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著作: Her Song/[有持 秀喜]/[森田 恭二]/Nerve growth factor induces elevation of steroid 5alpha-reductase mRNA levels in rat C6 glioma cells through expression of transcription factor Egr-1/[Brain Research. Molecular Brain Research]

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EID
90260
EOID
656989
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LastModified
2012年9月2日(日) 19:24:42
Operator
大家 隆弘
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有持 秀喜
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Her Song
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 有持 秀喜([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 森田 恭二
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Nerve growth factor induces elevation of steroid 5alpha-reductase mRNA levels in rat C6 glioma cells through expression of transcription factor Egr-1

副題 任意
要約 任意

(英) Steroid 5alpha-reductase type 1 (5alpha-R), the enzyme converting progesterone and other steroid hormones to their 5alpha-reduced metabolites, has been shown to be localized in both neuronal and glial cells, and this enzyme in glial cells has previously been reported to be activated either by co-culturing with neuronal cells or by adding the conditioned medium of neuronal cells, thus suggesting that neuronal activity may be implicated in the regulation of neurosteroid metabolism in brain. In the present study, to investigate a potential role of neurotrophic factors in the mechanism regulating the production of neuroactive 5alpha-reduced steroid metabolites, the direct action of NGF on 5alpha-R gene expression was examined by measuring the steady-state levels of 5alpha-R mRNA levels in rat C6 glioma cells. Exposure of the glioma cells to NGF increased both 5alpha-R mRNA and its protein levels, and induced the transient elevation of Egr-1 mRNA levels prior to the expression of 5alpha-R mRNA in the cells. Furthermore, NGF failed to induce any significant elevation of 5alpha-R mRNA levels in the cells pretreated with Egr-1 antisense oligodeoxynucleotides. These findings indicate that NGF induces the elevation of 5alpha-R gene expression in the glioma cells through the expression of transcription factor Egr-1, proposing the possibility that NGF, and probably other neurotrophic factors as well, may play a potential role in the regulation of 5alpha-reduced steroid production as one of the factors mediating the intercellular communication between neuronal and glial cells in the brain.

キーワード 推奨
  1. (英) 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
  2. (英) Analysis of Variance
    データベース中に適合する可能性のある以下の情報を発見しました
    [キーワード] 分散分析 (analysis of variance)
  3. (英) Animals
  4. (英) Cell Line, Tumor
  5. (英) DNA, Single-Stranded
  6. (英) Drug Interactions
  7. (英) Enzyme Inhibitors
  8. (英) Gene Expression Regulation, Enzymologic
  9. (英) Glioma
  10. (英) Nerve Growth Factor
  11. (英) Oligodeoxyribonucleotides, Antisense
  12. (英) RNA, Messenger
  13. (英) Rats
  14. (英) Reverse Transcriptase Polymerase Chain Reaction
  15. (英) Time Factors
発行所 推奨
誌名 必須 Brain Research. Molecular Brain Research(Elsevier)
(pISSN: 0169-328X)
ISSN 任意 0169-328X
ISSN: 0169-328X (pISSN: 0169-328X)
Title: Brain research. Molecular brain research
Title(ISO): Brain Res. Mol. Brain Res.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 126
必須 2
必須 157 164
都市 任意
年月日 必須 2004年 7月 26日
URL 任意
DOI 任意 10.1016/j.molbrainres.2004.04.002    (→Scopusで検索)
PMID 任意 15249139    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5485, USA.

  2. (英) Article.PublicationTypeList.PublicationType: Comparative Study

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't