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著作: Takashi Ban/Masao Kojima/Hideaki Sada/[大下 修造]/Effects of prenylamine on transmembrane action potentials as related to the change in external potassium concentrations in guinea pig papillary muscle/[Journal of Cardiovascular Pharmacology]

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EID
94063
EOID
936773
Map
0
LastModified
2018年12月17日(月) 14:54:05
Operator
三木 ちひろ
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大下 修造
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Takashi Ban
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Masao Kojima
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Hideaki Sada
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 大下 修造
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Effects of prenylamine on transmembrane action potentials as related to the change in external potassium concentrations in guinea pig papillary muscle

副題 任意
要約 任意

(英) We studied the effects of 4.8 muM prenylamine on transmembrane potentials in isolated guinea pig papillary muscles using a conventional microelectrode technique and compared them with those of 36.9 microM lidocaine. Prenylamine reduced Vmax at 1 Hz increasingly as the external potassium, [K]o, was increased from 2.7 to 10 mM. The reduction was also increased as the driving rate was increased from 0.25 to 5 Hz. The rate-dependent depression was less in 2.7 and 8.1 mM with 7.2 mM [Ca]o and more in 5.4 and 8.1 mM [K]o with 1.8 mM [Ca]o. Prenylamine produced a marked delay in the recovery of Vmax in premature responses inserted between constant driving stimuli at 0.25 Hz. The delay was also less in the former two, and more in the latter two media. Thus the effects of prenylamine on Vmax were more rate dependent and less [K]o-dependent than those of 36.9 microM lidocaine. At the diastolic interval of 100 ms, prenylamine depressed the overshoot, action potential duration at 0 mV level (APDo) and Vmax in premature responses more markedly than did 36.9 microM lidocaine, the differences of the effects being more significant for the first two. The results are interpreted as representing the calcium-antagonistic property of prenylamine of which lidocaine appears to be devoid.

キーワード 推奨
  1. (英) Action Potentials
  2. (英) Animals
  3. (英) Electric Stimulation
  4. (英) Female
  5. (英) Guinea Pigs
  6. 心臓(heart)
  7. (英) In Vitro Techniques
  8. (英) Kinetics
  9. (英) Male
  10. 心筋(myocardium)
  11. (英) Papillary Muscles
  12. カリウム(potassium)
  13. (英) Prenylamine
発行所 推奨
誌名 必須 Journal of Cardiovascular Pharmacology([Lippincott Williams & Wilkins])
(pISSN: 0160-2446, eISSN: 1533-4023)
ISSN 任意 0160-2446
ISSN: 0160-2446 (pISSN: 0160-2446, eISSN: 1533-4023)
Title: Journal of cardiovascular pharmacology
Title(ISO): J Cardiovasc Pharmacol
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 4
必須 4
必須 601 608
都市 任意
年月日 必須 1982年 0月 初日
URL 任意
DOI 任意
PMID 任意 6181334    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article

  2. (英) MedlineDate: 1982 Jul-Aug