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著作: [森田 恭二]/[有持 秀喜]/[大西 克成]/In vitro cytotoxicity of 4-methylcatechol in murine tumor cells: Induction of apoptotic cell death by extracellular pro-oxidant action/[The Journal of Pharmacology and Experimental Therapeutics]

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EID
90283
EOID
691554
Map
0
LastModified
2013年6月19日(水) 17:07:18
Operator
大家 隆弘
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Owner
有持 秀喜
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 森田 恭二
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 有持 秀喜([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 大西 克成
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) In vitro cytotoxicity of 4-methylcatechol in murine tumor cells: Induction of apoptotic cell death by extracellular pro-oxidant action

副題 任意
要約 任意

(英) Assessment of the in vitro cytotoxicity has recently been become popular as a primary screening method for evaluating the antitumor activities of various chemicals and natural substances. For example, quercetin and related phenolic compounds, present in teas, wines, and other plant products, have been shown to cause their cytotoxic effects on tumor cells in culture, proposing their protective effects against the development of cancer. However, 4-methylcatechol, a metabolite produced in the intestinal tract after ingestion, has been shown to cause the promotion rather than suppression of tumor in rat stomach despite its in vitro cytotoxic activity. To address the inconsistency between its in vivo and in vitro actions, the effect of 4-methylcatechol on the viabilities of murine tumor cells was examined, and 4-methylcatechol was shown to reduce their viabilities through the induction of apoptosis. In addition, since catechol compounds have been shown to have a complex mixture of pro-oxidant and antioxidant actions in the in vitro assay systems, the cytotoxic activity of 4-methylcatechol was reassessed in the presence of either catalase or reduced-form glutathione, and both of them were shown to protect the cells against the damage induced by 4-methylcatechol. Moreover, the generation of hydrogen peroxide was observed by incubating the drug in the growth medium with or without the cells. These findings indicate that, similar to other catechol compounds, 4-methylcatechol may induce the apoptotic death of murine tumor cells through its extracellular pro-oxidant action on the cells.

キーワード 推奨
  1. (英) Animals
  2. (英) Apoptosis
    データベース中に適合する可能性のある以下の情報を発見しました
    [キーワード] アポトーシス (apoptosis)
  3. (英) Catechols
  4. (英) Cell Death
    データベース中に適合する可能性のある以下の情報を発見しました
    [キーワード] 細胞死 (cell death)
  5. (英) Cell Survival
  6. (英) Melanoma, Experimental
  7. (英) Mice
    データベース中に適合する可能性のある以下の情報を発見しました
    [キーワード] ノックアウトマウス (knockout mice)
  8. (英) Oxidants
  9. (英) Tumor Cells, Cultured
発行所 推奨
誌名 必須 The Journal of Pharmacology and Experimental Therapeutics(American Society for Pharmacology and Experimental Therapeutics)
(pISSN: 0022-3565, eISSN: 1521-0103)
ISSN 任意 0022-3565
ISSN: 0022-3565 (pISSN: 0022-3565, eISSN: 1521-0103)
Title: The Journal of pharmacology and experimental therapeutics
Title(ISO): J. Pharmacol. Exp. Ther.
Publisher: American Society for Pharmacology and Experimental Therapeutics
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 306
必須 1
必須 317 323
都市 任意
年月日 必須 2003年 4月 3日
URL 任意
DOI 任意 10.1124/jpet.103.050351    (→Scopusで検索)
PMID 任意 12676882    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Pharmacology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. km@basic.med.tokushima-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article