashita, Hiroyuki Muramatsu, Toshiro Ibuka, Akira Otaka and Nobutaka Fujii : Stereoselctive Synthesis of Two Type (E)-Alkene Dipeptide Isosteres from a Single Substrate of β-Aziridinyl-α ,β-enoate, Peptide Science Present and Future, (巻), (号), 44-46, 1999. ... Hirokazu Tamamura, F Matsumoto, Kyoko Sakano, Akira Otaka, Tsutomu Murakami, Hideki Nakashima, Michinori Waki, Akiyoshi Matsumoro, Naoki Yamamoto and Nobutaka Fujii : An Anti-HIV Peptide T22 is Confirmed to Be a Selective CXCR4/Fusin Inhibitor by Comparative Inhibition Study of a Chemokine SDF-1,Synthesized by Regioselective Disulfide Bond Formation, Peptide Science Present and Future, (巻), (号), 398-402, 1999. ... Hirokazu Tamamura, Michinori Waki, Akira Otaka, Tsutomu Murakami, Hideki Nakashima, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : HIV-cell Fusin Inhibitor T22([Tyr5,12,Lys7]-polyphemusin II),and Its Related Compounds, Peptide Science Present and Future, (巻), (号), 424-426, 1999. ... Hirokazu Tamamura, Michinori Waki, Akira Otaka, Tsutomu Murakami, Hideki Nakashima, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Efficient Analog of An Anti-HIV Peptide,T22 ([Tyr5,12,Lys7]-polyphemusin II),Having Low Cytotoxicity, Peptide Science Present and Future, (巻), (号), 427-429, 1999. ... Akira Otaka, Y. Umeda, Hirokazu Tamamura, Toshiro Ibuka and Nobutaka Fujii : Synthesis of Protected 2,3-Epoxy Amines Utilizing Aza-Payne Rearrangement of Activated 2-Aziridinemethanols Under Basic Conditions, Peptide Science Present and Future, (巻), (号), 504-506, 1999. ... Kengo Miyoshi, Akira Otaka, Midori Kaneko, Hirokazu Tamamura and Nobutaka Fujii : Convenient Preparation of Phosphopeptide Fagments Using High TFMSA System and Its Application to Synthesis of Long Chain Phosphopeptides, Peptide Science Present and Future, (巻), (号), 507-509, 1999. ... Hirokazu Tamamura, Akane Omagari, Tsutomu Murakami, Rieko Arakaki, Younong Xu, Toshio Hattori, Michinori Waki, Akiyoshi Matsumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : HIV-cell Fusion Inhibitors:T22 and Its Downsized Analogs with High Activity, Peptide Science 1998, (巻), (号), 49-52, 1999. ... Akira Otaka, Etsuko Mitsuyama, Kengo Miyoshi and Nobutaka Fujii : Synthesis of Nonhydrolyzable Phosphthreonine Derivatives and Their Practical Application to Peptide Synthesis, Peptide Science 1998, (巻), (号), 137-140, 1999. ... M Hirohashi, Shinya Oishi, Tsutomu Murakami, Rieko Arakaki, Younong Xu, Toshio Hattori, Naoki Yamamoto, Takatomo Koshiba, Ryo Hosotani, Masayuki Imamura, T Mio, S Nagai, T Izumi, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Synthesis of a CC Chemokine vMIP-II,Encoded by Kaposi's Sarcoma-associated Herpesvirus and Its Biological Activity, Peptide Science 1998, (巻), (号), 285-288, 1999. ... Shunji Kanaoka, Seiji Yamasaki, Takashi Okino, Naoya Inoue, Yutaka Shimada, Midori Kaneko, Akira Otaka, Nobutaka Fujii and Masayuki Imamura : Induction of human leukocyte antigen (HLA)-A2-restricted and MAGE-3-gene-derived peptide-specific cytolytic T lymphocytes using cultured dendritic cells from an HLA-A2 esophageal cancer patient, Journal of Surgical Oncology, Vol.71, No.1, 16-21, 1999. ... Hirokazu Tamamura, Masaki Yamashita, Yutaka Nakajima, Kyoko Sakano, Akira Otaka, Hiroaki Ohno, Toshiro Ibuka and Nobutaka Fujii : Regiospecific ring-opening reactions of β-aziridinyl α,β-enoates with acids: application to the stereoselective synthesis of a couple of diastereoisomeric (E)-alkene dipeptide isosteres from a single β-aziridinyl α,β-enoate and to the convenient preparation of amino alcohols bearing α,β-unsaturated ester groups, Journal of the Chemical Society, Perkin Transactions 1, (巻), (号), 2983-2996, 1999. ... Yoshihiro Kuroda, Yoshitaka Maeda, Kazuhide Miyamoto, Kazufumi Tanaka, Kenji Kanaori, Akira Otaka, Nobutaka Fujii and Terumichi Nakagawa : 1H-NMR and Circular Dichroism Spectroscopic Studies on Changes in Secondary Structures of the Sodium Channel Inactivation Gate Peptides as Caused by the Pentapeptide KIFMK, Biophysical Journal, Vol.77, No.3, 1363-1373, 1999. ... Akira Otaka, Etsuko Mitsuyama, Hideaki Watanabe, Hirokazu Tamamura and Nobutaka Fujii : Development of new methodology for the synthesis of functionalized α-fluorophosphonates and its practical application to the preparation of phosphopeptide mimetics, Chemical Communications, (巻), (号), 1081-1082, 2000. ... 大髙 章 : 高付加価値ペプチド合成のための最終脱保護法の開発と細胞内情報伝達機構解明への展開研究, 薬学雑誌, Vol.120, (号), 54-67, 2000年(0月). ... Motoyoshi Nomizu, Yuichiro Kuratomi, Akira Otaka, Hynda K. Kleinman, Yoshihiko Yamada and Norio Nishi : Identification of Biologically Active Peptides in Laminin-1, Peptide Science 1999, (巻), (号), 21-24, 2000. ... Nobutaka Fujii, M Hirohashi, Shinya Oishi, M Akaji, Akane Omagari, Akira Otaka and Toshiro Ibuka : Application of Ring Closing Olefin Metathesis to the Conformational Restriction of Biological Active Peptide, Peptide Science 1999, (巻), (号), 193-194, 2000. ... Akira Otaka, Y. Umeda, Shinya Oishi, Toshiro Ibuka and Nobutaka Fujii : New Strategy for the Synthesis of Aspartyl Protease Inhibitor Based on "Aza-Payne Rearrangement", Peptide Science 1999, (巻), (号), 195-196, 2000. ... Motoyoshi Nomizu, Yuichiro Kuratomi, M. Lourdes Ponce, Sang Yong Song, Kengo Miyoshi, Akira Otaka, Sharon K. Powell, Matthew P. Hoffman, Hynda K. Kleinman and Yoshihiko Yamada : Cell Adhesive Sequences in Mouse Laminin β1 Chain, Archives of Biochemistry and Biophysics, Vol.378, No.2, 311-320, 2000. ... Kengo Miyoshi, Akira Otaka, Midori Kaneko, Hirokazu Tamamura and Nobutaka Fujii : A New Practical Strategy for the Synthesis of Long-chain Phosphopeptide, Chemical & Pharmaceutical Bulletin, Vol.48, No.88, 1230-1233, 2000. ... Akira Otaka, Etsuko Mitsuyama, Takayoshi Kinoshita, Hirokazu Tamamura and Nobutaka Fujii : Stereoselective Synthesis of CF2-Substituted Phosphothreonine Mimetics and Their Incorporation into Peptides Using Newly Developed Deprotection Procedures, The Journal of Organic Chemistry, Vol.65, No.16, 4888-4899, 2000. ... Yoshihiro Kuroda, Kazuhide Miyamoto, M Matsumoto, Yishitaka Maeda, Kenji Kanaori, Akira Otaka, Nobutaka Fujii and Terumichi Nakagawa : Structural study of the sodium channel inactivation gate peptide including an isoleucine-phenylalanine-methionine motif and its analogous peptide (phenylalanine/glutamine) in trifluoroethanol solutions and SDS micelles, The Journal of Peptide Research, Vol.56, No.3, 172-184, 2000. ... Yoshihiro Kuroda, Kazuhide Miyamoto, Kazufumi Tanaka, Yoshitaka Maeda, J Ishikawa, R Hinata, Akira Otaka, Nobutaka Fujii and Terumichi Nakagawa : Interactions between Local Anesthetics and Na+ Channel Inactivation Gate Peptides in Phosphatidylserine Suspensions as Studied by 1H-NMR Spectroscopy, Chemical & Pharmaceutical Bulletin, Vol.48, No.9, 1293-1298, 2000. ... Yoshimi Sagawa, Yoshiyuki Yoshimura, Akira Otaka and Takashi Yamauchi : Ca2+-independent activity of Ca2+/calmodulin-dependent protein kinase II involved in stimulation of neurite outgrowth in neuroblastoma cells, Brain Research, Vol.881, No.2, 165-175, 2000. ... Koji Fujimoto, Ryo Hosotani, Yoshiharu Miyamoto, Ryuichiro Doi, Takatomo Koshiba, Akira Otaka, Nobutaka Fujii, Robert D. Beauchamp and Masayuki Imamura : Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16(INK4A) fusion peptide in pancreatic cancer cells, Cancer Letters, Vol.159, No.2, 151-158, 2000. ... Hirokazu Tamamura, Akane Omagari, Shinya Oishi, Taisei Kanamoto, Naoki Yamamoto, Stephen C. Peiper, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes, Bioorganic & Medicinal Chemistry Letters, Vol.10, No.23, 2633-2637, 2000. ... Shinya Oishi, Hirokazu Tamamura, Masaki Yamashita, Yoshihiko Odagaki, Nobuyuki Hamanaka, Akira Otaka and Nobutaka Fujii : Stereoselective synthesis of a set of two functionalized (E)-alkene dipeptide isosteres of L-amino acid-L-Glu and L-amino acid-D-Glu, Journal of the Chemical Society, Perkin Transactions 1, (巻), (号), 2445-2451, 2001. ... Akira Otaka, Hideaki Watanabe, Junko Watanabe, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of Fluoroalkene Dipeptide Isosteres Utilizing Organometallic Reagents, Peptides: The Wave of the Future, (巻), (号), 606-607, 2001. ... Akira Otaka, Etsuko Mitsuyama, Hideaki Watanabe, Hirokazu Tamamura, T Hayashi, K. Nakao and Nobutaka Fujii : Stereoselective Synthesis of CF2 or CHF-Substituted Phosphoamino Acids and Their Incorporation into Peptide, Peptide Science 2000, (巻), (号), 17-20, 2001. ... Akane Omagari, Hirokazu Tamamura, Shinya Oishi, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Development of Specific CXCR4 Inhibitors Based on an anti-HIV peptide, T140, and Their Structure-Activity Relationship Study, Peptide Science 2000, (巻), (号), 129-132, 2001. ... Shinya Oishi, Takae Kamano, Ayumu Niida, M. Kwaguchi, Ryo Hosotani, Masayuki Imamura, N. Yawata, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Efficient Synthesis of Cyclic RGD Pseudopeptide with (E)-Alkene Dipeptide Isosteres and Its Biological Activity, Peptide Science 2000, (巻), (号), 249-250, 2001. ... Akira Otaka, Hideaki Watanabe, Etsuko Mitsuyama, Akira Yukimasa, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of (Z)-fluoroalkene dipeptide isosteres utilizing organocopper-mediated reduction of γ,γ-difluoro-α,β-enoates, Tetrahedron Letters, Vol.42, No.2, 285-287, 2001. ... Hirokazu Tamamura, Makiko Sugioka, Yoshihiko Odagaki, Akane Omagari, Yukiko Kan, Shinya Oishi, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Nobuyuki Hamanaka, Akira Otaka and Nobutaka Fujii : Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity, Bioorganic & Medicinal Chemistry Letters, Vol.11, No.3, 359-362, 2001. ... Terrence R Burke-Jr, Jun-Zhu Yao, Bin Ye, Kengo Miyoshi, Akira Otaka, Li Wu and Zhong-Yin Zhang : Phospho-azatyrosine, a less effective protein-tyrosine phosphatase substrate than phosphotyrosine, Bioorganic & Medicinal Chemistry Letters, Vol.11, No.10, 1265-1268, 2001. ... Hirokazu Tamamura, Akane Omagari, Kenichi Hiramatsu, Kazuyo Gotoh, Taisei Kanamoto, Younong Xu, Eiichi Kodama, Masao Matsuoka, Toshio Hattori, Naoki Yamamoto, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140, Bioorganic & Medicinal Chemistry Letters, Vol.11, No.14, 1897-1902, 2001. ... Hirokazu Tamamura, Akane Omagari, Kenichi Hiramatsu, Taisei