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著作: [森田 恭二]/[有持 秀喜]/鶴尾 吉宏/Adrenergic activation of steroid 5a-reductase gene expression in rat C6 glioma cells: Involvement of cyclic AMP/protein kinase A-mediated signaling pathway/[Journal of Molecular Neuroscience : MN]

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EID
90267
EOID
730889
Map
0
LastModified
2014年4月16日(水) 15:50:22
Operator
松井 栄里
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Owner
有持 秀喜
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
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共著種別 推奨
学究種別 推奨
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著者 必須
  1. 森田 恭二
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 有持 秀喜([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Tsuruo Yoshihiro / (日) 鶴尾 吉宏
    データベース中に適合する可能性のある以下の情報を発見しました
    [個人] 鶴尾 吉宏 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.顕微解剖学])
    この情報が上記に掲げた個人の業績等に分類されるためには参照登録が必要です.上記に掲げた個人本人に該当する場合には参照登録に変更してください.
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Adrenergic activation of steroid 5a-reductase gene expression in rat C6 glioma cells: Involvement of cyclic AMP/protein kinase A-mediated signaling pathway

副題 任意
要約 任意

(英) Steroid 5alpha-reductase (5alpha-R) is well known as the enzyme converting progesterone and other steroid hormones to their 5alpha-reduced metabolites and has been reported to be localized in both neuronal and glial cells in the brain. Previously, the enzyme activity in glial cells has been shown to be enhanced either by coculturing with neuronal cells or by adding the conditioned medium of neuronal cells, suggesting a possible implication of neuro-glial interactions in the regulation of neurosteroid metabolism in the brain. In the present studies, the effects of adrenergic agonists on 5alpha-R mRNA and protein levels in rat C6 glioma cells were examined as one of the model experiments for investigating the influence of neuronal activity on the expression of 5alpha-R gene in the glial cell. The direct challenge of beta-adrenergic agonists to glioma cells resulted in the rapid and transient elevation of 5alpha-R mRNA levels through the activation of the cyclic AMP (cAMP)/protein kinase A-mediated signaling pathway. Further studies showed that cAMP-induced 5alpha-R mRNA expression was completely abolished by pretreatment of cells with actinomycin D and also indicated that the elevation of 5alpha-R mRNA levels was accompanied by an increase in enzyme protein in the cells. These findings provide strong evidence that the stimulation of beta-adrenergic receptors might induce the transcriptional activation of 5alpha-R gene expression in glial cells, proposing the possibility that neuronal activity might be involved in the production of neuroactive 5alpha-reduced steroids in the brain.

キーワード 推奨
  1. (英) 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
  2. (英) Adrenergic beta-Agonists
  3. (英) Animals
  4. (英) Catecholamines
  5. (英) Cell Communication
  6. (英) Cyclic AMP
  7. (英) Cyclic AMP-Dependent Protein Kinases
  8. (英) Dactinomycin
  9. (英) Gene Expression Regulation, Enzymologic
  10. (英) Glioma
  11. (英) Neuroglia
  12. (英) Neurons
  13. (英) RNA, Messenger
  14. (英) Rats
  15. (英) Receptors, Adrenergic, beta
  16. (英) Steroids
  17. (英) Transcriptional Activation
  18. (英) Tumor Cells, Cultured
発行所 推奨
誌名 必須 Journal of Molecular Neuroscience : MN([Springer-Verlag])
(pISSN: 0895-8696, eISSN: 1559-1166)
ISSN 任意 0895-8696
ISSN: 0895-8696 (pISSN: 0895-8696, eISSN: 1559-1166)
Title: Journal of molecular neuroscience : MN
Title(ISO): J. Mol. Neurosci.
Supplier: Springer Online Journal Archive
Publisher: Springer New York
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 22
必須 3
必須 205 212
都市 任意
年月日 必須 2004年 0月 初日
URL 任意
DOI 任意 10.1385/JMN:22:3:205    (→Scopusで検索)
PMID 任意 14997014    (→Scopusで検索)
NAID 任意
WOS 任意 000220312300006
Scopus 任意 2-s2.0-2942544169
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Pharmacology, Tokushima University Schoolof Medicine, Kuramoto, Tokushima 770-8503, Japan. km@basic.med.tokushima-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't