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著作: [田中 克哉]/Ludwig LM/Krolilowski, JG/Alcindor D/Pratt PF/Kersten JR/Pagel PS/Warltier DC/Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2./[Anesthesiology]

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EID
94651
EOID
691850
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0
LastModified
2013年6月21日(金) 16:30:00
Operator
大家 隆弘
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Owner
田中 克哉
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. Medical College of Wisconsin
著者 必須
  1. 田中 克哉([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Ludwig LM
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Krolilowski, JG
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Alcindor D
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Pratt PF
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Kersten JR
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Pagel PS
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Warltier DC
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2.

副題 任意
要約 任意

(英) Whether volatile anesthetics produce a second window of preconditioning is unclear. The authors tested the hypothesis that isoflurane causes delayed preconditioning against infarction and, further, that cyclooxygenase (COX)-2 mediates this beneficial effect. Rabbits (n = 43) were randomly assigned to receive 0.9% intravenous saline, the selective COX-2 inhibitor celecoxib (3 mg/kg intraperitoneal) five times over 2 days before coronary artery occlusion and reperfusion, or isoflurane (1.0 minimum alveolar concentration) 24 h before acute experimentation in the absence or presence of celecoxib pretreatment. Two additional groups of rabbits received a single dose of celecoxib either 30 min before or 21.5 h after administration of isoflurane. Rabbits were then instrumented for measurement of hemodynamics and underwent 30 min of coronary occlusion followed by 3 h of reperfusion. Myocardial infarct size was measured using triphenyltetrazolium staining. Western immunoblotting to examine COX-1 and COX-2 protein expression was performed in rabbit hearts that had or had not been exposed to isoflurane. Isoflurane significantly (P < 0.05) reduced infarct size (22 +/- 3% of the left ventricular area at risk) as compared with control (39 +/- 2%). Celecoxib alone had no effect on infarct size (36 +/- 4%) but abolished isoflurane-induced cardioprotection (36 +/- 4%). A single dose of celecoxib administered 2.5 h before coronary occlusion and reperfusion also abolished the delayed protective effects of isoflurane (36 +/- 4%), but celecoxib given 30 min before exposure to isoflurane had no effect (22 +/- 4%). Isoflurane did not alter COX-1 and COX-2 protein expression. The results indicate that the volatile anesthetic isoflurane produces a second window of preconditioning against myocardial ischemia and reperfusion injury. Furthermore, COX-2 is an important mediator of isoflurane-induced delayed preconditioning.

キーワード 推奨
  1. (英) Anesthetics, Inhalation
  2. (英) Animals
  3. (英) Blood Pressure
  4. (英) Blotting, Western
  5. (英) Coronary Circulation
  6. (英) Cyclooxygenase 1
  7. (英) Cyclooxygenase 2
  8. (英) Cyclooxygenase 2 Inhibitors
  9. (英) Cyclooxygenase Inhibitors
  10. (英) Heart Rate
  11. (英) Ischemic Preconditioning, Myocardial
  12. (英) Isoenzymes
  13. (英) Isoflurane
  14. (英) Male
  15. (英) Myocardial Infarction
  16. (英) Myocardial Ischemia
  17. (英) Myocardial Reperfusion Injury
  18. (英) Prostaglandin-Endoperoxide Synthases
  19. (英) Pyrazoles
  20. (英) Rabbits
  21. (英) Sulfonamides
  22. (英) Ventricular Function, Left
発行所 推奨 The American Society of Anesthesiologists
誌名 必須 Anesthesiology([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)
ISSN 任意 0003-3022
ISSN: 0003-3022 (pISSN: 0003-3022, eISSN: 1528-1175)
Title: Anesthesiology
Title(ISO): Anesthesiology
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 100
必須 3
必須 525 531
都市 任意
年月日 必須 2004年 3月 初日
URL 任意
DOI 任意 10.1097/00000542-200403000-00010    (→Scopusで検索)
PMID 任意 15108964    (→Scopusで検索)
NAID 任意
WOS 任意 000189251700009
Scopus 任意
評価値 任意
被引用数 任意 13
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA.

  2. (英) Article.PublicationTypeList.PublicationType: In Vitro

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.