徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.生体防御腫瘍医学講座(2004年4月1日〜2015年3月31日)

1. 上原 久典([徳島大学.病院.診療科.病理診断科])

   役割	任意
   貢献度	任意
   学籍番号	推奨

(英) Angiogenesis of prostate cancer and antiangiogenic therapy

(英) Tumor-associated angiogenesis refers to the growth of new vessels toward and within the tumor. Several studies have revealed that increasing intratumoral microvessel density, a major of tumor-associated angiogenesis, correlates with greater aggressiveness of prostate cancer. Angiogenesis consists of multiple, sequential, and interdependent steps dependent on the local balance of proangiogenic and antiangiogenic molecules Many proangiogenic and antiangiogenic molecules have been demonstrated to regulate growth and metastasis of prostate cancer. As tumor-associated angiogenesis is a crucial step in the process of prostate cancer development, inhibition of tumor neovascularization, and/or destruction of tumor vasculature (antiangiogenic therapy) may maintain the tumors in a dormant state or, perhaps in combination with cytotoxic therapies, potentiate shrinkage of tumors. Recently, therapeutic agents targeting the receptors of proangiogenic molecules and their signal transduction cascade have been developed. In this article, the role of angiogenic molecules in prostate cancer biology, and the application of angiogenesis inhibition to therapeutics for prostate cancer are reviewed.

1. (英) Angiogenic Proteins
2. (英) Drug Design
3. (英) Endostatins
4. (英) Humans
5. (英) Interferons
6. (英) Male
7. (英) Neovascularization, Pathologic
8. (英) Prostatic Neoplasms
9. (英) Signal Transduction

1. (英) Article.PublicationTypeList.PublicationType: Journal Article

2. (英) Article.PublicationTypeList.PublicationType: Review

3. (英) NumberOfReferences: 83