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著作: [表原 文江]/Nakashiro Koh-ichi/[内田 大亮]/Hino Satoshi/Fujimori Takahiro/Transcriptional activation of cyclin-dependent kinasa inhibitor, p21waf1 gene by treatment with a differentiation inducing agent, vesnarinone in a human salivary gland cancer cell line/[Journal of Experimental & Clinical Cancer Research]

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EID
99727
EOID
836223
Map
0
LastModified
2016年9月9日(金) 16:21:54
Operator
三木 ちひろ
Avail
TRUE
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Owner
[学科長]/[徳島大学.歯学部.歯学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 表原 文江
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Nakashiro Koh-ichi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 内田 大亮
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Hino Satoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Fujimori Takahiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Transcriptional activation of cyclin-dependent kinasa inhibitor, p21waf1 gene by treatment with a differentiation inducing agent, vesnarinone in a human salivary gland cancer cell line

副題 任意
要約 任意

(英) Recently, a new concept for cancer therapy termed "tumor dormancy therapy" has been proposed. The concept of this therapy is to prolong the survival time of cancer patients while maintaining their quality of life. We have been developing a differentiation-inducing therapy, which is included in the tumor dormancy therapy, for salivary gland cancer. In this study, we examined the effect of a differentiation-inducing drug, Vesnarinone on the growth of several cancer cells, and examined the molecular mechanism by which Vesnarinone induces the cyclin dependent kinase inhibitor, p21waf1 in the cancer cells. Vesnarinone significantly suppressed the growth of TYS (salivary gland cancer cells), PC3 (prostate cancer cells), and A431 (squamous cell cancer cells). Furthermore, Vesnarinone dose-dependently enhanced the expression of p21waf1 mRNA in TYS cells. Using the luciferase reporter assay it was found that the enhancement of p21waf1 mRNA expression by Vesnarinone was through direct transcriptional activation of the p21waf1 promoter. Thus, analyzing the molecular mechanisms of differentiation inducing drugs may lead to the development of a new therapeutic strategy for several human malignancies, including salivary gland cancer.

キーワード 推奨
  1. (英) Antineoplastic Agents
  2. 細胞分化(cell differentiation)
  3. 細胞分裂(cell division)
  4. (英) Cyclin-Dependent Kinase Inhibitor p21
  5. (英) Cyclin-Dependent Kinases
  6. (英) Cyclins
  7. (英) Enzyme Inhibitors
  8. (英) Gene Expression Regulation, Neoplastic
  9. (英) Humans
  10. (英) Plasmids
  11. (英) Quinolines
  12. (英) RNA, Messenger
  13. (英) Salivary Gland Neoplasms
  14. (英) Transcriptional Activation
  15. (英) Tumor Cells, Cultured
発行所 推奨
誌名 必須 Journal of Experimental & Clinical Cancer Research([BioMed Central Ltd.])
(pISSN: 0392-9078, eISSN: 1756-9966)
ISSN 任意 0392-9078
ISSN: 0392-9078 (pISSN: 0392-9078, eISSN: 1756-9966)
Title: Journal of experimental & clinical cancer research : CR
Title(ISO): J. Exp. Clin. Cancer Res.
Publisher: BioMed Central
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 22
必須 14
必須 57 60
都市 任意
年月日 必須 2003年 3月 初日
URL 任意
DOI 任意
PMID 任意 12725323    (→Scopusで検索)
NAID 任意
WOS 任意 000182019400008
Scopus 任意 2-s2.0-12244304143
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Dept. of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimo-tsuga, Tochigi, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't