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著作: Muramatsu Yasuko/Kurosaki Rumiko/Watanabe Hijiri/Michimata Mari/Matsubara Mitsunobu/Imai Yutaka/[荒木 勉]/Expression of S-100 protein is related to neuronal damage in MPTP-treated mice/[Glia]

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2012年9月2日(日) 17:39:52
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大家 隆弘
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
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著者 必須
  1. (英) Muramatsu Yasuko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Kurosaki Rumiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Watanabe Hijiri
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Michimata Mari
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Matsubara Mitsunobu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Imai Yutaka
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 荒木 勉
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Expression of S-100 protein is related to neuronal damage in MPTP-treated mice

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(英) S-100beta is a calcium-binding protein expressed at high levels in brain and is known as a marker of brain damage. However, little is known about the role of S-100beta protein during neuronal damage caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To determine whether S-100beta protein is induced in glial cells after MPTP treatment, we investigated the expression of S-100 protein immunohistochemically, using MPTP-treated mice. We also examined the change of neurons and glial cells in mice after MPTP treatment. The present study shows that tyrosine hydroxylase (TH) immunoreactivity decreased gradually in the striatum and substantia nigra from 1 day after MPTP treatment. Thereafter, TH-immunopositive cells and fibers decreased in the striatum and substantia nigra at 3 days after MPTP treatment. In contrast, S-100-immunopositive cells and glial fibrillary acidic protein (GFAP)-immunopositive cells increased markedly in the striatum and substantia nigra at 3 days after MPTP treatment. Seven days after MPTP treatment, S-100-immunopositive cells decreased in the striatum and substantia nigra. However, the number of GFAP-immunopositive cells increased in these regions. In double-labeled immunostaining with anti-S-100 and anti-GFAP antibodies, S-100 immunoreactivity was observed only in the GFAP-positive astrocytes. These results provide evidence that astrocytic activation may play a role in the pathogenesis of MPTP-induced degeneration of dopaminergic neurons. Furthermore, the present study demonstrates that S-100 protein is expressed selectively by astrocytes, but not by microglia, after MPTP treatment. These results provide valuable information for the pathogenesis of the acute stage of Parkinson's disease.

キーワード 推奨
  1. (英) MPTP
  2. 免疫組織化学(immunohistochemistry)
  3. (英) S-100
  4. (英) dopaminergic system
  5. (英) astrocytes
  6. (英) mice
発行所 推奨 Wiley-Liss, Inc.
誌名 必須 Glia([Wiley Periodicals, Inc.])
(pISSN: 0894-1491, eISSN: 1098-1136)
ISSN 任意 0894-1491
ISSN: 0894-1491 (pISSN: 0894-1491, eISSN: 1098-1136)
Title: Glia
Title(ISO): Glia
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 42
必須 3
必須 307 311
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年月日 必須 2003年 3月 25日
URL 任意 http://www3.interscience.wiley.com/cgi-bin/abstract/104086206/ABSTRACT
DOI 任意 10.1002/glia.10225    (→Scopusで検索)
PMID 任意 12673835    (→Scopusで検索)
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  1. (英) Article.Affiliation: Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article