Kanamoto, Kazuyo Gotoh, Kenji Kanbara, Naoki Yamamoto, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Synthesis and evaluation of bifunctional anti-HIV agents based on specific CXCR4 antagonists-AZT conjugation, Bioorganic & Medicinal Chemistry, Vol.9, No.8, 2179-2187, 2001. ... Akira Otaka, Hideaki Watanabe, Akira Yukimasa, Shinya Oishi, Hirokazu Tamamura and Nobutaka Fujii : New access to α-substituted (Z)-fluoroalkene dipeptide isosteres utilizing organocopper reagents under `reduction oxidative alkylation (R-OA)' conditions, Tetrahedron Letters, Vol.42, No.32, 5443-5446, 2001. ... Toshiaki Hara, Yasuyuki Mitani, Kyoko Tanaka, Natsuko Uematsu, Asako Takakura, Tomoya Tachi, Hiroaki Kodama, Michio Kondo, Harumi Mori, Akira Otaka, Nobutaka Fujii and Katsumi Matsuzaki : Heterodimer Formation between the Antimicrobial Peptides Magainin 2 and PGLa in Lipid Bilayers: A Cross-Linking Study, Biochemistry, Vol.40, No.41, 12395-12399, 2001. ... Hirokazu Tamamura, Tadakazu Hori, Akira Otaka and Nobutaka Fujii : Efficient stereoselective synthesis of peptidomimetics containing hydroxyethylamine dipeptide isosteres utilizing the aza-Payne rearrangement and O, N-acyl transfer reactions, Journal of the Chemical Society, Perkin Transactions 1, Vol.5, 577-580, 2002. ... Shinya Oishi, Ayumu Niida, Takae Kamano, Yoshihisa Miwa, Tooru Taga, Yoshihiko Odagaki, Nobuyuki Hamanaka, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Regio- and stereoselective ring-opening of chiral 1,3-oxazolidin-2-one derivatives by organocopper reagents provides novel access to di-, tri- and tetra-substituted alkene dipeptide isosteres, Journal of the Chemical Society, Perkin Transactions 1, (巻), (号), 1786-1793, 2002. ... Shinya Oishi, Takae Kamano, Ayumu Niida, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Organocopper-mediated Stereoselective Synthesis of multi-Substituted Alkene Dipeptide Isosteres and Application to cyclic RGD Peptides, Peptide 2002, (巻), (号), 244-245, 2002. ... Akira Otaka, Miki Nakamura, Eiichi Kodama, Susumu Uchiyama, Hirokazu Tamamura, Yuji Kobayashi, Masao Matsuoka and Nobutaka Fujii : Artificial Remodeling of gp41-C34 Peptide Leads to Effective HIV Fusion Inhibitor with High anti-HIV Activity, Peptide 2002, (巻), (号), 838-839, 2002. ... Kenichi Hiramatsu, Hirokazu Tamamura, Akane Omagari, Hideki Nakashima, Younong Xu, Masao Matsuoka, Akira Otaka and Nobutaka Fujii : Synthesis of Novel Anti-HIV Peptides Based on a CXCR4 Antagonist, T140, and Their SAR Study, Peptide Science 2001, (巻), (号), 175-178, 2002. ... Ayumu Niida, Shinya Oishi, Takae Kamano, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Synthesis of ψ[(E)-CMe=CMe]- and ψ[(E)-CMe=CH]-type Alkene Dipeptide Isosteres from a Chiral Amino Acide, Peptide Science 2001, (巻), (号), 237-240, 2002. ... Yoshihito Taniguchi, Helena Karlström, Johan Lundkvist, Tomohiko Mizutani, Akira Otaka, Monica Vestling, Alan Bernstein, Dorit Donoviel, Urban Lendahl and Tasuku Honjo : Notch receptor cleavage depends on but is not directly executed by presenilins, Proceedings of the National Academy of Sciences of the United States of America, Vol.99, No.6, 4014-4019, 2002. ... Junko Watanabe, Akira Otaka, Hideaki Watanabe, Akira Yukimasa, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of Fluoroalkene Dipeptide Isosteres Utilizing Organocopper or SmI2 Reagents, Peptide Science 2001, Vol.2001, No.0, 29-32, 2002. ... Miki Nakamura, Akira Otaka, Eiichi Kodama, Masao Matsuoka, Susumu Uchiyama, Syota Nakamura, Yuji Kobayashi, Hirokazu Tamamura and Nobutaka Fujii : Design and Synthesis of Highly Active Anti-HIV Peptide Based on gp41-C34 Peptide, Peptide Science 2001, Vol.2001, No.0, 73-76, 2002. ... Shinya Oishi, Takae Kamano, Ayumu Niida, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type Dipeptide Isosteres and Their Application to a Cyclic RGD Peptide, Peptide Science 2001, Vol.2001, No.0, 241-244, 2002. ... K. Takeshima, A. Chikushi, S Kobayashi, L. Kyung-Kwon, S Yonehara, Akira Otaka, Nobutaka Fujii and K Matsuzaki : Translocation of Basic Peptides through Human Cell Membranes, Peptide Science 2001, Vol.2001, No.0, 321-324, 2002. ... Hirokazu Tamamura, Kenichi Hiramatsu, Kazuhide Miyamoto, Akane Omagari, Shinya Oishi, Hideki Nakashima, Naoki Yamamoto, Yoshihiro Kuroda, Terumichi Nakagawa, Akira Otaka and Nobutaka Fujii : Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: The insertion of an (E)-alkene dipeptide isostere into the βII' -turn moiety, Bioorganic & Medicinal Chemistry Letters, Vol.12, No.6, 923-928, 2002. ... Ryo Hosotani, Yoshiharu Miyamoto, Koji Fujimoto, Ryuichiro Doi, Akira Otaka, Nobutaka Fujii and Masayuki Imamura : Trojan p16 Peptide Suppresses Pancreatic Cancer Growth and Prolongs Survival in Mice, Clinical Cancer Research, Vol.8, No.4, 1271-1276, 2002. ... Shinya Oishi, Ayumu Niida, Takae Kamano, Yoshihiko Odagaki, Hirokazu Tamamura, Akira Otaka, Nobuyuki Hamanaka and Nobutaka Fujii : Diastereoselective synthesis of psi[(E)-CMe=CH]- and psi[(E)-CMe=CMe]- type dipeptide isosteres based on organocopper-mediated anti-S(N)2' reaction, Organic Letters, Vol.4, No.7, 1055-1058, 2002. ... Shinya Oishi, Takae Kamano, Ayumu Niida, Yoshihiko Odagaki, Hirokazu Tamamura, Akira Otaka, Nobuyuki Hamanaka and Nobutaka Fujii : Diastereoselective synthesis of psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type dipeptide isosteres by organocopper-mediated anti-S(N)2' reaction, Organic Letters, Vol.4, No.7, 1051-1054, 2002. ... Hirokazu Tamamura, Akane Omagari, Kenichi Hiramatsu, Shinya Oishi, Hiromu Habashita, Taisei Kanamoto, Kazuyo Gotoh, Naoki Yamamoto, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Certification of the Critical Importance of L-3-(2-Naphthyl)alanine at Position 3 of a Specific CXCR4 Inhibitor, T140, Leads to an Exploratory Performance of Its Downsizing Study, Bioorganic & Medicinal Chemistry, Vol.10, No.5, 1417-1426, 2002. ... Masayoshi Makino, Ikuko Okazaki, Shingo Kasai, Norio Nishi, Maria Bougaeva, Benjamin S. Weeks, Akira Otaka, Peter K. Nielsen, Yoshihiko Yamada and Motoyoshi Nomizu : Identification of Cell Binding Sites in the Laminin α5-Chain G Domain, Experimental Cell Research, Vol.277, No.1, 95-106, 2002. ... Akira Otaka, Miki Nakamura, Daisuke Nameki, Eiichi Kodama, Susumu Uchiyama, Syota Nakamura, Hiroaki Nakano, Hirokazu Tamamura, Yuji Kobayashi, Masao Matsuoka and Nobutaka Fujii : Remodeling of gp41-C34 Peptide Leads to Highly Effective Inhibitors of the Fusion of HIV-1 with Target Cells, Angewandte Chemie International Edition, Vol.41, No.16, 2937-2940, 2002. ... Akira Otaka, Fumihiko Katagiri, Takayoshi Kinoshita, Yoshihiko Odagaki, Shinya Oishi, Hirokazu Tamamura, Nobuyuki Hamanaka and Nobutaka Fujii : Regio- and Stereoselective Synthesis of (E)-Alkene trans-Xaa-Pro Dipeptide Mimetics Utilizing Organocopper-Mediated Anti-SN2' Reactions, The Journal of Organic Chemistry, Vol.67, No.17, 6152-6161, 2002. ... Shinya Oishi, Takae Kamano, Ayumu Niida, Yoshihiko Odagaki, Nobuyuki Hamanaka, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Diastereoselective Synthesis of New Ψ [(E)-CH=CMe]- and Ψ [(Z)-CH=CMe]-type Alkene Dipeptide Isosteres by Organocopper Reagents and Application to Conformationally Restricted Cyclic RGD Peptidomimetics, The Journal of Organic Chemistry, Vol.67, No.17, 6162-6173, 2002. ... K Nemoto, Hirokazu Tamamura, S Mizokami, Shinya Oishi, Akira Otaka and Nobutaka Fujii : Acid-catalyzed Ring-opening Reactions of β-Aziridinyl-α,β-enoates and Their Application, Peptide Science 2002, (巻), (号), 139-142, 2003. ... Hirokazu Tamamura, Terukazu Kato, Tadakazu Hori, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of Peptidomimetics with Hydroxyethylamine Diepetide Isosteres Utilizing Aza-Payne Rearrangement and O,N-Acyl Transfer Reactions, Peptide Science 2002, (巻), (号), 143-146, 2003. ... Akira Otaka, Miki Nakamura, Eiichi Kodama, Syota Nakamura, Hiroaki Nakano, Susumu Uchiyama, Hirokazu Tamamura, Masao Matsuoka, Yuji Kobayashi and Nobutaka Fujii : Development of Fusion-inhibiting Anti-HIV-1 Peptides Based on the Structure of Molecular Complex Involved in HIV-1-cell Fusion, Peptide Science 2002, Vol.2002, No.0, 65-68, 2003. ... Kenichi Hiramatsu, Hirokazu Tamamura, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Synthesis of CXCR4 Antagonists,T140 Derivatives with Improved Biostability, and Their SAR Study, Peptide Science 2002, Vol.2002, No.0, 213-216, 2003. ... Akira Otaka, Yoshikazu Sasaki, Fumihiko Katagiri, Shinya Oishi, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of(E)-Alkene trans-Xaa-Pro Mimetics Using Organocopper Reagents, Peptide Science 2002, Vol.2002, No.0, 357-360, 2003. ... Hirokazu Tamamura, Yasuhiro Koh, Satoshi Ueda, Yoshikazu Sasaki, Tomonori Yamasaki, Manabu Aoki, Kenji Maeda, Yoriko Watai, Hisashi Arikuni, Akira Otaka, Hiroaki Mitsuya and Nobutaka Fujii : Reduction of Peptide Character of HIV Protease Inhibitors That Exhibit Nanomolar Potency against Multidrug Resistant HIV-1 Strains, Journal of Medicinal Chemistry, Vol.46, No.9, 1764-1768, 2003. ... Hirokazu Tamamura, Terukazu Kato, Akira Otaka and Nobutaka Fujii : Synthesis of potent beta-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies, Organic & Biomolecular Chemistry, Vol.1, No.14, 2468-2473, 2003. ... Nobutaka Fujii, Shinya Oishi, Kenichi Hiramatsu, Takanobu Araki, Satoshi Ueda, Hirokazu Tamamura, Akira Otaka, Shuichi Kusano, Shigemi Terakubo, Hideki Nakashima, James A. Broach, John O. Trent, Zi-xuan Wang and Stephen C. Peiper : Molecular-Size Reduction of a Potent CXCR4-Chemokine Antagonist Using Orthogonal Combination of Conformation- and Sequence-Based Libraries, Angewandte Chemie International Edition, Vol.42, No.28, 3251-3253, 2003. ... Akira Otaka, Akira Yukimasa, Junko Watanabe, Yoshikazu Sasaki, Sinya Oishi, Hirokazu Tamamura and Nobutaka Fujii : Application of samarium diiodide (SmI2)-induced reduction of γ-acetoxy-α,β-enoates with α-specific kinetic electrophilic trapping for the synthesis of amino acid derivatives, Chemical Communications, (巻), No.15, 1834-1835, 2003. ... Hirokazu Tamamura, Akira Hori, Naoyuki Kanzaki, Kenichi Hiramatsu, Makiko Mizumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Fujii Nobutaka : T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer, FEBS