著作: [坂田 ひろみ]/[澤田 和彦]/[崔 春]/[太田 恭子]/[福井 義浩]/Adverse effects of maternal ethanol consumption on development of dorsal hippocampus in rat offspring./[Acta Neuropathologica]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | Peer Review | |||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Adverse effects of maternal ethanol consumption on development of dorsal hippocampus in rat offspring. |
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副題 | 任意 | ||||
要約 | 任意 |
(英) We examined the laminar structure and distribution of mossy fiber terminal fields in the dorsal hippocampus, an important area for spatial learning, in rats exposed to ethanol during gestational days 10-21. Pyramidal cells in the CA3a subfield were loosely packed compared to control rats. Aberrant infra- and intrapyramidal mossy fibers were found in the CA3 region, especially in the CA3a subfield, throughout the dorsal hippocampus of ethanol-exposed rats. Aberrant mossy fiber terminals were observed more frequently in the rostral than the caudal level of the dorsal hippocampus. At the most caudal level of the dorsal hippocampus, disarrangement of pyramidal cells was seen in the CA3c subfield along with disturbed mossy fiber terminals. Immunohistochemical studies revealed that neural cell adhesion molecule (NCAM) was not related to aberrant distribution of mossy fiber terminals after prenatal exposure to ethanol. Parvalbumin immunoreactivity was increased in the dorsal hippocampus of ethanol-exposed rats compared with control rats. Abnormal development of the dorsal hippocampus induced by prenatal ethanol exposure may be associated with the defect of spatial memory seen in fetal alcohol syndrome children and their animal models. |
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キーワード | 推奨 | ||||
発行所 | 推奨 | Springer-Verlag | |||
誌名 | 必須 |
Acta Neuropathologica(World Federation of Neurology)
(pISSN: 0001-6322, eISSN: 1432-0533)
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巻 | 必須 | 105 | |||
号 | 必須 | 1 | |||
頁 | 必須 | 30 36 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2003年 5月 初日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.1007/s00401-002-0606-9 (→Scopusで検索) | |||
PMID | 任意 | 12471458 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | 000179992500005 | |||
Scopus | 任意 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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