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著作: [石村 和敬]/Fujita Hisao/Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes./[Microscopy Research and Technique]

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EID
92074
EOID
771143
Map
0
LastModified
2015年3月24日(火) 16:30:29
Operator
三木 ちひろ
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TRUE
Censor
0
Owner
[副研究部長]/[大学院ヘルスバイオサイエンス研究部]
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種別 必須 総説·解説
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 大学院ヘルスバイオサイエンス研究部.神経情報医学部門.情報統合医学講座(2004年4月1日〜)
著者 必須
  1. 石村 和敬
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Fujita Hisao
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes.

副題 任意
要約 任意

(英) Recent immunohistochemical studies have revealed the precise localization of the enzymes involved in adrenal steroidogenesis. Light microscopical investigations showed that cytochromes P450 of cholesterol side-chain cleavage enzyme (P450scc) and of 11 beta-hydroxylase (P45011 beta), 3 beta-hydroxysteroid dehydrogenase/ delta 5-4 isomerase (3 beta HSD), and 21-hydroxylase (P450C21) are localized in all the adrenocortical cells, especially in those of the zona fasciculata-reticularis. 17 alpha-Hydroxylase/C17-C20 lyase (P45017 alpha,lyase) is present in the zona fasciculata-reticularis cells of human, bovine, pig, and guinea-pig adrenals, but absent in the adrenals of some rodents such as rat, hamster, and mouse. Aldosterone synthase (P450aldo) is contained only in the zona glomerulosa cells. In the rat adrenal, P45011 beta, which catalyzes the conversion of deoxycorticosterone to corticosterone, is localized in the zona fasciculata-reticularis cells. Electron microscopic investigations demonstrated that P450scc and P45011 beta are colocalized in the matrix side of inner mitochondrial membrane including cristae, while 3 beta HSD, P450C21, and P45017 alpha, lyase are present in the membranes of smooth endoplasmic reticulum (SER). These results clearly indicate that aldosterone, the most potent mineralocorticoid, is synthesized in the zona glomerulosa cells, and glucocorticoids, such as corticosterone and cortisol, are produced in the zona fasciculata-reticularis cells. The conversion of cholesterol to pregnenolone and the final steps of corticosteroid synthesis occur in the mitochondria, while the intermediate steps, leading to the synthesis of deoxycorticosterone or deoxycortisol from pregnenolone, take place in the SER membranes.

キーワード 推奨
  1. (英) 3-Hydroxysteroid Dehydrogenases
  2. (英) Adrenal Cortex Hormones
  3. (英) Animals
  4. (英) Cattle
  5. (英) Cytochrome P-450 Enzyme System
  6. (英) Embryonic and Fetal Development
  7. (英) Humans
  8. 免疫組織化学(immunohistochemistry)
  9. (英) Microscopy, Immunoelectron
  10. (英) Rats
  11. (英) Steroid 11-beta-Hydroxylase
  12. (英) Steroids
発行所 推奨
誌名 必須 Microscopy Research and Technique([Wiley Periodicals, Inc.])
(pISSN: 1059-910X, eISSN: 1097-0029)
ISSN 任意 1059-910X
ISSN: 1059-910X (pISSN: 1059-910X, eISSN: 1097-0029)
Title: Microscopy research and technique
Title(ISO): Microsc Res Tech
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 36
必須 6
必須 445 453
都市 任意
年月日 必須 1997年 3月 15日
URL 任意
DOI 任意 10.1002/(SICI)1097-0029(19970315)36:6<445::AID-JEMT2>3.0.CO;2-H    (→Scopusで検索)
PMID 任意 9142691    (→Scopusで検索)
NAID 任意
WOS 任意 A1997WX01000002
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Anatomy, Tokushima University, School of Medicine, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Review

  4. (英) NumberOfReferences: 76