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著作: Hayashi H/Furihata M/Kuwahara M/[香川 征]/Shuin T/Ohtsuki Y/Infrequent Alteration in the p53R2 Gene in Human Transitional Cell Carcinoma of the Urinary Tract/[Pathobiology]

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EID
88229
EOID
656045
Map
0
LastModified
2012年8月30日(木) 16:04:07
Operator
大家 隆弘
Avail
TRUE
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Owner
香川 征
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
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著者 必須
  1. (英) Hayashi H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Furihata M
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Kuwahara M
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 香川 征
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Shuin T
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Ohtsuki Y
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Infrequent Alteration in the p53R2 Gene in Human Transitional Cell Carcinoma of the Urinary Tract

副題 任意
要約 任意

(英) Functional defects in DNA repair have been shown to be associated with genomic instability followed by cancer. Recently, p53R2 [p53-inducible ribonucleotide reductase (RR) small subunit 2 homologous] was identified as a novel RR gene which is directly regulated by p53 protein in the G1 and G2 phases of the cell cycle supplying nucleotides to repair damaged DNA. We performed genetic analyses of p53R2 to determine whether p53R2 alterations play significant roles in urothelial tumorigenesis. Genomic DNA from 108 primary transitional cell carcinomas (TCCs; 81 of the urinary bladder and 27 of the renal pelvis or ureter) was analyzed for mutation in the p53R2 gene by direct sequencing. We focused on three domains of the p53R2 gene: one RR small subunit signature involving codons 120-146 (region 1) and two putative nuclear localization signal sequences, involving codons 149-155 (region 2) and codons 163-169 (region 3). In addition, a p53-binding site of 20 nucleotides in intron 1 of p53R2 was also analyzed. One renal pelvic TCC (0.9%: 1/108) had a single-base substitution in p53R2 with a G to T transversion resulting in the amino acid substitution Glu136 --> Asp. This base substitution was localized within the domain of exon 4 encoding the RR small subunit signature, and causes an amino acid substitution in one of the most highly conserved regions of p53R2, in which human R2 and yeast RNR2 and RNR4 proteins are highly homologous. This finding provides the in vivo evidence for the infrequent involvement of alterations in p53R2 inhuman urothelial TCCs.

キーワード 推奨
  1. (英) Aged
  2. (英) Aged, 80 and over
  3. (英) Amino Acid Substitution
  4. (英) Base Sequence
  5. (英) Carcinoma, Transitional Cell
  6. (英) Cell Cycle Proteins
  7. (英) DNA, Neoplasm
  8. (英) Female
  9. (英) Humans
  10. (英) Male
  11. (英) Middle Aged
  12. (英) Molecular Sequence Data
  13. (英) Neoplasm Staging
  14. (英) Polymerase Chain Reaction
  15. (英) Ribonucleotide Reductases
  16. (英) Urologic Neoplasms
発行所 推奨
誌名 必須 Pathobiology(S. Karger AG, Basel)
(pISSN: 1015-2008, eISSN: 1423-0291)
ISSN 任意 1015-2008
ISSN: 1015-2008 (pISSN: 1015-2008, eISSN: 1423-0291)
Title: Pathobiology : journal of immunopathology, molecular and cellular biology
Title(ISO): Pathobiology
Publisher: S. Karger AG
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 71
必須 2
必須 103 106
都市 任意
年月日 必須 2004年 1月 初日
URL 任意
DOI 任意 10.1159/000074424    (→Scopusで検索)
PMID 任意 14707445    (→Scopusで検索)
NAID 任意
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Scopus 任意
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被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Division of Urology, Fujisaki Hospital, Saga, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't