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著作: 原田 顕治/[野村 昌弘]/[西角 彰良]/Uehara Kouzoh/[中屋 豊]/[伊東 進]/Clinical efficacy of efonidipine hydrochloride, a T-type calcium channel inhibitor, on sympathetic activities/[Circulation Journal]

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2014年8月27日(水) 16:18:03
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三木 ちひろ
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[学科長]/[徳島大学.医学部.医科栄養学科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Harada Kenji / (日) 原田 顕治
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 野村 昌弘
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 西角 彰良
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Uehara Kouzoh
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 中屋 豊
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 伊東 進
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Clinical efficacy of efonidipine hydrochloride, a T-type calcium channel inhibitor, on sympathetic activities

副題 任意

(英) Examination using spectral analysis of heat rate/blood pressure variabilities and 123I-metaiodobenzylguanidine myocardial scintigraphy

要約 任意

(英) Dihydropyridine Ca antagonists cause reflex tachycardia related to their hypotensive effects. Efonidipine hydrochloride has inhibitory effects on T-type Ca channels, even as it inhibits reflex tachycardia. In the present study, the influence of efonidipine hydrochloride on heart rate and autonomic nervous function was investigated. Using an electrocardiogram and a tonometric blood pressure measurement, autonomic nervous activity was evaluated using spectral analysis of heart rate/systolic blood pressure variability. Three protocols were used: (1) a single dose of efonidipine hydrochloride was administered orally to healthy subjects with resting heart rate values of 75 beats/min or more (high-HR group) and to healthy subjects with resting heart rate values less than 75 beats/min (low-HR group); (2) efonidipine hydrochloride was newly administered to untreated patients with essential hypertension, and autonomic nervous activity was investigated after a 4-week treatment period; and (3) patients with high heart rate values (>/=75 beats/min) who had been treated with a dihydropyridine L-type Ca channel inhibitor for 1 month or more were switched to efonidipine hydrochloride and any changes in autonomic nervous activity were investigated. In all protocols, administration of efonidipine hydrochloride decreased the heart rate in patients with a high heart rate, reduced sympathetic nervous activity, and enhanced parasympathetic nervous activity. In addition, myocardial scintigraphy with (123)I-metaiodobenzylguanidine showed significant improvement in the washout rate and H/M ratio of patients who were switched from other dihydropyridine Ca antagonists to efonidipine hydrochloride. Efonidipine hydrochloride inhibits increases in heart rate and has effects on the autonomic nervous system. It may be useful for treating hypertension and angina pectoris, and may also have a cardiac protective function.

キーワード 推奨
  1. (英) 3-Iodobenzylguanidine
  2. (英) Adult
  3. 血圧(blood pressure)
  4. (英) Calcium Channel Blockers
  5. (英) Dihydropyridines
  6. (英) Electrocardiography
  7. (英) Female
  8. 心臓(heart)
  9. (英) Heart Rate
  10. (英) Hemodynamics
  11. (英) Humans
  12. 高血圧(hypertension)
  13. (英) Iodine Radioisotopes
  14. (英) Male
  15. (英) Nitrophenols
  16. (英) Organophosphorus Compounds
  17. スペクトル解析(spectrum analysis)
  18. (英) Sympathetic Nervous System
  19. (英) Tachycardia
  20. (英) Treatment Outcome
発行所 推奨
誌名 必須 Circulation Journal([社団法人 日本循環器学会])
(pISSN: 1346-9843, eISSN: 1347-4820)
ISSN 任意 1346-9843
ISSN: 1346-9843 (pISSN: 1346-9843, eISSN: 1347-4820)
Title: Circulation journal : official journal of the Japanese Circulation Society
Title(ISO): Circ J
Supplier: 社団法人日本循環器学会
Publisher: Japanese Circulation Society/Nihon Junkanki Gakkai
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 67
必須 2
必須 139 145
都市 任意
年月日 必須 2003年 1月 25日
URL 任意
DOI 任意 10.1253/circj.67.139    (→Scopusで検索)
PMID 任意 12547996    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Digestive and Cardiovascular Medicine, University of Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article