徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.医学部.医学科.病態情報医学講座
2. 徳島大学.医学部.附属病院(〜2003年9月30日/->組織[徳島大学.病院.医科診療部門])

1. 野﨑 淳平

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2. 北畑 洋

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3. 田中 克哉([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])

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4. 川人 伸次([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])

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5. 大下 修造

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(英) The effects of acute normovolemic hemodilution on left ventricular systolic and diastolic function in the absence or presence of beta-adrenergic blockade in dogs.

(英) Acute normovolemic hemodilution (ANH) increases cardiac output because of a reduction in blood viscosity and enhancement of left ventricular (LV) contractility. The status of LV function, especially LV diastolic function during ANH, remains controversial. We therefore examined LV systolic and diastolic function during ANH. Sixteen dogs were anesthetized with isoflurane in the absence (Group 1) and presence (Group 2) of beta-adrenergic blockade (propranolol 1 mg/kg). LV contractility was quantified by the slope (M(w)) of the stroke work and end-diastolic volume relation. Diastolic function was evaluated with the time constant of LV relaxation (T), chamber stiffness constant (K(c)), peak LV diastolic filling rate during early filling (peak E) and atrial contraction (peak A), and ratio of peak E to peak A (E/A). Normovolemic exchange of blood (50 mL/kg) for 6% hydroxyethyl starch (ANH50) significantly increased M(w) in Group 1 but not in Group 2. In both groups, ANH50 significantly decreased T. ANH50 significantly increased peak E in both groups and peak A in Group 1, and it did not change the E/A ratio or K(c) in either group. ANH causes positive inotropic effects and enhances diastolic function without beta-blockade. Even after beta-adrenergic blockade, ANH improves diastolic function through the reduction of LV ejection impedance. IMPLICATIONS: Acute normovolemic hemodilution enhances LV (left ventricular) diastolic function by alterations in the LV loading condition produced by hemodilution, which mainly contributes to a compensatory increase in cardiac output.

1. (英) PRESSURE-VOLUME RELATIONSHIPS
2. (英) MYOCARDIAL RELAXATION
3. (英) PRELOAD
4. (英) CONTRACTILITY
5. (英) DESFLURANE
6. (英) ISOFLURANE
7. (英) HALOTHANE
8. (英) CATHETER
9. (英) INDEXES
10. (英) HUMANS

1. (英) Article.Affiliation: Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan. jnozaki@clin.med.tokushima-u.ac.jp

2. (英) Article.PublicationTypeList.PublicationType: Journal Article