徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.医学部.医学科.病態情報医学講座
2. 徳島大学.医学部.附属病院(〜2003年9月30日/->組織[徳島大学.病院.医科診療部門])

1. 野﨑 淳平

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2. 北畑 洋

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3. 田中 克哉([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])

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4. 川人 伸次([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])

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5. 大下 修造

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(英) Effects of acute normovolemic hemodilution on ventriculoarterial coupling in dogs.

(英) Acute normovolemic hemodilution (ANH) causes a decrease in systemic vascular resistance. Similar to vasodilating drugs, ANH might modify ventriculoarterial coupling. Left ventricular elastance (Ees), effective arterial elastance (Ea), stroke work (SW), and pressure volume area (PVA) were used as indicators to examine the effects of ANH on this coupling. After institutional approval eight dogs were anesthetized with isoflurane and subjected to measurements including aortic pressure, left ventricular (LV) pressure, and LV volume. Left ventricular volume was measured with a conductance catheter. Ees was determined as the slope of the end-systolic pressure-volume relationship. Ea was determined as the ratio of LV end-systolic pressure to stroke volume. Ventriculoarterial coupling was evaluated as the ratio of Ees to Ea. Mechanical efficiency, another criterion for ventriculoarterial coupling, was calculated as the ratio of SW to PVA. Data are expressed as mean+/-SD, and P<0.05 was considered significant. Normovolemic exchange of 50 ml kg-1 of blood for 6% hydroxyethyl starch (ANH50) reduced hemoglobin concentration from 12.8+/-3.0 g dl-1 to 6.4+/-1.3 g dl-1. Acute normovolemic hemodilution 50 did not change Ees significantly although it significantly decreased Ea. Left ventricular elastance/Ea did not change after ANH (1.0+/-0.4 at baseline and 1.2+/-0.5 at ANH50). Acute normovolemic hemodilution 50 significantly increased SW and PVA, preventing SW/PVA from changing significantly after ANH (0.57+/-0.10 at baseline and 0.62+/-0.14 at ANH50). Before ANH, ventriculoarterial coupling was so matched as to maximize SW at the expense of the work efficiency. This relation was preserved at ANH50.

1. (英) Algorithms
2. (英) Anesthesia
3. (英) Animals
4. (英) Arteries
5. (英) Blood Gas Analysis
6. (英) Blood Pressure
7. (英) Blood Volume
8. (英) Dogs
9. (英) Elasticity
10. (英) Female
11. (英) Heart
12. (英) Hemodilution
13. (英) Male
14. (英) Stroke Volume
15. (英) Ventricular Function
16. (英) Ventricular Function, Left

1. (英) Article.Affiliation: Department of Anesthesiology, Tokushima University School of Medicine, Japan. jnozaki@clin.med.tokushima-u.ac.jp

2. (英) Article.PublicationTypeList.PublicationType: Journal Article