徳島大学 教育・研究者情報データベース(EDB)

1. (英) Matsunaga Hiroko

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2. 本田 浩仁

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3. (英) Kubo Kenichiro

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4. (英) Sannomiya Katsutaka

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5. (英) Cui Xuezhi

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6. (英) Toyota Yoshio

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7. (英) Mori Toshifumi

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8. 六車 直樹

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9. 岡久 稔也([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域総合医療学]/[徳島大学.病院.診療科.内科.消化器内科])

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10. 岡村 誠介

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11. 清水 一郎

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12. 伊東 進

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(英) Clinical value of the determination of serum guanase activity in patients with chronic hepatitis type C

(英) The study examines the clinical significance of guanase (GU) measurement in patients with hepatitis C. 688 patients in whom either ALT was abnormal, or in whom HBsAg or HCVAb was detected in the serum, were enrolled into this study. The percentage of cases in which normal ALT while elevated GU was compared among the different disease groups. Then, the percentage of cases with normal ALT but elevated GU was compared between HBV and HCV groups. For the entire population, a significant correlation was observed between ALT and GU (r=0.872). The overall percentage of cases with normal ALT but elevated GU activity was 11.4%. In HCV group, 449 cases had normal ALT. Of these cases, 20.3% had elevated GU, while ALT was normal. Before 1989, no test to check donated blood for HCV antibody was available. However, screening of donated blood for high GU was associated with a reduced incidence of post-transfusion hepatitis. This is probably because following the screening, blood donated by patients with hepatitis C who had normal ALT but elevated GU was rejected. After the introduction of HCV antibody measurement, GU measurement is still useful to reveal the pathophysiological condition in-patients with chronic hepatitis type C.

1. (英) Alanine Transaminase
2. (英) Biological Markers
3. (英) Blood Donors
4. (英) Comorbidity
5. (英) Guanine Deaminase
6. (英) Hepatitis B Surface Antigens
7. (英) Hepatitis B, Chronic
8. (英) Hepatitis C Antibodies
9. (英) Hepatitis C, Chronic
10. (英) Humans
11. (英) Incidence
12. (英) Japan
13. (英) Mass Screening
14. (英) Prospective Studies
15. (英) Sensitivity and Specificity

1. (英) Article.Affiliation: Second Department of Internal Medicine, The University of Tokushima School of Medicine, Tokushima, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Evaluation Studies

3. (英) Article.PublicationTypeList.PublicationType: Journal Article