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著作: [細井 和雄]/Tanaka, Izumi/Ishii, Yukihito/Ueha, Takao/A new esteroproteinase (proteinase F) from the submandibular gland of female mice/[Biochimica et Biophysica Acta (BBA) - General Subjects]

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98187
EOID
711566
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2013年9月11日(水) 21:21:04
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細井 和雄
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
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学究種別 推奨
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著者 必須
  1. 細井 和雄
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Tanaka, Izumi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Ishii, Yukihito
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Ueha, Takao
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) A new esteroproteinase (proteinase F) from the submandibular gland of female mice

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(英) One of the esteroproteinases present in the submandibular glands of female mice was purified and characterized. The enzyme, designated proteinase F in this report, had a pI value of 4.6 and a molecular weight of 27600, being comprised of two subunits of 10000 and 18000 daltons. The amino acid composition of proteinase F resembled that of the epidermal growth factor-binding protein, but antiserum against proteinase F only reacted weakly against the binding protein. Proteinase F had an optimum pH at around 9.0 and was strongly inhibited by Cu2+ and Hg2+ (42 and 76% inhibition, respectively, at a concentration of 4 x 10(-6) M). It was also inhibited by aprotinin, phenylmethylsulfonylfluoride, iodoacetamide, leupeptin, antipain, and benzamidine but neither by trypsin inhibitors from pancrease, soybean, or ovomucoid, nor by TLCK, TPCK, and epsilon-amino-n-caproic acid. Although its actual physiological function has yet to be determined, these properties indicate that proteinase F is a new enzyme, being distinguished from known proteinases, kallikrein, plasmin, trypsin, chymotrypsin, tonin, angiotensin-converting enzyme, proteinase A (beta-nerve growth factor endopeptidase), proteinase D (epidermal growth factor-binding protein), P-esterase, renin A, and renin C. Proteinase F was present in the submandibular glands of female mice more abundantly than in those of males, but it increased in males following castration. Thus, proteinase F appears to be affected by male hormones in vivo.

キーワード 推奨
  1. (英) Amino Acids
  2. (英) Animals
  3. (英) Castration
  4. (英) Chemical Phenomena
  5. (英) Chemistry
  6. (英) Endopeptidases
  7. (英) Female
  8. (英) Male
  9. (英) Mice
  10. (英) Mice, Inbred ICR
  11. (英) Protease Inhibitors
  12. (英) Serine Endopeptidases
  13. (英) Sex Factors
  14. (英) Submandibular Gland
発行所 推奨
誌名 必須 Biochimica et Biophysica Acta (BBA) - General Subjects([Elsevier Science])
(pISSN: 0304-4165)
ISSN 任意 0304-4165
ISSN: 0304-4165 (pISSN: 0304-4165, eISSN: 1872-8006)
Title: Biochimica et biophysica acta. General subjects
Title(ISO): Biochim Biophys Acta Gen Subj
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 756
必須 2
必須 163 170
都市 任意
年月日 必須 1983年 3月 31日
URL 任意
DOI 任意 10.1016/0304-4165(83)90088-0    (→Scopusで検索)
PMID 任意 6338933    (→Scopusで検索)
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WOS 任意
Scopus 任意
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被引用数 任意
指導教員 推奨
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  1. (英) Article.PublicationTypeList.PublicationType: Journal Article