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著作: [姚 陳娟]/Wei Wei/[李 雪飛]/[細井 和雄]/Acute phase protein induction by experimental inflammation in the salivary gland/[Journal of Oral Pathology & Medicine]

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2012年11月2日(金) 22:00:28
Operator
大家 隆弘
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細井 和雄
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 姚 陳娟([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Wei Wei
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 李 雪飛
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 細井 和雄
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Acute phase protein induction by experimental inflammation in the salivary gland

副題 任意
要約 任意

(英) The submandibular gland (SMG) is a major salivary gland, which plays an important role in maintenance the oral health. In this study, we intended to explore the role of the SMG's defense system of the animals in which experimental inflammation is induced. The levels of mRNAs for inflammation cytokines and acute phase proteins were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). The mRNAs for acute phase proteins were found to be increased in the SMG and extraorbital and intraorbital lacrimal gland (ELG and ILG) of rats at 24 h after subcutaneous injection of turpentine oil. The induction of mRNA for these inflammatory proteins by turpentine oil was preceded by a transient increase in the level of mRNAs for IL-1beta, IL-6 and TNF-alpha at 6 h after subcutaneous injection of the oil. Such cytokine induction was similarly seen by lipopolysaccharide (LPS) injection, and involvement of Toll-like receptor 4 (TLR4) was strongly suggested from experiment using C3H/HeJ mice, a TLR4-deficient mutant strain. The up-regulation of acute phase proteins and inflammation cytokines in the SMG, ELG and ILG by experimental inflammation suggests the existence of a strict defense system via the innate immune system in the SMG and other exocrine gland.

キーワード 推奨
  1. (英) Acute-Phase Proteins
  2. (英) Animals
  3. (英) Cysteine Proteinase Inhibitors
  4. (英) Cytokines
  5. (英) Interleukin-1
  6. (英) Interleukin-6
  7. (英) Irritants
  8. (英) Kininogens
  9. (英) Lacrimal Apparatus
  10. (英) Lipopolysaccharides
  11. (英) Male
  12. (英) Membrane Glycoproteins
  13. (英) Mice
  14. (英) Mice, Inbred C3H
  15. (英) Mice, Inbred Strains
  16. (英) Mice, Mutant Strains
  17. (英) Rats
  18. (英) Rats, Wistar
  19. (英) Receptors, Cell Surface
  20. (英) Sialadenitis
  21. (英) Submandibular Gland Diseases
  22. (英) Time Factors
  23. (英) Toll-Like Receptor 4
  24. (英) Toll-Like Receptors
  25. (英) Tumor Necrosis Factor-alpha
  26. (英) Turpentine
  27. (英) Up-Regulation
発行所 推奨 Blackwell Publishing Ltd
誌名 必須 Journal of Oral Pathology & Medicine(International Association of Oral Pathologists/American Academy of Oral Pathology)
(pISSN: 0904-2512, eISSN: 1600-0714)
ISSN 任意 0904-2512
ISSN: 0904-2512 (pISSN: 0904-2512, eISSN: 1600-0714)
Title: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Title(ISO): J Oral Pathol Med
Supplier: International Association of Oral Pathologists
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 34
必須 6
必須 364 367
都市 任意 (英) Oxford
年月日 必須 2005年 7月 初日
URL 任意
DOI 任意 10.1111/j.1600-0714.2005.00321.x    (→Scopusで検索)
PMID 任意 15946185    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima, 770-8504, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article