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著作: [山本 裕史]/Liljestrand, M. Howard/Partitioning of selected estrogenic compounds between synthetic membrane vesicles and water: effects of lipid components/[Environmental Science and Technology]

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EID
96989
EOID
880113
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LastModified
2017年12月19日(火) 14:54:25
Operator
三木 ちひろ
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TRUE
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[学科長]/[徳島大学.総合科学部.社会創生学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
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著者 必須
  1. 山本 裕史
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Liljestrand, M. Howard
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Partitioning of selected estrogenic compounds between synthetic membrane vesicles and water: effects of lipid components

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(英) Partition coefficients of the steroid estrogens 17beta-estradiol, estriol, estrone, and 17alpha-ethynylestradiol and the industrial estrogenic compounds p-nonylphenol, p-(tert)octylphenol, bisphenol A, butylbenzylphthalate, and dibutylphthalate between liposome membrane vesicles and water (K(lipw) values) were determined using equilibrium dialysis. A moderate linear correlation with R2 values of as low as 0.679 were found for the relationship between log K(lipw) and log K(ow) for these compounds. Effects of lipid components used to prepare the membrane vesicles on the partitioning of 17beta-estradiol and p-nonylphenol were also evaluated. For both, K(lipw) values were larger for the vesicles prepared from phospholipids composed of shorter acyl chains such as dilauroyl-phosphatidylcholine than those composed of longer acyl chains such as distearoylphosphatidylcholine. Partition coefficients were higher for the vesicles prepared from phospholipids including unsaturated acyl chains such as dioleoyl-phosphatidylcholine than those solely composed of saturated acyl chains such as distearoyl-phosphatidylcholine. Both shorter acyl chains and double bonds resulted in a more fluid conformation of the lipid bilayer with the liquid crystalline phase rather than the gel phase and greater partitioning. In contrast, higher cholesterol contents reduced the partitioning coefficient. The presence of cholesterol in the void of the lipid bilayer possibly led to the stabilization of the bilayer and the decrease in the partitioning of 17beta-estradiol or p-nonylphenol molecules. These results suggest that phase transition is of critical importance in selecting lipid components to evaluate the bioconcentration for these compounds.

キーワード 推奨
  1. (英) Biological Availability
  2. (英) Cell Membrane
  3. (英) Estrogens
  4. リポソーム(liposomes)
  5. (英) Membranes, Artificial
  6. (英) Models, Theoretical
  7. (英) Water
発行所 推奨
誌名 必須 Environmental Science and Technology([アメリカ化学会])
(pISSN: 0013-936X, eISSN: 1520-5851)
ISSN 任意 0013-936X
ISSN: 0013-936X (pISSN: 0013-936X, eISSN: 1520-5851)
Title: Environmental science & technology
Title(ISO): Environ Sci Technol
Publisher: American Chemical Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 38
必須 4
必須 1139 1147
都市 任意
年月日 必須 2004年 2月 15日
URL 任意
DOI 任意
PMID 任意 14998029    (→Scopusで検索)
NAID 任意
WOS 任意 000188996600030
Scopus 任意 2-s2.0-1242342800
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Civil Engineering, The University of Texas at Austin, 1 University Station C1786, Austin, Texas 78712-0273, USA. yamamoto.hiroshi@nies.go.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article