Letters, Vol.550, No.3, 79-83, 2003. ... Hirokazu Tamamura, Kenichi Hiramatsu, Shuichi Kusano, Shigemi Terakubo, Naoki Yamamoto, John O. Trent, Zixuan Wang, Stephen C. Peiper, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives, Organic & Biomolecular Chemistry, Vol.1, No.21, 3656-3662, 2003. ... Hirokazu Tamamura, Kenichi Hiramatsu, Makiko Mizumoto, Satoshi Ueda, Shuichi Kusano, Shigemi Terakubo, Miki Akamatsu, Naoki Yamamoto, John O. Trent, Zixuan Wang, Stephen C. Peiper, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists, Organic & Biomolecular Chemistry, Vol.1, No.21, 3663-3669, 2003. ... Akira Otaka, Etsuko Mitsuyama, Junko Watanabe, Hideaki Watanabe and Nobutaka Fujii : Synthesis of fluorine-containing bioisosteres corresponding to phosphoamino acids and dipeptide units, Biopolymers, Vol.76, No.2, 140-149, (month)2004. ... Satoshi Ueda, Kenji Tomita, Akira Otaka, Hirokazu Tamamura, Yoshiaki Yano, Katsumi Matsuzaki and Nobutaka Fujii : Synthesic Studies on 7TM-GPCR (I):Lipid Bilayer Assisted Membrane Peptide Ligation, Peptide Science 2003, Vol.40, (号), 53-56, 2004. ... Takanobu Araki, Satoshi Ueda, Kenichi Hiramatsu, Shinya Oishi, Hirokazu Tamamura, Akira Otaka, Nobutaka Fujii, Shuichi Kusano, Shigemi Terakubo, Hideki Nakashima, Zixuan Wang and Stephen C. Peiper : A New Strategy for Molecular-size Reduction Bioactive Peptide, Using Two Orthogonal Libraries of Cyclic Peptided, Peptide Science 2003, (巻), (号), 207-210, 2004. ... Hirokasu Tamamura, Akira Hori, Naoyuki Kanzaki, Kenichi Hiramatsu, Makiko Mizumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : CXCR4 Antagonists Identified as Anti-Cancer Metastatic Agents, Peptide Science 2003, Vol.2003, No.0, 65-68, 2004. ... Terukazu Kato, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Development of Potent β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere, Peptide Science 2003, Vol.2003, No.0, 231-234, 2004. ... S Mizokami, Hirokazu Tamamura, Kenichi Hiramatsu, Makiko Mizumoto, Miki Akamatsu, Hideki Nakashima, Zixuan Wang, Stephen C. Peiper, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : New Leads of Low Molecular Weight CXCR4 Antagonists Based on Enhancement of the T140-based Pharmacophores, Peptide Science 2003, Vol.2003, No.0, 285-288, 2004. ... Akira Otaka, Junko Watanabe, Akira Yukimasa, Yoshikazu Sasaki, Hideaki Watanabe, Takayoshi Kinoshita, Shinya Oishi, Hirokazu Tamamura and Nobutaka Fujii : SmI2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized (Z)-Fluoroalkene-Type Dipeptide Isosteres, The Journal of Organic Chemistry, Vol.69, No.5, 1634-1645, 2004. ... Hirokazu Tamamura, Makiko Mizumoto, Kenichi Hiramatsu, Shuichi Kusano, Shigemi Terakubo, Naoki Yamamoto, John O. Trent, Zixuan Wang, Stephen C. Peiper, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides, Organic & Biomolecular Chemistry, Vol.2, No.8, 1255-1257, 2004. ... Norio Yamamoto, Rongge Yang, Yoshiyuki Yoshinaka, Shinji Amari, Tatsuya Nakano, Jindrich Cinatl, Holger Rabenau, Hans Wilhelm Doerr, Gerhard Hunsmann, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii and Naoki Yamamoto : HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus, Biochemical and Biophysical Research Communications, Vol.318, No.3, 719-725, 2004. ... Akira Otaka, Satoshi Ueda, Kenji Tomita, Yoshiaki Yano, Hirokazu Tamamura, Katsumi Matsuzaki and Nobutaka Fujii : Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation, Chemical Communications, (巻), No.15, 1722-1723, 2004. ... Taro Toyoda, Tatsuya Hayashi, Licht Miyamoto, Shin Yonemitsu, Masako Nakano, Satsuki Tanaka, Ken Ebihara, Hiroaki Masuzaki, Kiminori Hosoda, Gen Inoue, Akira Otaka, Kenji Sato, Tohru Fushiki and Kazuwa Nakao : Possible involvement of the α1 isoform of 5'AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle, American Journal of Physiology, Endocrinology and Metabolism, Vol.287, No.1, E166-173, 2004. ... Hirokazu Tamamura, Miho Fujisawa, Kenichi Hiramatsu, Makiko Mizumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent, FEBS Letters, Vol.569, No.1-3, 99-104, 2004. ... 大髙 章, 藤井 信孝, 山本 直樹 : SARS治療薬の展望, 現代医療, Vol.36, No.11, 64-51, 2004年11月. ... 西川 裕輝, 藤井 信孝, 大髙 章 : 抗SARS-CoV活性ペプチドの創製研究, Med. Chem. News, Vol.15, (号), 18-23, 2005年(0月). ... Ayumu Niida, Makiko Mizumoto, Yoshikazu Sasaki, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of Diketopiperazine Mimmetics as Promising Scaffolds for Drug Discovery Utilizing Organocopper-Mediated anti-SN2' Reaction, Peptide Science 2004, (巻), (号), 169-172, 2005. ... Daisuke Nameki, Eiichi Kodama, Mieko Ikeuchi, Naoto Mabuchi, Akira Otaka, Hirokazu Tamamura, Mutsuhito Ohno, Nobutaka Fujii and Masao Matsuoka : Mutations Conferring Resistance to Human Immunodeficiency Virus Type 1 Fusion Inhibitors Are Restricted by gp41 and Rev-Responsive Element Functions, Journal of Virology, Vol.79, No.2, 764-770, 2005. ... Hirokazu Tamamura, Kenichi Hiramatsu, Satoshi Ueda, Zixuan Wang, Shuichi Kusano, Shigemi Terakubo, John O. Trent, Stephen C. Peiper, Naoki Yamamoto, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-Type (E)-Alkene Dipeptide Isosteres and Its Application to the Synthesis and Biological Evaluation of Pseudopeptide Analogues of the CXCR4 Antagonist FC131, Journal of Medicinal Chemistry, Vol.48, No.2, 380-391, 2005. ... Hirokazu Tamamura, Kenichi Hiramatsu, Satoshi Ueda, Takanobu Araki, M Takenaga, R Igarashi, Akira Hori, Naoyuki Kanzaki, Miho Fujisawa, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases Including AIDS, Cancer and Rheumatoid Arthritis, Peptide Science 2004, Vol.2004, (号), 121-122, 2005. ... Hirokazu Tamamura, Takanobu Araki, Ai Esaka, Satoshi Ueda, Shinya Oishi, Zixuan Wang, Stephen C. Peiper, Akira Otaka and Nobutaka Fujii : Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetrapeptide-scaffolds, Peptide Science 2004, Vol.2004, (号), 509-510, 2005. ... Terukazu Kato, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere and their Structure-activity Relationship Studies, Peptide Science 2004, Vol.2004, (号), 515-516, 2005. ... Satoshi Ueda, Akira Otaka, Hirokazu Tamamura and Nobutaka Fujii : 4-(Dimethylamino)phenacyl Group: New Photoremovable Protecting Group for Amines and Carboxylic Acids, Peptide Science 2004, Vol.2004, (号), 599-602, 2005. ... Hirokazu Tamamura, Takanobu Araki, Satoshi Ueda, Zixuan Wang, Shinya Oishi, Ai Esaka, John O. Trent, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka and Nobutaka Fujii : Identification of Novel Low Molecular Weight CXCR4 Antagonists by Structural Tuning of Cyclic Tetrapeptide Scaffolds, Journal of Medicinal Chemistry, Vol.48, No.9, 3280-3289, 2005. ... Ayumu Niida, Shinya Oishi, Yoshikazu Sasaki, Makiko Mizumoto, Hirokazu Tamamura, Nobutaka Fujii and Akira Otaka : Facile access to (Z)-alkene-containing diketopiperazine mimetics utilizing organocopper-mediated anti-SN2 reactions, Tetrahedron Letters, Vol.46, No.24, 4183-4186, 2005. ... Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Development of Anti-HIV Agents Targeting Dynamic Supramolecular Mechanism: Entry and Fusion Inhibitors Based on CXCR4/CCR5 Antagonists and gp41-C34-Remodeling Peptides, Current HIV Research, Vol.3, No.4, 289-301, 2005. ... Satoshi Ueda, Mizuno Fujita, Hirokazu Tamamura, Nobutaka Fujii and Akira Otaka : Photolabile Protection for One-Pot Sequential Native Chemical Ligation, ChemBioChem, Vol.6, No.11, 1983-1986, 2005. ... 藤井 信孝, 大髙 章, 玉村 啓和 : ケミカルプロテオミックス先導型創薬基盤の革新, 細胞工学, Vol.15, No.11, 1181-1186, 2005年11月. ... Hirokazu Tamamura, Ai Esaka, Teppei Ogawa, Takanobu Araki, Satoshi Ueda, Zixuan Wang, John O. Trent, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka and Nobutaka Fuji : Structure activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds, Organic & Biomolecular Chemistry, Vol.3, No.24, 4392-4394, 2005. ... Ayumu Niida, Zixuan Wang, Kenji Tomita, Shinya Oishi, Hirokazu Tamamura, Akira Otaka, Jean-Marc Navenot, James R. Broach, Stephen C. Peiper and Nobutaka Fujii : Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity, Bioorganic & Medicinal Chemistry Letters, Vol.16, No.1, 134-137, 2006. ... Shinya Ohishi, Kazuhide Miyamoto, Ayumu Niida, Mikiko Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka, Yoshihiro Kuroda, Akira Asai and Fujii Nobutaka : Application of Tri- and Tetrasubstituted Alkene Dipeptide Mimetics to Conformational Studies of Cyclic RGD Peptides., Tetrahedron, Vol.62, No.7, 1416-1424, 2006. ... Ayumu Niida, Kenji Tomita, Makiko Mizumoto, Hiroaki Tanigaki, Tomohiro Terada, Shinya Oishi, Akira Otaka, Ken-ichi Inui and Nobutaka Fujii : Unequivocal Synthesis of (Z)-Alkene and (E)-Fluoroalkene Dipeptide Isosters to Probe Structural Requirements of Peptide Transporter PEPT1., Organic Letters, Vol.8, No.4, 613-616, 2006. ... M Nakano, T Hamada, T Hayashi, S Yonemitsu, L Miyamoto, T Toyoda, S Tanaka, H Masuzaki, K Ebihara, Y Ogawa, K Hosoda, G Inoue, Y Yoshimasa, Akira Otaka, T Fushiki and K Nakao : a2 Isoform-specific activation of 5 adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle, Metabolism: Clinical and Experimental, Vol.55, No.3, 300-308, 2006. ... Akira Otaka : Development of chemal devices for synthesis of proteins including membrane proteins, The 6th International Symposium on Peptide and Protein Materials, Gwangju, Korea, April 2006. ... T. Koide, Y. Nishikawa, S. Asada, C. M. Yamazaki, Y. Takahara, D. L. Homma, Akira Otaka, K. Ohtani, N. Wakamiya, K. Nagata and K. Kitagawa : Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteins, The Journal of Biological Chemistry, Vol.281, No.16, 11177-11185, 2006. ... Ayumu Niida, Hiroaki Tanigaki, Eriko Inokuchi, Yoshikazu Sasaki, Shinya Oishi, Hiroaki Ohno, Hirokazu Tamamura, Zixuan Wang, C Stephene Peiper, Kazuo Kitaura, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of 3,6-Disubstituted-3,6-dihydropyridin-2-ones as Potential Diketopiperazine Mimetics Using Organocopper-Mediated anti-SN2' Reactions and Their Use in the Preparation of Low-Molecule CXCR4 Antagonists., The Journal of Organic Chemistry, Vol.71, No.10, 3942-3951, 2006. ... Ayumu Niida, Makiko Mizumoto, Tetsuo Narumi, Eriko Inokuchi, Shinya Oishi, Hiroaki Ohono, Akira Otaka, Kazuo Kitaura and Fujii Nobutaka : Synthesis of (Z)-Alkene and (E)-Fluoroalkene-Containing Diketopiperazine Mimetics Utilizing Oraganocopper-Mediated Reduction-Alkylation and Diastereoselectivity Examination Using DFT Calculations., The Journal of Organic Chemistry, Vol.71, No.11, 4118-4129, 2006. ... Tesuo Narumi, Ayumu Niida, Kenji Tomita, Shinya Oishi, Akira Otaka, Hiroaki Ohono and Nobutaka Fujii : A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres., Chemical Communications, (巻), No.45, 4720-4722, 2006. ... 