徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.医学部.医学科.病態情報医学講座
2. 徳島大学.病院.診療科.脳·神経·精神科(2003年10月1日〜)
3. 徳島大学.病院.中央診療施設等.手術部(2003年10月1日〜)

1. 田中 克哉([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])

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2. 北畑 洋

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3. 川人 伸次([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])

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4. 野﨑 淳平

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5. 富山 芳信([徳島大学.病院.中央診療施設等.手術部])

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6. 大下 修造

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(英) Phenylephrine increases pulmonary blood flow in children with tetralogy of Fallot.

(英) Although it has been reported that the increase in blood pressure improves arterial oxygen saturation (SaO(2)) in children with tetralogy of Fallot, no prospective study has demonstrated that an increase in blood pressure induces an increase in pulmonary blood flow in these patients. The purpose of this study was to see whether a phenylephrine-induced increase in systemic blood pressure increased pulmonary blood flow, resulting in improved arterial oxygenation in tetralogy of Fallot. In 14 consecutive children with tetralogy of Fallot (2-32 months old), transesophageal pulsed Doppler signals of left upper pulmonary venous flow (PVF) velocity were recorded before and four minutes after 10 micro g x kg(-1) of phenylephrine i.v. Simultaneously, arterial blood gas analysis and hemodynamic measurements were performed. The minute distance (MD) was calculated as the product of the heart rate and the sum of time-velocity integrals of PVF. Phenylephrine iv increased mean arterial blood pressure from 54 +/- 8 mmHg to 73 +/- 10 mmHg. This phenylephrine-induced hypertension significantly increased SaO(2) and MD (92.0 +/- 7.5 vs 95.0 +/- 5.0% and 1318 +/- 344 vs 1533 +/- 425 cm x min(-1), respectively). There was a significant correlation (r = 0.72) between the change in MD and the change in SaO(2). Our results suggest that the phenylephrine-induced increase in systemic blood pressure produces an increase in pulmonary blood flow in tetralogy of Fallot. Our results further suggest that this increase in pulmonary blood flow is involved in the mechanism of phenylephrine-induced improvement of arterial oxygenation in tetralogy of Fallot.

1. (英) Blood Flow Velocity
2. (英) Blood Gas Analysis
3. 子ども(children)
4. (英) Child, Preschool
5. (英) Echocardiography, Doppler, Pulsed
6. 経食道心エコー(transesophageal echocardiography)
7. (英) Female
8. (英) Hemodynamics
9. (英) Humans
10. (英) Hypertension
11. 小児(infant)
12. (英) Male
13. (英) Oxygen
14. (英) Phenylephrine
15. (英) Pulmonary Circulation
16. (英) Pulmonary Veins
17. (英) Tetralogy of Fallot
18. (英) Vasoconstrictor Agents

1. (英) Article.Affiliation: Department of Anaesthesiology, Tokushima University School of Medicine, Tokushima, Japan. ktanaka@mcw.edu

2. (英) Article.PublicationTypeList.PublicationType: Clinical Trial

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't