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著作: Yano Yoko/Ozono Ryoji/Nakashima Hidekatu/Oishi Yoshihiko/Kambe Masayuki/[細井 和雄]/Oshima Tetsuya/Immunohistochemical distributions of the tissue kallikrein-kinin system in ischemic and non-ischemic mouse heart/[Journal of Cardiovascular Pharmacology]

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EID
98190
EOID
723828
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LastModified
2014年2月14日(金) 12:46:21
Operator
大家 隆弘
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細井 和雄
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種別 必須 国際会議
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
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著者 必須
  1. (英) Yano Yoko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Ozono Ryoji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Nakashima Hidekatu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Oishi Yoshihiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kambe Masayuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 細井 和雄
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Oshima Tetsuya
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Immunohistochemical distributions of the tissue kallikrein-kinin system in ischemic and non-ischemic mouse heart

副題 任意
要約 任意

(英) Kinins have been shown to play a cardioprotective role during myocardial ischemia. However, the localization of each of the components of the kallikrein-kinin system in the heart has not been determined in a cell type-specific manner. Recently, mK1 has been identified as the major tissue kallikrein with the strongest bradykinin-forming activity among the products of the mouse tissue kallikrein gene superfamily. In the study presented here, we investigated the localizations of mK1, kininogen and bradykinin B2 receptors (B2Rs) in ischemic and non-ischemic left ventricles by immunohistochemistry. Kininogen, which contains bradykinin as a surface epitope, was detected by an anti-bradykinin antibody. Changes in the amounts of mK1 and B2R were evaluated by Western blot analysis. Myocardial ischemia was induced by ligation of the left anterior descending coronary artery for 60 min followed by reperfusion for 24 h. mK1 and B2Rs were most abundantly expressed in the vascular endothelium and, to a lesser extent, in fibroblasts. No immunohistochemical signal of these molecules was detected in myocytes. Kininogen was localized in the vascular endothelium and the smooth muscle layer. Myocardial ischemia, although it had no effect on the localization of these molecules, increased the amounts of mK1 and B2R. We have obtained immunohistochemical evidence that all components of the tissue kallikrein-kinin system are present in the mouse heart. The coronary artery is the major site of kallikrein-kinin activity both in ischemic and non-ischemic hearts.

キーワード 推奨
  1. (英) Animals
  2. (英) Blotting, Western
  3. (英) Bradykinin
  4. (英) Coronary Vessels
  5. (英) Endothelium, Vascular
  6. (英) Epitopes
  7. (英) Heart Ventricles
  8. (英) Immunoenzyme Techniques
  9. (英) Kallikrein-Kinin System
  10. (英) Kininogen, High-Molecular-Weight
  11. (英) Kininogen, Low-Molecular-Weight
  12. (英) Ligation
  13. (英) Male
  14. (英) Mice
  15. (英) Mice, Inbred C57BL
  16. (英) Myocardial Ischemia
  17. (英) Receptor, Bradykinin B2
  18. (英) Reperfusion
  19. (英) Time Factors
  20. (英) Tissue Kallikreins
発行所 推奨
誌名 必須 Journal of Cardiovascular Pharmacology([Lippincott Williams & Wilkins])
(pISSN: 0160-2446, eISSN: 1533-4023)
ISSN 任意 0160-2446
ISSN: 0160-2446 (pISSN: 0160-2446, eISSN: 1533-4023)
Title: Journal of cardiovascular pharmacology
Title(ISO): J Cardiovasc Pharmacol
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 42
必須 Suppl.1
必須 S49 S53
都市 必須
年月日 必須 2003年 12月 初日
URL 任意
DOI 任意
PMID 任意 14871029    (→Scopusで検索)
NAID 任意
WOS 任意 000187044500012
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Clinical Laboratory Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Comparative Study

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't