大髙 章, 藤井 信孝 : 膜融合阻害性抗ウイルスペプチドの開発, 化学工業, Vol.57, No.10, 797-801, 2006年10月. ... 藤井 信孝, 大石 真也, 大髙 章 : プロテオミクスを基盤とするケミカルバイオロジー -情報から制御へ, Bionics, Vol.3, No.10, 46-51, 2006年10月. ... 大髙 章 : 新しい薬をどう創るか, --- 創薬研究の最前線 ---, 株式会社 講談社, 東京, 2007年4月. ... Akira Otaka : Amide bond cleavage for the preparation of functional peptides, Roche Colorado Corporation Peptide Symposium, Colorado, USA, Colorado, Sep. 2007. ... Ujike Makoto, Nishikawa Hiroki, Akira Otaka, Yamamoto Naoki, Yamamoto Norio, Matsuoka Masao, Kodama Eiichi, Fujii Nobutaka and Taguchi Fumihiro : Heptad Repeat-Derived Peptides Block Protease-Mediated Direct Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus but Not Entry via the Endosomal Pathway, Journal of Virology, Vol.82, No.1, 588-592, 2008. ... 大石 真也, 鳴海 哲夫, 大野 浩章, 大髙 章, 藤井 信孝 : アルケン型ジペプチドイソスターの合成法の開発と生理活性ペプチドの構造活性相関研究への応用, 有機合成化学協会誌, Vol.66, No.9, 846-857, 2008年9月. ... H. Nishikawa, S. Oishi, M. Fujita, K. Watanabe, R. Tokiwa, H. Ohno, E. Kodama, K. Izumi, K. Kajiwara, T. Naitoh, M. Matsuoka, Akira Otaka and N. Fujii : Identification of minimal sequence for HIV-1 fusion inhibitors, Bioorganic & Medicinal Chemistry, Vol.16, No.20, 9184-9187, 2008. ... H Nishikawa, S Nakamura, E Kodama, S Ito, K Kajiwara, K Izumi, Y Sakagami, S Oishi, T Ohkubo, Y Kobayashi, Akira Otaka, N Fujii and M Matsuoka : Electrostatically constrained alpha-helical peptide inhibits replication of HIV-1 resistant to Enfuvirtide, The International Journal of Biochemistry & Cell Biology, Vol.41, No.4, 891-899, 2009. ... S.-M Yun, T Moulaei, D Lim, J.K Bang, J.-E Park, S.R Shenoy, F Liu, Y.H Kang, C Liao, N.-K Soung, S Lee, D.-Y Yoon, Y Lim, D.-H Lee, Akira Otaka, E Appella, J.B McMahon, M.C Nicklaus, T.R.Jr. Burke, M.B Yaffe, A Wlodawer and K.S Lee : Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1, Nature Structural & Molecular Biology, Vol.16, No.8, 876-882, 2009. ... Kohei Sato, Shugo Tsuda, Kohei Tsuji, Ken Sakamoto, Akira Shigenaga and Akira Otaka : N-Sulfanylethylanilide derivative as a peptide thioester equivalent, Proceedings of the Twenty-Second American Peptide Symposium, (巻), (号), 72-73, 2011. ... 大髙 章 : 標的タンパク質捕捉の科学, 徳島大学大学院ヘルスバイオサイエンス研究部第8回公開シンポジウム, (巻), (号), (頁), 2011年11月. ... Akira Otaka : N-Sulfanylethylanilides as a Versatile Chemical Device for Protein Chemistry, 2012 SNU Symposium on Medicinal Chemistry, (巻), (号), (頁), Seoul, May 2012. ... 大髙 章 : 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦, 第101回有機合成シンポジウム2012年【春】, (巻), (号), (頁), 2012年6月. ... 大髙 章 : 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦, アステラス製薬シンポジウム, (巻), (号), (頁), 2012年8月. ... Akira Otaka : Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptide, The 14th Akabori Conference, (巻), (号), (頁), Niseko, Japan, Sep. 2012. ... 大髙 章 : 生体有機化学 第12章 生理活性ペプチドホルモン, 株式会社 東京化学同人, (都市), 2012年10月. ... 大髙 章 : 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦, 有機合成化学協会誌, Vol.70, No.10, 1054, 2012年10月. ... Akira Otaka : Development of "Tracable Linkerfor" Protein Idebtification Using Stimulus-responsive Amino Acid, The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, (巻), (号), (頁), Kyoto, Oct. 2012. ... 大髙 章 : 標的タンパク質同定に向けたトレーサブルリンカーの開発, 新学術領域研究「天然物ケミカルバイオロジー∼分子標的と活性制御∼」第4回公開シンポジウム, 2013年5月. ... 大髙 章 : ペプチド・タンパク質を基盤とする創薬展開への化学基盤の開拓, 創薬懇話会2013, 2013年7月. ... 大髙 章 : 自然に学ぶペプチド化学, 第45回若手ペプチド夏の勉強会, (巻), (号), (頁), 2013年7月. ... 佐藤 浩平, 大髙 章 : ペプチド・タンパク質を基盤とする創薬展開への化学基盤の開拓, 化学工業, Vol.65, No.6, 411-417, 2014年6月. ... 大髙 章 : 薬学教育の現状と期待(創薬研究から), 日本学術会議日本薬学会共催シンポジウム「薬学教育への期待:4年制薬学教育のあり方と参照基準の作成に向けて」, (巻), (号), (頁), 2014年8月. ... 中村 太寛, 佐藤 浩平, 大髙 章 : タンパク性医薬品開発に向けたペプチド化学, 化学工業(特集 ペプチド化学の新潮流(1)), Vol.65, No.11, 842-848, 2014年11月. ... Masahiro Furutani, Akihito Uemura, Akira Shigenaga, Chiaki Komiya, Akira Otaka and Kazunori Matsuura : Inside Back Cover: A photoinduced growth system of peptide nanofibres addressed by DNA hybridization, Chemical Communications, Vol.51, No.38, 8197, 2015. ... Koji Takagi, Hayato Fukuda, Satoshi Syuto, Akira Otaka and Mitsuhiro Arisawa : Safe removal of the allyl protecting groups of allyl esters using a recyclable, low-leaching and ligand-free palladium nanoparticle Catalyst, Advanced Synthesis & Catalysis, Vol.357, No.9, 2119-2124, 2015. ... Chiharu Mizuguchi, Fuka Ogata, Shiho Mikawa, Kohei Tsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito : Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes, The Journal of Biological Chemistry, Vol.290, No.34, 20947-20959, 2015. ... Akira Otaka : N-Sulfanylethylanilide peptide as a crypto thioester for protein chemical synthesis, 5th Modern Solid Phase Peptide Synthesis & Its Application Symposium, Queensland (Australia), Oct. 2015. ... Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga, Miki Imanishi, Shiro Futaki and Akira Otaka : Preparation of peptide thioesters from naturally occurring sequences using reaction sequence consisting of regioselective S-cyanylation and hydrazinolysis, Biopolymers, Vol.106, No.4, 531-546, 2015. ... 宮島 凜, 津田 雄介, 猪熊 翼, 重永 章, 大髙 章 : Preparation of peptide thioesters from naturally occuring sequences using a chemical protocol, 第52回ペプチド討論会, 2015年11月. ... 小宮 千明, 粟飯原 圭佑, 猪熊 翼, 重永 章, 大髙 章 : Development of intein-inspired peptide bond processing device, 第52回ペプチド討論会, 2015年11月. ... 大髙 章 : 創薬人育成教育から見えてきた薬学教育の将来について-薬の顔相学-, 第25回医療薬学会年会「教育セミナー」, 2015年11月. ... 高橋 伶奈, 種子島 幸祐, 辻 耕平, 重永 章, 大髙 章, 原 孝彦 : ケモカインCXCL14は癌細胞のヘパラン硫酸に高親和性で結合する, 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会, (巻), (号), (頁), 2015年12月. ... Keisuke Aihara, Kosuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : One-pot/sequential native chemical ligation using photo-caged crypto-thioester, Organic Letters, Vol.18, No.3, 596-599, 2016. ... Chiaki Komiya, Keisuke Aihara, Kou Morishita, Hao Ding, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Development of an intein-inspired amide cleavage chemical device, The Journal of Organic Chemistry, Vol.81, No.2, 699-707, 2016. ... Hirokazu Kariyazono, Ryo Nadai, Rin Miyajima, Yuki Haraya, Teruhiko Baba, Akira Shigenaga, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito : Formation of stable nanodiscs by bihelical apolipoprotein A-I mimetic peptide, Journal of Peptide Science, Vol.22, No.2, 116-122, 2016. ... Tatsuhiko Shimizu, Rin Miyajima, Kohei Sato, Ken Sakamoto, Naoto Naruse, Miku Kita, Akira Shigenaga and Akira Otaka : Facile synthesis of C-terminal peptide thioacids under mild conditions from N-sulfanylethylanilide peptides, Tetrahedron, Vol.72, 992-998, 2016. ... Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka and Takayoshi Suzuki : Identification of SNAIL1 Peptide-Based Irreversible Lysine Specific Demethylase 1-Selective Inactivators, Journal of Medicinal Chemistry, Vol.59, No.4, 1531-1544, 2016. ... Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Development of intein-inspired peptide bond processing device, Peptide Science 2015, (巻), (号), 281-282, 2016. ... Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Preparation of peptide thioesters from naturally occuring sequences using a chemical protocol, Peptide Science 2015, (巻), (号), 21-22, 2016. ... Yuki Haraya, Ryo Nadai, Hitoshi Kimura, Kazuchika Nishitsuji, Kenji Uchimura, Kumiko Sakai-Kato, Kohsaku Kawakami, Akira Shigenaga, Toru Kawakami, Akira Otaka, Hironobu Hojo, Naomi Sakashita and Hiroyuki Saito : Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides, Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.1858, No.6, 1339-1349, 2016. ... 山岡 浩輔, 粟飯原 圭佑, 成瀬 公人, 猪熊 翼, 重永 章, 大髙 章 : 光応答型チオエステル等価体を用いたOne-potタンパク質化学合成法の開発, 日本薬学会第136年会, (巻), (号), (頁), 2016年3月. ... 成瀬 公人, 佐藤 浩平, 中村 太寛, 猪熊 翼, 重永 章, 大髙 章 : マンノース六リン酸修飾型GM2活性化タンパク質の合成研究, 日本薬学会第136年会, (巻), (号), (頁), 2016年3月. ... 森崎 巧也, 傳田 将也, 中村 太寛, 辻 大輔, 山本 純, 猪熊 翼, 伊藤 孝司, 重永 章, 大髙 章 : 標的タンパク質の高効率的同定を可能とする新規リンカー分子の開発研究, 日本薬学会第136年会, 2016年3月. ... 江藤 三弘, 森本 恭平, 辻 耕平, 猪熊 翼, 重永 章, 大髙 章 : チオエステル等価体としてのN-sulfanylethylcoumarinylamide (SECmide) の開発及びペプチド合成への応用, 日本薬学会第136年会, (巻), (号), (頁), 2016年3月. ... 寺中 孝久, 粟飯原 圭佑, 江藤 三弘, 猪熊 翼, 重永 章, 大髙 章 : 環状ペプチドTrichamideの合成研究, 日本薬学会第136年会, (巻), (号), (頁), 2016年3月. ... 重永 章, 大髙 章 : ペプチド化学を基盤としたケミカルバイオロジー研究のための基盤技術の開拓, 日本薬学会第136年会, (巻), (号), (頁), 2016年3月. ... Tatsuhiko Shimizu, Rin Miyajima, Naoto Naruse, Kosuke Yamaoka, Keisuke Aihara, Akira Shigenaga and Akira Otaka : Facile preparation of peptides with C-terminal N-alkylamide via radical-initiated dethiocarboxylation, Chemical & Pharmaceutical Bulletin, Vol.64, No.4, 375-378, 2016. ... 灘井 亮, 武知 佑樹, 西辻 和親, 内村 健治, 加藤 くみ子, 重永 章, 川上 徹, 大髙 章, 北條 裕信, 坂下 直実, 斎藤 博幸 : アルギニンペプチドの細胞膜透過はグリコサミノグリカン糖鎖へのエンタルピー依存的結合によって促進される, 日本膜学会第38年会, (巻), (号), (頁), 2016年5月. ... Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Kohei Tsuji, Akira Shigenaga, Akira Otaka and Takahiko Hara : A CXC type chemokine CXCL14 directly binds to CpG-C DNA to activate Toll-like receptor 9 signaling, Nucleic Acid Sensing Pathways: Innate Immunity, Immunobiology and Therapeutics (E2), (巻), (号), (頁), Dresden, May 2016. ... Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Kouji Itou, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : An N-Sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins, Chemical Communications, Vol.52, 6911-6913, 2016. ... Akira Otaka, Rin Miyajima, Yusuke Tsuda and Akira Shigenaga : Regioselective S-Cyanylation-mediated Preparation of Peptide Thioester, 16th Akabori Conference Japanese-German Symposium on Peptide Science, Kobe, May 2016. ... 松浦 和則, 植村 明仁, 中原 正彦, 古谷 昌大, 重永 章, 小宮 千明, 大髙 章 : 光誘起ペプチドナノファイバー成長の時空間制御, 第65回高分子学会年次学会, (巻), (号), (頁), 2016年5月. ... Masaya Denda, Takuya Morisaki, Taiki Kohiki, Jun Yamamoto, Kohei Sato, Ikuko Sagawa, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka : Labelling of endogenous target protein via N-S acyl transfer-mediated activation of N-sulfanylethylanilide, Organic & Biomolecular Chemistry, Vol.14, 6244-6251, 2016. ... 津田 雄介, 重永 章, 佐藤 浩平, 中村 太寛, 北風 圭介, 猪熊 翼, 伊藤 孝司, 大髙 章 : 天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発, ケミカルバイオロジー, Vol.9, 7-10, 2016年6月. ... 