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著作: [田中 克哉]/Weihrauch D/Ludwig LM/Kersten JR/Pagel PS/Warltier DC/Mitochondrial adenosine triphosphate-regulated potassium channel opening acts as a trigger for isoflurane-induced preconditioning by generating reactive oxygen species./[Anesthesiology]

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EID
94649
EOID
691851
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0
LastModified
2013年6月21日(金) 16:30:43
Operator
大家 隆弘
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Owner
田中 克哉
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. Medical College of Wisconsin
著者 必須
  1. 田中 克哉([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Weihrauch D
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Ludwig LM
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Kersten JR
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Pagel PS
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Warltier DC
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Mitochondrial adenosine triphosphate-regulated potassium channel opening acts as a trigger for isoflurane-induced preconditioning by generating reactive oxygen species.

副題 任意
要約 任意

(英) Whether the opening of mitochondrial adenosine triphosphate-regulated potassium (K(ATP)) channels is a trigger or an end effector of anesthetic-induced preconditioning is unknown. We tested the hypothesis that the opening of mitochondrial K(ATP) channels triggers isoflurane-induced preconditioning by generating reactive oxygen species (ROS) in vivo. Pentobarbital-anesthetized rabbits were subjected to a 30-min coronary artery occlusion followed by 3 h reperfusion. Rabbits were randomly assigned to receive a vehicle (0.9% saline) or the selective mitochondrial K(ATP) channel blocker 5-hydroxydecanoate (5-HD) alone 10 min before or immediately after a 30-min exposure to 1.0 minimum alveolar concentration (MAC) isoflurane. In another series of experiments, the fluorescent probe dihydroethidium was used to assess superoxide anion production during administration of 5-HD or the ROS scavengers N-acetylcysteine or N-2-mercaptopropionyl glycine (2-MPG) in the presence or absence of 1.0 MAC isoflurane. Myocardial infarct size and superoxide anion production were measured using triphenyltetrazolium staining and confocal fluorescence microscopy, respectively. Isoflurane (P < 0.05) decreased infarct size to 19 +/- 3% (mean +/- SEM) of the left ventricular area at risk as compared to the control (38 +/- 4%). 5-HD administered before but not after isoflurane abolished this beneficial effect (37 +/- 4% as compared to 24 +/- 3%). 5-HD alone had no effect on infarct size (42 +/- 3%). Isoflurane increased fluorescence intensity. Pretreatment with N-acetylcysteine, 2-MPG, or 5-HD before isoflurane abolished increases in fluorescence, but administration of 5-HD after isoflurane only partially attenuated increases in fluorescence produced by the volatile anesthetic agent. The results indicate that mitochondrial K(ATP) channel opening acts as a trigger for isoflurane-induced preconditioning by generating ROS in vivo.

キーワード 推奨
  1. (英) Adenosine Triphosphatases
  2. (英) Anesthetics, Inhalation
  3. (英) Animals
  4. (英) Ethidium
  5. (英) Fluorescent Dyes
  6. (英) Free Radical Scavengers
  7. (英) Hemodynamics
  8. (英) Ion Channel Gating
  9. (英) Ischemic Preconditioning, Myocardial
  10. (英) Isoflurane
  11. (英) Male
  12. (英) Microscopy, Confocal
  13. (英) Mitochondria, Heart
  14. (英) Myocardial Infarction
  15. (英) Myocardium
  16. (英) Potassium Channels
  17. (英) Pulmonary Alveoli
  18. (英) Rabbits
  19. (英) Reactive Oxygen Species
発行所 推奨 The American Society of Anesthesiologists
誌名 必須 Anesthesiology([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)
ISSN 任意 0003-3022
ISSN: 0003-3022 (pISSN: 0003-3022, eISSN: 1528-1175)
Title: Anesthesiology
Title(ISO): Anesthesiology
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 98
必須 4
必須 935 43
都市 任意
年月日 必須 2003年 4月 初日
URL 任意 http://ci.nii.ac.jp/naid/30009128458/
DOI 任意 10.1097/00000542-200304000-00021    (→Scopusで検索)
PMID 任意 12657856    (→Scopusで検索)
NAID 任意 30009128458
WOS 任意 000181865500020
Scopus 任意
評価値 任意
被引用数 任意 4
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.