森崎 巧也, 傳田 将也, 辻 大輔, 山本 純, 猪熊 翼, 伊藤 孝司, 重永 章, 大髙 章 : 標的タンパク質精製ツール"SEAlide-based traceable linker"の開発, 日本ケミカルバイオロジー学会第11回年会, 2016年6月. ... 古曳 泰規, 傳田 将也, 森崎 巧也, 辻 大輔, 猪熊 翼, 伊藤 孝司, 重永 章, 大髙 章 : ''SEAL-tag''を基盤とした細胞内での標的タンパク質ラベル化法の開発, 日本ケミカルバイオロジー学会第11回年会, 2016年6月. ... 寺中 孝久, 粟飯原 圭佑, 重永 章, 猪熊 翼, 大髙 章 : 中分子創薬を指向した環状ペプチドTrichamideの合成研究, 創薬懇話会2016 in 蓼科, (巻), (号), (頁), 2016年6月. ... 山岡 浩輔, 粟飯原 圭佑, 成瀬 公人, 猪熊 翼, 重永 章, 大髙 章 : 光応答型チオエステル等価体を用いた多成分One-pot NCL法の開発研究, 創薬懇話会2016 in 蓼科, (巻), (号), (頁), 2016年6月. ... Takahiro Nakamura, Kohei Sato, Naoto Naruse, Keisuke Kitakaze, Tsubasa Inokuma, Takatsugu Hirokawa, Akira Shigenaga, Kouji Itou and Akira Otaka : Tailored synthesis of 162-residue S-monoglycosylated GM2-activator protein (GM2AP) analogues that allows access to protein library, ChemBioChem, Vol.17, No.20, 1986-1992, 2016. ... Takahiro Nakamura, Kohei Sato, Naoto Naruse, Keisuke Kitakaze, Tsubasa Inokuma, Takatsugu Hirokawa, Akira Shigenaga, Kouji Itou and Akira Otaka : Back Cover: Tailored synthesis of 162-residue S-monoglycosylated GM2-activator protein (GM2AP) analogues that allows access to protein library, ChemBioChem, Vol.17, No.20, 1994, 2016. ... 松浦 和則, 植村 明仁, 稲葉 央, 古曳 泰規, 重永 章, 大髙 章 : 光誘起ペプチド繊維成長による走光性リポソームの創製, 第26回バイオ・高分子シンポジウム, (巻), (号), (頁), 2016年7月. ... 成瀬 公人, 佐藤 浩平, 中村 太寛, 猪熊 翼, 重永 章, 大髙 章 : リソソーム移行型GM2活性化タンパク質の合成研究, 第48回若手ペプチド夏の勉強会, 2016年8月. ... 寺中 孝久, 粟飯原 圭佑, 重永 章, 猪熊 翼, 大髙 章 : Cys-free ligationを用いた環状ペプチドTrichamideの合成研究, 第48回若手ペプチド夏の勉強会, (巻), (号), (頁), 2016年8月. ... Mitsuhiro Eto, Naoto Naruse, Kyohei Morimoto, Kosuke Yamaoka, Kohei Sato, Kohei Tsuji, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Development of an anilide-type scaffold for the thioester precursor N-sulfanylethylcoumarinyl amide, Organic Letters, Vol.18, No.17, 4416-4419, 2016. ... 水口 智晴, 三河 志穂, 馬場 照彦, 島内 寿徳, 重永 章, 奥平 桂一郎, 大髙 章, 斎藤 博幸 : Iowa変異型アポA-Iによる脂質膜環境下でのアミロイド線維形成, 第4回日本アミロイド―シス研究会学術集会, 2016年8月. ... Keisuke Aihara, Kohsuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : One-pot/sequential native chemical ligation using photo-responsive crypto-thioester, EPS Proceedings 2016, (巻), (号), 39, 2016. ... Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma, Kouji Itou and Akira Otaka : Second-generation synthetic strategy of GM2-activator protein (GM2AP) analogues applicable to the preparation of a protein library, EPS Proceedings 2016, (巻), (号), 63, 2016. ... Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Intein-inspired amide bond processing device, EPS Proceedings 2016, (巻), (号), 60, 2016. ... Keisuke Aihara, Kosuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : One-Pot/Sequential Native Chemical Ligation Using Photo-responsive Crypto-thioester, 34th European Peptide Symposium 2016 & 8th International Peptide Symposium, Leipzig, Germany, Sep. 2016. ... Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Intein-inspired Amide Bond Processing Device, 34th European Peptide Symposium 2016 & 8th International Peptide Symposium, (巻), (号), (頁), Leipzig, Germany, Sep. 2016. ... Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma, Kouji Itou and Akira Otaka : Second-Generation Synthetic Strategy of GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library, 34th European Peptide Symposium 2016 & 8th International Peptide Symposium, Leipzig, Germany, Sep. 2016. ... Shiho Mikawa, Chiharu Mizuguchi, Kazuchika Nishitsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Naomi Sakashita, Akira Otaka, Kenichi Akaji and Hiroyuki Saito : Heparin promotes fibril formation of the N-terminal fragment of amyloidogenic aplipoprotein A-I, FEBS Letters, Vol.590, 3492-3500, 2016. ... 重永 章 : N-Sアシル基転移反応を基盤としたタンパク質完全化学合成法の開拓, 有機合成化学協会中国四国支部主催第74回パネル討論会『次世代を切り拓く全合成研究の若い力』, (巻), (号), (頁), 2016年10月. ... 桑原 智希, 水野 彰, 福田 隼, 渡邉 瑞貴, 神田 敦宏, 石田 晋, 大髙 章, 周東 智 : Design and synthesis of the spiro-cyclopropane scaffold peptidomimetics minicking both alpha-helix and beta-strand, 第53回ペプチド討論会, (巻), (号), (頁), 2016年10月. ... 粟飯原 圭佑, 吉丸 哲郎, 小松 正人, 重永 章, 片桐 豊雅, 大髙 章 : Development of stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells, 第53回ペプチド討論会, (巻), (号), (頁), 2016年10月. ... 中村 太寛, 重永 章, 成瀬 公人, 猪熊 翼, 大髙 章 : Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library, 第53回ペプチド討論会, (巻), (号), (頁), 2016年10月. ... 寺中 孝久, 粟飯原 圭佑, 山岡 浩輔, 猪熊 翼, 重永 章, 大髙 章 : Synthetic study of trichamide using Cys-free ligation, 第53回ペプチド討論会, (巻), (号), (頁), 2016年10月. ... 森崎 巧也, 傳田 将也, 山本 純, 辻 大輔, 猪熊 翼, 伊藤 孝司, 重永 章, 大髙 章 : Development of N-sulfanylethylanilide (SEAlide)-based traceable linker for enrichment and selective labeling of target proteins, 第53回ペプチド討論会, 2016年10月. ... 山岡 浩輔, 粟飯原 圭佑, 成瀬 公人, 猪熊 翼, 重永 章, 大髙 章 : One-pot sequential native chemical ligations using photocaged crypto-thioester, 第53回ペプチド討論会, (巻), (号), (頁), 2016年10月. ... 伊藤 幸裕, 粟飯原 圭佑, Paolo Mellini, 東條 敏史, 太田 庸介, 津元 裕樹, Viswas Raja Solomon, Peng Zhan, 鈴木 美紀, 小笠原 大介, 重永 章, 猪熊 翼, 中川 秀彦, 宮田 直樹, 水上 民夫, 大髙 章, 鈴木 孝禎 : Design, synthesis and biological evaluation of SNAIL1 peptide-based lysine specific demethylase 1 inhibitors, 第53回ペプチド討論会, (巻), (号), (頁), 2016年10月. ... 三河 志穂, 水口 智晴, 森田 いずみ, 大山 浩之, 馬場 照彦, 重永 章, 島内 寿徳, 小林 典裕, 大髙 章, 斎藤 博幸 : Effect of heparin on amyloid fibril formation of apoA-I fragment peptides, 第53回ペプチド討論会, (巻), (号), (頁), 2016年10月. ... 灘井 亮, 原矢 佑樹, 西辻 和親, 内村 健治, 加藤 くみ子, 重永 章, 川上 徹, 大髙 章, 大髙 章, 北條 裕信, 坂下 直実, 斎藤 博幸 : Sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides via enthalpy-driven interactions, 第53回ペプチド討論会, (巻), (号), (頁), 2016年10月. ... Shugo Tsuda, Masayoshi Mochizuki, Ken Sakamoto, Masaya Denda, Hideki Nishio, Akira Otaka and Taku Yoshiya : N-Sulfanylethylaminooxybutyramide (SEAoxy): A Crypto-Thioester Compatible with Fmoc Solid-Phase Peptide Synthesis, Organic Letters, Vol.18, No.22, 5940-5943, 2016. ... 粟飯原 圭佑, 寺中 孝久, 山岡 浩輔, 猪熊 翼, 重永 章, 大髙 章 : ケミカルバイオロジー研究を指向した環状ペプチドtrichamideの合成研究, 第55回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, (巻), (号), (頁), 2016年11月. ... 成瀬 公人, 佐藤 浩平, 中村 太寛, 猪熊 翼, 重永 章, 大髙 章 : マンノース6リン酸修飾型GM2活性化タンパク質の合成研究, 第55回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, (巻), (号), (頁), 2016年11月. ... 西田 航大, 猪熊 翼, 重永 章, 大髙 章 : 非天然アミノ酸含有ペプチドの新規効率的合成法の開発, 第55回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, (巻), (号), (頁), 2016年11月. ... 成瀬 公人, 江藤 三弘, 猪熊 翼, 重永 章, 大髙 章 : N-Sulfanylethylcoumarinylamide (SECmide) を利用したN-Sアシル転移促進剤の探 索とペプチド合成への応用, 第42回反応と合成の進歩シンポジウム, (巻), (号), (頁), 2016年11月. ... 水口 智晴, 三河 志穂, 馬場 照彦, 島内 寿徳, 重永 章, 奥平 桂一郎, 大髙 章, 斎藤 博幸 : アミロイドーシス変異アポA-I Iowaの脂質膜結合状態の解析, 膜シンポジウム2016, 2016年12月. ... 伊藤 幸裕, 粟飯原 圭佑, Paolo Mellini, 東條 敏史, 太田 庸介, 津元 裕樹, Viswas Raja Solomon, Peng Zhan, 鈴木 美紀, 小笠原 大介, 重永 章, 猪熊 翼, 中川 秀彦, 宮田 直樹, 水上 民夫, 大髙 章, 鈴木 孝禎 : ヒドラジン構造を持つペプチド性LSD1阻害薬の創製, 第34回メディシナルケミストリーシンポジウム, (巻), (号), (頁), 2016年12月. ... 森崎 巧也, 傳田 将也, 辻 大輔, 山本 純, 猪熊 翼, 伊藤 孝司, 重永 章, 大髙 章 : SEAlideを基盤とした標的タンパク質精製ツールの開発研究, 第34回メディシナルケミストリーシンポジウム, 2016年12月. ... 成瀬 公人, 種子島 幸祐, 辻 耕平, 猪熊 翼, 重永 章, 原 孝彦, 大髙 章 : N-Sulfanylethylanilideペプチドを利用したケモカイン誘導体の合成とToll-like receptor 9の活性化への影響について, 第34回メディシナルケミストリーシンポジウム, (巻), (号), (頁), 2016年12月. ... 津田 雄介, 重永 章, 辻 耕平, 傳田 将也, 佐藤 浩平, 北風 圭介, 中村 太寛, 猪熊 翼, 伊藤 孝司, 大髙 章 : タンパク質位置選択的修飾を指向したチオエステル調製法の開発, 第34回メディシナルケミストリーシンポジウム, 2016年12月. ... 種子島 幸祐, 高橋 伶奈, 塗谷 秀子, 成瀬 公人, 辻 耕平, 重永 章, 大髙 章, 原 孝彦 : CXCケモカインCXCL14はCpG DNAに結合し，Toll-like receptor 9シグナルを活性化する, 第39回日本分子生物学会年会, (巻), (号), (頁), 2016年12月. ... Takahiko Hara, Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Naoto Naruse, Kohei Tsuji, Akira Shigenaga and Akira Otaka : A Novel Function of a CXC-type Chemokine CXCL14 as a Specific Carrier of CpG DNA into Dendritic Cells for Activating Toll-like Receptor 9-mediated Adaptive Immunity, 58th ASH Annual Meeting & Exposition, (巻), (号), (頁), San Diego, Dec. 2016. ... Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma and Akira Otaka : Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library, Peptide Science 2016, (巻), (号), 75-76, 2017. ... Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka : Development of N-sulfanyltehylanilide (SEAlide)-based traceable linker for enrichment and selective labeling of target proteins, Peptide Science 2016, (巻), (号), 179-181, 2017. ... Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : One-pot sequential native chemical ligations using photocaged crypto-thioester, Peptide Science 2016, (巻), (号), 73-74, 2017. ... Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka and Takayoshi Suzuki : Design, synthesis and biological evaluation of SNAIL1 peptide-based lysine specific demethylase 1 inhibitors, Peptide Science 2016, (巻), (号), 165-166, 2017. ... Shiho Mikawa, Chiharu Mizuguchi, Izumi Morita, Hiroyuki Oyama, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Norihiro Kobayashi, Akira Otaka, Kenichi Akaji and Hiroyuki Saito : Effect of heparin on amyloid fibril formation of apoA-I fragment peptides, Peptide Science 2016, (巻), (号), 149-151, 2017. ... Ryo Nadai, Yuki Haraya, Kazuchika Nishitsuji, Kenji Uchimura, Kumiko Sakai-Kato, Akira Shigenaga, Toru Kawakami, Akira Otaka, Hironobu Hojo, Naomi Sakashita and Hiroyuki Saito : Sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides via enthalpy-driven interactions, Peptide Science 2016, (巻), (号), 141-142, 2017. ... Tsubasa Inokuma, Takahisa Jichu, Kodai Nishida, Akira Shigenaga and Akira Otaka : A convenient method for preparation of -imino carboxylic acid derivatives and application to the asymmetric synthesis of unnatural -amino acid derivative, Chemical & Pharmaceutical Bulletin, Vol.65, No.6, 573-581, 2017. ... Akiko Yano, Yuko Takahashi, Hiromi Moriguchi, Tomoaki Inazumi, Tomoaki Koga, Akira Otaka, Yukihiko Sugimoto and Hironobu Hojo : An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of Gas, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1862, No.6, 615-622, 2017. ... 成瀬 公人, 津田 修吾, 大川内 健人, 猪熊 翼, 重永 章, 大髙 章 : 効率的タンパク質合成のためのSEAlideペプチドを用いたon-resinチオエステル化法の開発, 日本薬学会第137年会, (巻), (号), (頁), 2017年3月. ... 森本 恭平, 山次 建三, 粟飯原 圭佑, 猪熊 翼, 重永 章, 金井 求, 大髙 章 : DMAP誘導体を用いた環状ペプチド合成法の開発, 日本薬学会第137年会, (巻), (号), (頁), 2017年3月. ... 古曳 泰規, 傳田 将也, 藤川 昴樹, 猪熊 翼, 重永 章, 小暮 健太朗, 大髙 章 : N-Sulfanylethylanilideを用いた細胞内標的タンパク質ラベル化法の開発, 日本薬学会第137年会, 2017年3月. ... 河野 誉良, 成瀬 公人, 猪熊 翼, 重永 章, 大髙 章 : チオエステル等価体として機能するタンパク質の化学合成のための新規補助基の開発, 日本薬学会第137年会, (巻), (号), (頁), 2017年3月. ... 西田 航大, 寺中 孝久, 猪熊 翼, 重永 章, 大髙 章 : MnO2を用いたα-イミノカルボン酸誘導体の効率的合成法の開発, 日本薬学会第137年会, (巻), (号), (頁), 2017年3月. ... 灘井 亮, 原矢 佑樹, 西辻 和親, 内村 健治, 加藤 くみ子, 重永 章, 川上 徹, 大髙 章, 北條 裕信, 坂下 直実, 斎藤 博幸 : アルギニンペプチドのグリコサミノグリカン糖鎖を介した細胞膜透過機構に関する物理化学的解析, 日本薬学会第137年会, (巻), (号), (頁), 2017年3月. ... Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka : Elucidation of inhibitor-binding pocket of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology, Organic & Biomolecular Chemistry, Vol.15, No.25, 5289-5297, 2017. ... Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka : Inside Front Cover: Elucidation of inhibitor-binding pocket of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology, Organic & Biomolecular Chemistry, Vol.15, (号), 5240, 2017. ... 川原 遥華, 奥平 桂一郎, 宮下 直樹, 津田 雄介, 森本 恭平, 辻 耕平, 重永 章, 大髙 章, 石田 竜弘 : 光応答性アポリポタンパク質の開発, 日本薬剤学会第32年会, 2017年5月. ... Akira Otaka, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga and Toyomasa Katagiri : Development of long-lasting stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells, The 6th Pharmaceutical Sciences World Congress 2017, (巻), (号), (頁), Stockholm, May 2017. ... Keisuke Aihara, Tsubasa Inokuma, Takahisa Jichu, Zhenjian Lin, Feixue Fu, Kosuke Yamaoka, Akira Shigenaga, David A. Hutchins, Eric W. Schmidt and Akira Otaka : Cysteine-free intramolecular ligaiton of N-sulfanylethylanilide peptide using 4-mercaptobenzylphosphonic acid: Synthesis of cyclic peptide, trichamide, Synlett, Vol.28, No.15, 1944-1949, 2017. ... Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Development of methodology for preparation of peptide thioester via on-resin N-S acyl transfer using N-sulfanylethylanilide peptide, American Peptide Symposium 2017, (巻), (号), (頁), Whistler, BC, Canada, June 2017. ... Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka : Development of N-Sulfanylethylanilide-based Traceable Linker for Purification and Selective Labeling of Target Proteins, American Peptide Symposium 2017, Whistler, BC, Canada, June 2017. ... Akira Otaka : Application of N-Sulfanylethylanilide(SEAlide) Unit to Protein Chemical Synthesis and Protein Enrichment, American Peptide Symposium 2017, (巻), (号), (頁), Whistler, BC, Canada, June 2017. ... 河野 誉良, 成瀬 公人, 猪熊 翼, 重永 章, 大髙 章 : タンパク質化学合成のための新規N-ペプチジルアニリド型補助基の開発, 創薬懇話会2017 in 加賀, (巻), (号), (頁), 2017年7月. ... 西田 航大, 猪熊 翼, 重永 章, 大髙 章 : ペプチド創薬を指向した非天然アミノ酸含有ペプチドの新規効率的合成法の開発, 創薬懇話会2017 in 加賀, (巻), (号), (頁), 2017年7月. ... Akira Otaka : Development of anti-breast cancer stapled peptides targeting BIG3-PHB2 interaction, AIMECS 2017, (巻), (号), (頁), Melbourne, Australia, July 2017. ... 河野 誉良, 成瀬 公人, 猪熊 翼, 重永 章, 大髙 章 : N-Sアシル基転移反応の速度差を利用したライゲーション反応のための新規補助基の開発, 第49回若手ペプチド夏の勉強会, (巻), (号), (頁), 2017年8月. ... 西田 航大, 猪熊 翼, 重永 章, 大髙 章 : ペプチドへの直接的不斉反応を基盤とする非天然アミノ酸含有ペプチドの新規効率的合成法の開発, 第49回若手ペプチド夏の勉強会, (巻), (号), (頁), 2017年8月. ... 津田 雄介, 猪熊 翼, 重永 章, 大髙 章 : タンパク質位置選択的修飾を目指したチオエステル調製法の開発, 第49回若手ペプチド夏の勉強会, (巻), (号), (頁), 2017年8月. ... Akira Shigenaga, Jun Yamamoto, Taiki Kohiki, Tsubasa Inokuma and Akira Otaka : Invention of stimulus-responsive peptide-bond-cleaving residue (Spr) and its application to chemical biology tools, Journal of Peptide Science, Vol.23, (号), 505-513, Aug. 2017. ... 大髙 章 : 薬学基礎教育と臨床教育連携への提言-薬学における教養 化学-, 第2回日本薬学教育学会大会, (巻), (号), (頁), 2017年9月. ... Taiki Kohiki, Yusuke Nishikawa, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Chemical synthetic platform for chlorpromazine oligomers that were reported as photo-degradation products of chlorpromazine, Chemical & Pharmaceutical Bulletin, Vol.65, No.12, 1161-1166, 2017. ... Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Naoto Naruse, Kohei Tsuji, Akira Shigenaga, Akira Otaka and Takahiko Hara : CXCL14 acts as a specific carrier of CpG into dendritic cells and activates Toll-like receptor 9-mediated adaptive immunity, EBioMedicine, Vol.24, 247-256, 2017. ... 大髙 章, 重永 章 : 「第I編 ペプチド合成，第二章 ペプチドの液相合成」医療・診断をささえるペプチド科学―再生医療・DDS・診断への応用―(平野義明 監修), 株式会社 シーエムシー出版, (都市), 2017年10月. ... 小久保 友絵, 池田 茉莉那, 渡部 匡史, 重永 章, 大髙 章, 藤室 雅弘 : 徳島大学化合物ライブラリーを用いた抗ヘルペスウイルス化合物の探索, 第67回日本薬学会近畿支部大会, (巻), (号), (頁), 2017年10月. ... 古曳 泰規, 加藤 有介, 西川 祐輔, 頼田 和子, 佐川 幾子, 傳田 将也, 猪熊 翼, 重永 章, 福井 清, 大髙 章 : N-Sアシル基転移を基盤としたタンパク質ラベル化法を用いたD-アミノ酸酸化酵素阻害剤の結合サイト解明研究, 第56回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, (巻), (号), (頁), 2017年10月. ... 大川内 健人, 成瀬 公人, 重永 章, 大髙 章 : On-resinチオエステル化を利用した環状ペプチド合成法の開発, 第56回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, (巻), (号), (頁), 2017年10月. ... 大髙 章 : モルフィネからはじまる薬の話, 第56回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会:高校生向けランチョンセミナー, 2017年10月. ... 寺中 孝久, 粟飯原 圭佑, 山岡 浩輔, 猪熊 翼, 重永 章, 大髙 章 : チオエステル等価体ユニットを利用した環状ペプチド効率的合成法の開発, 第35回メディシナルケミストリーシンポジウム, (巻), (号), (頁), 2017年10月. ... 小宮 千明, 津田 雄介, 宮島 凜, 猪熊 翼, 重永 章, 大髙 章 : タンパク質C末端特異的活性化反応の開発, 第35回メディシナルケミストリーシンポジウム, (巻), (号), (頁), 2017年10月. ... 大髙 章 : 有機化学メジャーの薬剤師・創薬科学研究者を育成しよう, 第12回有機化学系教科担当教員会議, (巻), (号), (頁), 2017年11月. ... 重永 章 : アミド結合切断反応を基盤とした生命科学指向型ツールの開発, 第43回反応と合成の進歩シンポジウム, (巻), (号), (頁), 2017年11月. ... 小宮 千明, 月本 準, 森崎 巧也, 津田 雄介, 宮島 凜, 猪熊 翼, 重永 章, 伊藤 孝司, 大髙 章 : Development of methodology for producing thioesters from naturally occurring peptide sequence, 第54回ペプチド討論会, 2017年11月. ... 成瀬 公人, 大川内 健人, 猪熊 翼, 重永 章, 伊藤 孝司, 大髙 章 : N-S-acyl-transfer-mediated On-resin Formation of Thioester with Practical Application to Peptide Synthesis, 第54回ペプチド討論会, 2017年11月. ... 鳴海 哲夫, 大髙 章 : 第3章 第3節 ペプチドの不安定性を解決するペプチド結合の置換技術, ペプチド医薬品のスクリーニング・安定化・製剤化技術, (巻), (号), 130-140, 2017年12月. ... 大髙 章, 重永 章 : 天然に学ぶタンパク質合成化学, 有機合成化学協会誌, Vol.76, No.1, 45-54, 2018年1月. ... 大髙 章, 重永 章 : 十字路:Native Chemical Ligation法, 有機合成化学協会誌, Vol.76, No.1, 66, 2018年1月. ... Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : N-S-acyl-transfer-mediated On-resin Formation of Thioester with Practical Application to Peptide Synthesis, Peptide Science 2017, (巻), (号), 32-33, 2018. ... Chiaki Komiya, Jun Tsukimoto, Takuya Morisaki, Yusuke Tsuda, Rin Miyajima and Tsubasa Inokuma : Development of methodology for producing thioesters from naturally occurring peptide sequence, Peptide Science 2017, (巻), (号), 86-87, 2018. ... 大髙 章 : 脱不斉化ヘリックスペプチドはPPI 制御分子として機能するか?, 第1回 徳島大学統合的がん創薬研究クラスター合同ミーティング, (巻), (号), (頁), 2018年2月. ... Akira Otaka : Current Topics - Drug Discovery: Recent Progress and the Future Foreward, Chemical & Pharmaceutical Bulletin, Vol.66, No.3, 189-190, 2018. ... 大髙 章 : タンパク質加水分解酵素を利用したタンパク質C末端特異的チオエステル化反応の開発, ペプチド科学談話会2018, (巻), (号), (頁), 2018年3月. ... 重永 章 : スクリプス研究所Janda研への留学経験を振り返る, 日本薬学会第138年会(シンポジウム 若手の海外挑戦とそこから学ぶ次世代創薬研究), (巻), (号), (頁), 2018年3月. ... 重永 章, 大髙 章 : アシル基転移反応を基盤とする標的タンパク質精製・機能解明ツールの開発, 日本薬学会第138年会(シンポジウム 中分子創薬研究のフロンティア), (巻), (号), (頁), 2018年3月. ... 小宮 千明, 月本 準, 森崎 巧也, 津田 雄介, 宮島 凜, 猪熊 翼, 重永 章, 伊藤 孝司, 大髙 章 : 均一修飾タンパク質の合成を指向したタンパク質C末端特異的活性化反応の開発, 日本薬学会第138年会, 2018年3月. ... Chiharu Mizuguchi, Mitsuki Nakamura, Naoko Kurimitsu, Takashi Ohgita, Kazuchika Nishitsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito : Effect of phosphatidylserine and cholesterol on membrane-mediated fibril formation by the N-terminal amyloidogenic fragment of apolipoprotein A-I, Scientific Reports, Vol.8, No.1, Articlenumber-5497, 2018. ... Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Resin-bound crypto-thioester for native chemical ligation, Organic Letters, Vol.20, No.8, 2449-2453, 2018. ... Hiroshi Inaba, Akihito Uemura, Kazushi Morishita, Taiki Kohiki, Akira Shigenaga, Akira Otaka and Kazunori Matsuura : Light-induced propulsion of a giant liposome driven by peptide nanofibre growth, Scientific Reports, Vol.8, No.1, articlenumber-6243, 2018. ... Tsubasa Inokuma, Kohdai Nishida, Akira Shigenaga, Ken-ichi Yamada and Akira Otaka : Direct enantioselective indolylation of peptidyl imine for the synthesis of indolyl glycine-containing peptides, Heterocycles, Vol.97, No.2, 1269-1287, 2018. ... Akira Shigenaga, Naoto Naruse and Akira Otaka : ProteoFind: A script for finding proteins that are suitable for chemical synthesis, Tetrahedron, Vol.74, No.19, 2291-2297, 2018. ... Takahisa Jichu, Tsubasa Inokuma, Keisuke Aihara, Taiki Kohiki, Kohdai Nishida, Akira Shigenaga, Ken-ichi Yamada and Akira Otaka : A recyclable hydrophobic anchor-tagged asymmetric amino thiourea catalyst, ChemCatChem, Vol.10, No.16, 3402-3405, 2018. ... 小宮 千明, 月本 準, 上田 将弘, 森崎 巧也, 猪熊 翼, 重永 章, 伊藤 孝司, 大髙 章 : 発現タンパク質に適用可能な新規チオエステル合成法の開発, 創薬懇話会 2018 in 志賀島, 2018年6月. ... 大川内 健人, 成瀬 公人, 重永 章, 大髙 章 : 新規チオール触媒を利用した環状ペプチド合成法の開発, 創薬懇話会 2018 in 志賀島, (巻), (号), (頁), 2018年6月. ... 榊原 拓哉, 猪熊 翼, 重永 章, 大髙 章, 山田 健一 : 安定なイミンを用いたα-アミノリン酸の実用的不斉合成, 創薬懇話会 2018 in 志賀島, (巻), (号), (頁), 2018年6月. ... 大髙 章 : 弁証法的薬学教育観-薬学における有機化学教育を考える-, 有機合成化学協会誌, Vol.76, No.7, 667, 2018年7月. ... 小宮 千明, 月本 準, 上田 将弘, 森崎 巧也, 猪熊 翼, 重永 章, 伊藤 孝司, 大髙 章 : 加水分解酵素を利用したC末端特異的チオエステル化反応の開発, 第50回若手ペプチド夏の勉強会, 2018年8月. ... 成瀬 公人, 大川内 健人, 猪熊 翼, 重永 章, 大髙 章 : On-resinチオエス テル化法から得られた知見とその応用, 第50回若手ペプチド夏の勉強会, (巻), (号), (頁), 2018年8月. ... 森崎 巧也, 中山 淳, 難波 康祐, 重永 章, 大髙 章 : トレーサブルリンカー を用いた共有結合性低分子の標的同定, 第50回若手ペプチド夏の勉強会, (巻), (号), (頁), 2018年8月. ... 大川内 健人, 森本 恭平, 成瀬 公人, 重永 章, 金井 求, 大髙 章 : 新規チオ ール触媒を利用した分子内ライゲーション法の開発, 第50回若手ペプチド夏の勉強会, (巻), (号), (頁), 2018年8月. ... 河野 誉良, 成瀬 公人, 猪熊 翼, 重永 章, 大髙 章 : N-Sアシル基転移速度 の向上を指向した新規補助基の開発, 第50回若手ペプチド夏の勉強会, (巻), (号), (頁), 2018年8月. ... 安養寺 啓太央, 粟飯原 圭祐, 吉丸 哲郎, 重永 章, 片桐 豊雅, 大髙 章 : がん 抑制タンパク質PHB2からの創薬シード発掘, 第50回若手ペプチド夏の勉強会, (巻), (号), (頁), 2018年8月. ... 上田 将弘, 小宮 千明, 重永 章, 大髙 章 : 酵素を利用したチオエステル調製 のためのC末ペプチド配列の最適化, 第50回若手ペプチド夏の勉強会, (巻), (号), (頁), 2018年8月. ... 中西 雅之, 古曳 泰規, 重永 章, 大髙 章, 田中 信忠, 北出 幸夫, 日野 真美, 野元 裕 : S-アデノシルホモシステイン加水分解酵素の蛍光性基質の開発, 第91回日本生化学会大会, 2018年9月. ... 大髙 章 : 自然に学ぶタンパク質化学, ペプチド研究所 フィッシャー祭, (巻), (号), (頁), 2018年10月. ... 上田 将弘, 小宮 千明, 重永 章, 大髙 章 : 酵素を利用したチオエステル化反応の効率化を指向したペプチドC末配列の修飾, 第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, (巻), (号), (頁), 2018年11月. ... 森崎 巧也, 重永 章, 大髙 章 : SECmideを基盤としたターンオン型蛍光クリーバブルリンカーの開発, 第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, (巻), (号), (頁), 2018年11月. ... 岩瀬 璃奈, 成瀬 公人, 種子島 幸祐, 重永 章, 大髙 章, 原 孝彦 : CXCL14とCpG DNAの相互作用によるTLR9活性化の特異性と責任領域の解析, 第41回日本分子生物学会年会, (巻), (号), (頁), 2018年11月. ... 三井 貴洋, 種子島 幸祐, 成瀬 公人, 重永 章, 大髙 章, 原 孝彦 : CpG DNA/CXCL14複合体に対する候補受容体の発現クローニング, 第41回日本分子生物学会年会, (巻), (号), (頁), 2018年11月. ... Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka : Preparation of protein thioesters enabled by carboxypeptidase-mediated C-terminal specific hydrazinolysis, 10th International Peptide Symposium, Kyoto, Dec. 2018. ... Naoto Naruse, Kiyoka Matsumoto, Akira Shigenaga and Akira Otaka : Development of method for deprotection of N-terminal thiazolidine derivative using copper salt for chemical protein synthesis, 10th International Peptide Symposium, (巻), (号), (頁), Kyoto, Dec. 2018. ... Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka : Development of anti-cancer peptide based on prohibitin 2, 10th International Peptide Symposium, (巻), (号), (頁), Kyoto, Dec. 2018. ... Kento Ohkawachi, Kyohei Morimoto, Naoto Naruse, Kenzo Yamatsugu, Akira Shigenaga, Motomu Kanai and Akira Otaka : Development of methodology for cyclic peptide synthesis using a thiol-incorporated DMAP catalyst, 10th International Peptide Symposium, (巻), (号), (頁), Kyoto, Dec. 2018. ... Taiki Kohiki, Yusuke Kato, Masaya Denda, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka : Development and application of novel protein labeling reagent "SEAL", 10th International Peptide Symposium, (巻), (号), (頁), Kyoto, Dec. 2018. ... Takuya Morisaki, Akira Shigenaga and Akira Otaka : Development of a turn-on fluorescent traceable linker employing N-sulfanylethylcoumarinyl amide for enrichment and visualization of target proteins Current Topic Drug Discovery: Recent Progress and the Future, Chemical & Pharmaceutical Bulletin, Vol.68, No.3, 216-219, 2019. ... 安養寺 啓太央, 粟飯原 圭佑, 吉丸 哲郎, 重永 章, 片桐 豊雅, 大髙 章 : がん抑制タンパク質PHB2を基盤とした新規創薬シーズの開発, 日本薬学会第139年会, (巻), (号), (頁), 2019年3月. ... 成瀬 公人, 重永 章, 大髙 章 : タンパク質合成を指向したチアゾリジン誘導体の脱保護法の開発, 日本薬学会第139年会, (巻), (号), (頁), 2019年3月. ... Naoto Naruse, Kiyoka Matsumoto, Akira Shigenaga and Akira Otaka : Development of method for deprotection of N-terminal thiazolidine derivative using copper salt for chemical protein synthesis, Peptide Science 2018, (巻), (号), 80, 2019. ... Kento Ohkawachi, Kyohei Morimoto, Naoto Naruse, Kenzo Yamatsugu, Akira Shigenaga, Motomu Kanai and Akira Otaka : Development of methodology for cyclic peptide synthesis using a thiol-incorporated DMAP catalyst, Peptide Science 2018, (巻), (号), 81, 2019. ... Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka : Development of anti-cancer peptide based on prohibitin 2, Peptide Science 2018, (巻), (号), 46, 2019. ... Taiki Kohiki, Yusuke Kato, Masaya Denda, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka : Development and application of novel protein labeling reagent "SEAL", Peptide Science 2018, (巻), (号), 104, 2019. ... Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka : Preparation of protein thioesters enabled by carboxypeptidase-mediated C-terminal specific hydrazinolysis, Peptide Science 2018, 8, 2019. ... 大髙 章 : 天然に学ぶタンパク質化学とタンパク・ペプチド性医薬品の可能性, 神戸ポートアイランド創薬フォーラム, (巻), (号), (頁), 2019年6月. ... Chiaki Komiya, Akira Shigenaga, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Kouji Itou and Akira Otaka : Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of cysteinyl prolyl sequence, Chemical Communications, Vol.55, 7029-7032, 2019. ... 安養寺 啓太央, 粟飯原 圭佑, 吉丸 哲郎, 重永 章, 片桐 豊雅, 大髙 章 : がん抑制因子PHB2の部分配列を基盤とした乳がん阻害ペプチドの開発, 創薬懇話会2019 in 秋保, (巻), (号), (頁), 2019年6月. ... 小林 大志朗, 成瀬 公人, 重永 章, 大髙 章 : 銅塩を基点とする，タンパク合成を指向した反応開発研究, 創薬懇話会2019 in 秋保, (巻), (号), (頁), 2019年6月. ... Naoto Naruse, Daishiroh Kobayashi, Kento Ohkawachi, Akira Shigenaga and Akira Otaka : Development of Novel Ring-Opening Reaction of N-Terminal Thiazolidine for Chemical Protein Synthesis, 26th American Peptide Symposium/11th International Peptide Symposium, (巻), (号), (頁), Monterey, CA, USA, June 2019. ... 大川内 健人, 森本 恭平, 成瀬 公人, 山次 健三, 重永 章, 金井 求, 大髙 章 : チオール導入型DMAP触媒を利用した環状ペプチド合成法の開発, 第51回若手ペプチド夏の勉強会, (巻), (号), (頁), 2019年8月. ... Naoto Naruse, Daishiroh Kobayashi, Akira Shigenaga and Akira Otaka : Copper-mediated Ring Opening of Thiazolidine Derivative for Protein Chemical Synthesis, 27th International Society of Heterocyclic Chemistry Congress, Kyoto, Sep. 2019. ... 重永 章 : 創薬標的の同定・解析を可能とする革新的ツールの創製, 2019年度さきがけ疾患代謝領域研究会, (巻), (号), (頁), 2019年10月. ... 小林 大志朗, 西田 航大, 猪熊 翼, 重永 章, 大髙 章 : Lossen rearrangement-mediated preparation of N-glyoxylyl peptide without addition of oxidant, 第56回ペプチド討論会, (巻), (号), (頁), 2019年10月. ... Tsubasa Inokuma, Kana Masui, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : Development of the direct asymmetric indolylation of imino peptide for synthesis of indolylglycine-containing peptide, 第56回ペプチド討論会, Oct. 2019. ... 小林 大志朗, 成瀬 公人, 重永 章, 大髙 章 : 銅塩を利用するシステインS-保護基除去反応の開発, 第45回反応と合成の進歩シンポジウム, 2019年10月. ... 中川 美帆, 種子島 幸祐, 三井 貴洋, 成瀬 公人, 重永 章, 大髙 章, 佐久間 啓, 原 孝彦 : ケモカイン CXCL14の脳内ミクログリアに対する働き, 第42回日本分子生物学会年会, (巻), (号), (頁), 2019年12月. ... 種子島 幸祐, 三井 貴洋, 岩瀬 璃奈, 成瀬 公人, 重永 章, 大髙 章, 原 孝彦 : CpG DNAと CXCL14による自然免疫系の協調的な調節メカニズム, 第42回日本分子生物学会年会, (巻), (号), (頁), 2019年12月. ... 大髙 章 : 人工タンパク質創製のためのタンパク質チオエステル調製法の開発, 日本プロセス化学会2019ウィンターシンポジウム, 2019年12月. ... 重永 章, 大髙 章 : 有機化学的視点からの標的タンパク質精製・機能解明ツールの開発, 生化学, Vol.91, No.6, 795-799, 2019年12月. ... Naoto Naruse, Daishiroh Kobayashi, Kento Ohkawachi, Akira Shigenaga and Akira Otaka : Copper-mediated deprotection of thiazolidine and selenazolidine derivatives applied to native chemical ligation, The Journal of Organic Chemistry, Vol.85, No.3, 1425-1433, 2020. ... 安養寺 啓太央, 粟飯原 圭佑, 吉丸 哲郎, 西川 祐輔, 小松 正人, 重永 章, 片桐 豊雅, 大髙 章 : 乳がん細胞におけるBIG3-PHB2相互作用を標的とした高持続性架橋ペプチドの開発, 日本薬学会第140年会, 2020年3月. ... 常松 保乃加, 上田 智子, 左東 大輝, 小宮 千明, 重永 章, 大髙 章 : S-Oアシル転移を基盤とする環状デプシペプチドの合成, 日本薬学会第140年会, (巻), (号), (頁), 2020年3月. ... Daishiroh Kobayashi, Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Lossen rearrangement-mediated preparation of N-glyoxylyl peptide without addition of oxidant, Peptide Science 2019, (巻), (号), 59, 2020. ... Kento Ohkawachi, Daishiroh Kobayashi, Kyohei Morimoto, Akira Shigenaga, Masaya Denda, Kenzo Yamatsugu, Motomu Kanai and Akira Otaka : Sulfanylmethyldimethylaminopyridine as a Useful Thiol Additive for Ligation Chemistry in Peptide/Protein Synthesis, Organic Letters, Vol.22, No.14, 5289-5293, 2020. ... Daishiroh Kobayashi, Naoto Naruse, Masaya Denda, Akira Shigenaga and Akira Otaka : Deprotection of S-Acetamidomethyl Cysteine with Copper (II) and 1,2-Aminothiols under Aerobic Conditions, Organic & Biomolecular Chemistry, Vol.18, (号), 8638-8645, 2020. ... Masahiro Ueda, Chiaki Komiya, Sayuki Arii, Kohshi Kusumoto, Masaya Denda, Keiichiro Okuhira, Akira Shigenaga and Akira Otaka : Sequence-independent traceless method for preparation of peptide/protein thioesters using CPaseY-mediated hydrazinolysis, Chemical & Pharmaceutical Bulletin, Vol.68, No.12, 1226-1232, 2020. ... Kento Ohkawachi, Daishiroh Kobayashi, Kyohei Morimoto, Akira Shigenaga, Masaya Denda, Kenzo Yamatsugu, Motomu Kanai and Akira Otaka : A new thiol additive for one-pot sequential peptide ligation-desulfurization chemistry, 第57回ペプチド討論会, (巻), (号), (頁), Nov. 2020. ... Daishiroh Kobayashi, Naoto Naruse, Masaya Denda, Akira Shigenaga and Akira Otaka : Deprotection of S-acetamidomethyl cysteine mediated by copper salts, 第57回ペプチド討論会, (巻), (号), (頁), Nov. 2020. ... Daiki Satoh, Honoka Tsunematsu, Tomoko Ueda, Chiaki Komiya, Masaya Denda, Akira Shigenaga and Akira Otaka : Development of a protection-free protocol for the synthesis of lactone peptides, 第57回ペプチド討論会, (巻), (号), (頁), Nov. 2020. ... Akira Otaka : Development of Desulfurization-compatible New Thiol Catalyst for Native Chemical Ligation, 18th Akabori Conference German-Japanese Symposium on Peptide Science, (巻), (号), (頁), Online, March 2021. ... 小林 大志朗, 光村 豊, 倉岡 瑛祐, 傳田 将也, 大髙 章 : S-保護システインスルホキシドを利用したCys-Trpチオエーテル結合形成反応の開発, 日本薬学会第141年会, (巻), (号), (頁), 2021年3月. ... 左東 大輝, 常松 保乃加, 上田 智子, 小宮 千明, 傳田 将也, 重永 章, 大髙 章 : 側鎖無保護ペプチドを用いた環状デプシペプチド簡便合成法の開発, 日本薬学会第141年会, (巻), (号), (頁), 2021年3月. ... 大髙 章 : 「1章 現場で必要な臨床医薬品化学とは，6章 糖尿病とその治療薬」現場で役に立つ!臨床医薬品化学 (臨床医薬品化学研究会 編), 株式会社 化学同人, (都市), 2021年4月. ... Daishiroh Kobayashi, Naoto Naruse, Masaya Denda, Akira Shigenaga and Akira Otaka : Deprotection of S-Acetamidomethyl Cysteine Mediated by Copper Salts, Peptide Science 2020, (巻), (号), 49-52, 2021. ... OHKAWACHI Kento, Daishiroh Kobayashi, Kyohei Morimoto, Akira Shigenaga, Masaya Denda, Kenzo Yamatsugu, Motomu Kanai and Akira Otaka : A New Thiol Additive for One-pot Sequential Peptide Ligation-Desulfurization Chemistry, Peptide Science 2020, (巻), (号), 25-26, 2021. ... 傳田 将也, 小宮 千明, 上田 将弘, 月本 準, 伊藤 孝司, 重永 章, 大髙 章 : 既存モダリティの高度化を指向したペプチド・タンパク質新規修飾法の開発, 日本薬剤学会第36年会, (巻), (号), (頁), 2021年5月. ... Jan Vincent V. Arafiles, Hisaaki Hirose, Yusuke Hirai, Masashi Kuriyama, Maxwell Mamfe Sakyiamah, Wataru Nomura, Kazuhiro Sonomura, Miki Imanishi, Akira Otaka, Hirokazu Tamamura and Shiroh Futaki : Discovery of a Macropinocytosis-Inducing Peptide Potentiated byMedium-Mediated Intramolecular Disulfide Formation, Angewandte Chemie International Edition, Vol.60, No.21, 11928-11936, 2021. ... 光村 豊, 小林 大志朗, 杉木 俊彦, 吉丸 哲郎, 倉岡 瑛祐, 傳田 将也, 藤原 敏道, 片桐 豊雅, 大髙 章 : Cys-Trp 架橋型乳がん抑制ペプチド(ERAP)の合成及び活性評価, 創薬懇話会2021 in 京都, (巻), (号), (頁), 2021年6月. ... 安崎 快登, 大川内 健人, 小林 大志朗, 喜屋武 龍二, 傳田 将也, 重永 章, 大髙 章 : 保護Cysスルホキシドを利用したS–Aryl化環状ペプチド合成研究, 創薬懇話会2021 in 京都, (巻), (号), (頁), 2021年6月. ... Rina Iwase, Naoto Naruse, Miho Nakagawa, Risa Saito, Akira Shigenaga, Akira Otaka, Takahiko Hara and Kosuke Tanegashima : Identification of Functional Domains of CXCL14 Involved in High-Affinity Binding and Intracellular Transport of CpG DNA, The Journal of Immunology, Vol.207, No.2, 459-469, 2021. ... Daishiroh Kobayashi, Yutaka Kohmura, Toshihiko Sugiki, Eisuke Kuraoka, Masaya Denda, Toshimichi Fujiwara and Akira Otaka : Peptide Cyclization Mediated by Metal-Free S-Arylation: S-Protected Cysteine Sulfoxide as an Umpolung of Cysteine Nucleophile, Chemistry - A European Journal, Vol.27, No.56, 14092-14099, 2021. ... 安崎 快登, 大川内 健人, 小林 大志朗, 喜屋武 龍二, 傳田 将也, 重永 章, 大髙 章 : Acm 保護 Cys スルホキシドを利用した化学選択的 S-Aryl 化反応開発研究, 第53回若手ペプチド夏の勉強会, (巻), (号), (頁), 2021年8月. ... 野中 智貴, 大川内 健人, 傳田 将也, 大髙 章 : Sulfanylmethyl DMAPを利用した環状ペプチド合成に関する研究, 第53回若手ペプチド夏の勉強会, (巻), (号), (頁), 2021年8月. ... 小林 大志朗, 光村 豊, 林 隼矢, 傳田 将也, 大髙 章 : 銅添加を鍵としたシステイン-トリプトファン間架橋反応の開発研究, 第53回若手ペプチド夏の勉強会, (巻), (号), (頁), 2021年8月. ... Daishiroh Kobayashi, Yutaka Kohmura, Junya Hayashi, Masaya Denda, Koichiro Tsuchiya and Akira Otaka : Copper (II)-mediated C-H sulphenylation or selenylation of tryptophan enabling macrocyclization of peptides, Chemical Communications, Vol.57, 10763-10766, 2021. ... Daishiroh Kobayashi, Yutaka Kohmura, Junya Hayashi, Masaya Denda and Akira Otaka : Development of copper and iron-mediated Cys-Trp-linking reaction, 第58回ペプチド討論会, (巻), (号), (頁), Oct. 2021. ... 安崎 快登, 大川内 健人, 小林 大志朗, 喜屋武 龍二, 傳田 将也, 重永 章, 大髙 章 : RESIDUE-SPECIFIC MODIFICATION REACTION USING S-ACETAMIDOMETHYL CYSTEINE SULFOXIDE, Cys(Acm)(O), 第58回ペプチド討論会, (巻), (号), (頁), 2021年10月. ... Daiki Sato, Masaya Denda, Honoka Tsunematsu, Naonobu Tanaka, Isamu Konishi, Chiaki Komiya, Akira Shigenaga and Akira Otaka : Late-stage macrolactonisation enabled by tandem acyl transfers followed by desulphurisation, Chemical Communications, Vol.58, No.17, 2918-2921, 2022. ... 左東 大輝, 常松 保乃加, 小西 勇夢, 上田 智子, 小宮 千明, 傳田 将也, 重永 章, 大髙 章 : 側鎖無保護ペプチドへの適用可能な合成後期ラクトン化法の開発, 日本薬学会第142年会, (巻), (号), (頁), 2022年3月. ... 光村 豊, 小林 大志朗, 傳田 将也, 大髙 章 : MBzl保護システインスルホキシドの芳香族化合物に対する反応性評価とペプチド架橋法への応用展開, 日本薬学会第142年会, (巻), (号), (頁), 2022年3月. ... 小林 大志朗, 倉岡 瑛祐, 光村 豊, 林 隼矢, 傳田 将也, 大髙 章 : S-保護システインスルホキシドを利用したトリプトファン選択的修飾反応の開発研究, 日本薬学会第142年会, (巻), (号), (頁), 2022年3月. ... Daishiroh Kobayashi, Yutaka Kohmura, Junya Hayashi, Masaya Denda and Akira Otaka : Development of copper and iron-mediated Cys-Trp-linking reaction, Peptide Science 2021, (巻), (号), 9-12, 2022. ... Kaito Anzaki, OHKAWACHI Kento, Daishiroh Kobayashi, Kyan Ryuji, Masaya Denda, Akira Shigenaga and Akira Otaka : Residue-Specific Modification Reaction Using S-Acetamidomethyl Cysteine Sulfoxide, Cys(Acm)(O), Peptide Science 2021, (巻), (号), 55-56, 2022. ... Masaya Denda and Akira Otaka : Advances in Preparation of Peptide and Protein Thioesters Aiming to Use in Medicinal Sciences, Chemical & Pharmaceutical Bulletin, Vol.70, No.5, 316-323, May 2022. ... Daishiroh Kobayashi, KURAOKA Eisuke, Junya Hayashi, Takuma Yasuda, Yutaka Kohmura, Masaya Denda, Norio Harada, Nobuya Inagaki and Akira Otaka : S-Protected cysteine sulfoxide-enabled tryptophan-selective modification with application to peptide lipidation, ACS Medicinal Chemistry Letters, Vol.13, No.7, 1125-1130, 2022. ... 林 隼矢, 小林 大志朗, 傳田 将也, 大髙 章 : Lossen転位を起点とした合成後期ペプチド主鎖ヘテロ化反応の開発, 創薬懇話会2022 in 名古屋, (巻), (号), (頁), 2022年7月. ... 小林 大志朗, 林 隼矢, 日高 功太, 大川内 健人, 光村 豊, 傳田 将也, 大髙 章 : 保護システインスルホキシドを利用したペプチド・タンパク質Trp残基選択的修飾法の開発研究, 第54回若手ペプチド夏の勉強会, (巻), (号), (頁), 2022年8月. ... 林 隼矢, 小林 大志朗, 傳田 将也, 大髙 章 : ペプチド主鎖修飾反応の開発とチオエーテル含有環状ペプチド合成への展開, 第54回若手ペプチド夏の勉強会, (巻), (号), (頁), 2022年8月. ... JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka : DEVELOPMENT OF INTRAMOLECULAR THIOETHERIFICATION ON PEPTIDE BACKBONE FOR CHEMICAL SYNTHESIS OF SACTIPEPTIDE, 第59回ペプチド討論会, (巻), (号), (頁), Oct. 2022. ... 日高 功太, 小林 大志朗, 林 隼矢, 大川内 健人, 傳田 将也, 大髙 章 : DEVELOPMENT OF ONE-POT/STEPWISE DISULFIDE BOND-FORMING REACTION ENABLED BY S-PROTECTED CYSTEINE SULFOXIDE WITH ITS APPLICATION TO INSULIN SYNTHESIS, 第59回ペプチド討論会, (巻), (号), (頁), 2022年10月. ... 日高 功太, 小林 大志朗, 林 隼矢, 大川内 健人, 傳田 将也, 大髙 章 : S-保護システインスルホキシドを利用したトリプトファン選択的修飾反応の開発とペプチドヘテロ二量化法への応用展開, 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, (巻), (号), (頁), 2022年11月. ... 大平 実佳, 大川内 健人, 安崎 快登, 北條 三奈, 水口 仁志, 傳田 将也, 大髙 章 : スルフェニル化Tyrを利用したTyr-Tyrビアリール構造含有ペプチド合成法の開発, 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, (巻), (号), (頁), 2022年11月. ... 左東 大輝 : 巨大分子のカタチを制御する, 未来博士3分間コンペティション2022, (巻), (号), (頁), 2022年11月. ... 野中 智貴, 小林 大志朗, 倉岡 瑛祐, 林 隼矢, 安田 拓真, 光村 豊, 傳田 将也, 原田 範雄, 稲垣 暢也, 大髙 章 : S-保護システインスルホキシドを利用したトリプトファン選択的脂肪鎖修飾法の開発と応用, 第39回メディシナルケミストリーシンポジウム, (巻), (号), (頁), 2022年11月. ... 林 隼矢, 小林 大志朗, 傳田 将也, 大髙 章 : アシルイミニウムカチオンを経由したペプチド主鎖修飾反応の開発, 第48回反応と合成の進歩シンポジウム, (巻), (号), (頁), 2022年11月. ... OHKAWACHI Kento, Kaito Anzaki, Daishiro Kobayashi, Ryuji Kyan, Takuma Yasuda, Masaya Denda, Norio Harada, Akira Shigenaga, Nobuya Inagaki and Akira Otaka : Residue-selective CH sulfenylation enabled by acid-activated S-acetamidomethyl cysteine sulfoxide with application to one-pot stapling and lipidation sequence, Chemistry - A European Journal, (巻), (号), (頁), 2023. ... 左東 大輝, 篠﨑 千穂, 傳田 将也, 大髙 章 : 連続アシル転移を利用した分子内および分子間スレオニン側鎖アシル化法の開発, 日本薬学会第143年会, (巻), (号), (頁), 2023年3月. ... 大川内 健人, 安崎 快登, 小林 大志朗, 喜屋武 龍二, 傳田 将也, 重永 章, 大髙 章 : S-保護システインスルホキシドを利用した残基選択的C-Hスルフェニル化反応の開発, 日本薬学会第143年会, (巻), (号), (頁), 2023年3月. ... Akira Otaka, OHKAWACHI Kento, Kaito Anzaki and Masaya Denda : Tyr- or Trp-selective CH sulfenylation enabled by acid- activated S-acetamidomethyl cysteine sulfoxide, 19th Akabori Conference German-Japanese Symposium on Peptide Science, 大津市, May 2023. ... 傳田 将也, 野中 智貴, 小林 大志朗, 林 隼矢, 安田 拓真, 光村 豊, 原田 範雄, 稲垣 暢也, 大髙 章 : S-保護システインスルホキシドを利用したトリプトファン選択的修飾法の開発, 日本ケミカルバイオロジー学会 第17回年会, 2023年5月. ... 左東 大輝, 篠﨑 千穂, 傳田 将也, 大髙 章 : ユビキチン化の機能解明を志向した新規スレオニン側鎖アシル化法の開発, 日本ケミカルバイオロジー学会 第17回年会, 2023年5月. ... 日高 功太, 小林 大志朗, 林 隼矢, 大川内 健人, 傳田 将也, 大髙 章 : 保護システインスルホキシドを用いたワンポット連続ジスルフィド形成 によるインスリンの合成研究, 創薬懇話会2023 湯河原, 2023年6月. ... Chiho Shinozaki, Yutaka Kohmura, Tetsuro Yoshimaru, Tsuyoshi Tahara, Masaya Denda, Hidefumi Mukai, Kohta Mohri, Yi Long Chen, Toyomasa Katagiri and Akira Otaka : Study on a lipidated anti-cancer peptide allowing long-lasting duration in mice model, AIMECS 2023, Seoul, June 2023. ... Mika Ohhira, OHKAWACHI Kento, Kaito Anzaki, Mina Hojo, Sayaka Tani, Masaya Denda, Hitoshi Mizuguchi and Akira Otaka : Development of synthetic method for synthesizing di-Tyr-containing bi-aryl peptides enabled by oxidation of sulfenyl Tyr, AIMECS 2023, (巻), (号), (頁), Seoul, June 2023. ... 大髙 章 : 「4章 『失敗の言語化』が拓いたリバイバル研究」ドラマチック有機合成化学 感動の瞬間100 (有機合成化学協会 編), 株式会社 化学同人, (都市), 2023年7月. ... Takashi Tsuji, Honoka Tsunematsu, Masaki Imanishi, Masaya Denda, Koichiro Tsuchiya and Akira Otaka : Enhanced tumor specific drug release by hypoxia sensitive dual-prodrugs based on 2-nitroimidazole, Bioorganic & Medicinal Chemistry Letters, (巻), (号), 129484, 2023. ... Daishiro Kobayashi, JUNYA Hayashi, Kohta Hidaka, OHKAWACHI Kento, Yutaka Kohmura, Masaya Denda and Akira Otaka : Protein tryptophan modification enabled by using S-protected cysteine sulfoxide under mild acid conditions, 13th International Peptide Symposium 15th Australian Peptide Conference, (巻), (号), (頁), Brisbane, Oct. 2023. ... JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka : DEVELOPMENT OF OXIDANT FREE METHODOLOGY FOR PREPARING N-GLYOXYLYL PEPTIDE AND ITS APPRICATIONS, 13th International Peptide Symposium 15th Australian Peptide Conference, (巻), (号), (頁), Brisbane, Oct. 2023. ... Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka : DEVELOPMENT OF ONE-POT/STEPWISE DISULFIDE BOND-FORMING REACTION ENABLED BY S-PROTECTED CYSTEINE SULFOXIDE WITH ITS APPLICATION TO SYNTHESIS OF INSULIN AND ITS LIPIDATED ANALOGUE, 13th International Peptide Symposium 15th Australian Peptide Conference, (巻), (号), (頁), Brisbane, Oct. 2023. ...
過去3日以内に登録・変更された情報
|
Takashi Tsuji, Honoka Tsunematsu, Masaki Imanishi, Masaya Denda, Koichiro Tsuchiya and Akira Otaka : Enhanced tumor specific drug release by hypoxia sensitive dual-prodrugs based on 2-nitroimidazole, Bioorganic & Medicinal Chemistry Letters, (巻), (号), 129484, 2023.---(Modified by 新見 優子 at 2023年9月21日(木) 15:42:20) | ... | ||
|
OHKAWACHI Kento, Kaito Anzaki, Daishiro Kobayashi, Ryuji Kyan, Takuma Yasuda, Masaya Denda, Norio Harada, Akira Shigenaga, Nobuya Inagaki and Akira Otaka : Residue-selective CH sulfenylation enabled by acid-activated S-acetamidomethyl cysteine sulfoxide with application to one-pot stapling and lipidation sequence, Chemistry - A European Journal, (巻), (号), (頁), 2023.---(Modified by 大髙 章 at 2023年9月20日(水) 14:45:11) | ... |
無効な情報 (13件)
-
H Tamamura, T Murakami, S Horiuchi, K Sugihara, Akira Otaka, W Takada, T Ibuka, M Waki, N Yamamoto and N Fujii : Synthesis of Protegrin-related Peptides and their Antibacterial and Anti-Human Immunodeficiency Virus Activity., Chemical & Pharmaceutical Bulletin, Vol.45, (号), 853-858, 1995. Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Shugo Tsuda, Kouji Itou and Akira Otaka : Synthesis of a nucleocytoplasmic shuttle peptide possessing a stimulus-responsive amino acid, ACS Chemical Biology, Vol.1, (号), 7-10, 2008. S.-M. Yun, T. Moulaei, D. Lim, J. K. Bang, J.-E. Park, S. R. Shenoy, F. Liu, Y. H. Kang, C. Liao, N.-K. Soung, S. Lee, D.-Y. Yoon, Y. Lim, D.-H. Lee, A. Otaka, E. Appella, J. B. McMahon, M. C. Nicklaus, T. Burke R. Jr., M. B. Yaffe, A. Wlodawer and K. S. Lee. : Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1., (発行所), (都市), July 2009. Kohei Sato, Shugo Tsuda, Kohei Tsuji, Ken Sakamoto, Akira Shigenaga and Akira Otaka : N-Sulfanylethylanilide derivative as a peptide thioester equivalent, Proceedings of the Twenty-Second American Peptide Symposium, (巻), (号), 72-73, 2011. 中村 太寛, 佐藤 浩平, 大高 章 : 刺激応答型アミノ酸の開発と生命科学分野への展開, 化学工業(特集 ペプチド化学の新潮流(1)), Vol.65, No.11, 842-848, 2014年11月. Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka : N-Sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins, Chemical Communications, Vol.in Press, 2016. Chiaki Komiya, Jun Tsukimoto, Takuya Morisaki, Yusuke Tsuda, Rin Miyajima, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka : Development of methodology for producing thioesters from naturally occurring peptide sequence, Peptide Science 2017, 86-87, 2018. Hiroshi Inaba, Akihito Uemura, K Morishita, Taiki Kohiki, Akira Shigenaga, Akira Otaka and Kazunori Matsuura : Light-induced propulsion of a giant liposome driven by peptide nanofibre growth, Scientific Reports, Vol.8, articlenumber-6243, 2018. 森崎 巧也, 中山 淳, 難波 康祐, 重永 章, 大髙 章 : トレーサブルリンカー を用いた共有結合性低分子の標的同定, 第50回若手ペプチド夏の勉強会, (巻), (号), (頁), 2018年8月. 森崎 巧也, 中山 淳, 難波 康祐, 重永 章, 大髙 章 : トレーサブルリンカー を用いた共有結合性低分子の標的同定, 第50回若手ペプチド夏の勉強会, (巻), (号), (頁), 2018年8月. 種子島 幸祐, 三井貴洋 (名), 岩瀬 璃奈, 成瀬 公人, 重永 章, 大髙 章, 原 孝彦 : CpG DNAと CXCL14による自然免疫系の協調的な調節メカニズム, 第42回日本分子生物学会年会, (巻), (号), (頁), 2019年12月. Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka : DEVELOPMENT OF ONE-POT/STEPWISE DISULFIDE BOND-FORMING REACTION ENABLED BY S-PROTECTED CYSTEINE SULFOXIDE WITH ITS APPLICATION TO SYNTHESIS OF INSULIN AND ITS LIPIDATED ANALOGUE, 13th International Peptide Symposium 15th Australian Peptide Conference, (巻), (号), (頁), Brisbane, Oct. 2023. (著者) : 新しい薬をどう創るか, --- 創薬研究の最前線 ---, 講談社, (都市), (年月日).
本データベースでは情報の登録，保守作業の分散を主たる目的の一つとしております．したがって，上記にリストアップされている情報の保守は個々の情報の当事者に委ねられます．
ある情報を保守する義務があるかないかは，その情報に対して権限を持っているかどうかで判断してください．もちろん情報の所有者が主に管理しなくてはならないことになりますが，権限を持っている利用者が連帯してその情報の保守を行なう義務を負っていると考えてください．
貴方がどの情報について権限を持っているかは，貴方自身の情報を閲覧してください．
Number of session users = 0, LA = 0.24, Max(EID) = 403211, Max(EOID) = 1091521.