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著作: [橋本 一郎]/[中西 秀樹]/Shono Yoshitaka/Toda Maki/Tsuda Hidetaka/[荒瀬 誠治]/Angiostatic effects of corticosteroid on wound healing of rabbit ear/[The Journal of Medical Investigation : JMI]

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EID
87418
EOID
878358
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LastModified
2017年12月4日(月) 14:06:44
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Owner
橋本 一郎
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種別 必須 学術論文(紀要その他)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 橋本 一郎([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.形成外科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 中西 秀樹
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Shono Yoshitaka
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Toda Maki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Tsuda Hidetaka
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 荒瀬 誠治
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Angiostatic effects of corticosteroid on wound healing of rabbit ear

副題 任意
要約 任意

(英) Wound healing is a complex biologic process with initial inflammation, granulation tissue formation, and matrix remodeling. We observed the relation between angiostatic effects and corticosteroid administration time in the rabbit ear chamber. Angiogenesis in the chamber was studied using a microscope-television system. Two experiments were undertaken to represent the systemic and the topical administration of steroids. In experiment 1, 10 mg of triamcinolone acetonide was injected three times intramuscularly (on the day of implantation of the chamber, and the 7th and 14th day after implantation). Vascularization in this group was significantly delayed at the 7th, 14th, and 21st days but no difference from controls was observed in the size and density of vessels after its completion. In experiment 2, 3 mg of triamcinolone acetonide was injected once into the skin adjacent to the chamber on the 10th day after installment of chambers or on the day of installment. In the former group, new vascular growth was delayed until the 21st day after installment. The hemorrhagic zone had narrowed and vascular dilation was observed. In the latter group, endothelial budding was delayed and vascular constriction occurred. New vascular growth was severely delayed and granulation filling of the chamber was not completed. These results suggest not only that the topical administration had the stronger inhibitory effect on neovascularization than the systemic administration but that the effect differed depending on the stage of wound healing. In view of this effect of this steroid, we should pay careful attention to the time when steroids are administered to patients.

キーワード 推奨
  1. (英) Adrenal Cortex Hormones
  2. (英) Angiogenesis Inhibitors
  3. (英) Animals
  4. (英) Anti-Inflammatory Agents
  5. (英) Ear
  6. (英) Injections, Intramuscular
  7. (英) Neovascularization, Physiologic
  8. (英) Rabbits
  9. (英) Triamcinolone Acetonide
  10. (英) Wound Healing
  11. (英) Wounds, Stab
発行所 推奨 (英) The University of Tokushima / (日) 徳島大学
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 49
必須 1,2
必須 61 66
都市 任意
年月日 必須 2002年 2月 初日
URL 任意 http://ci.nii.ac.jp/naid/110001901800/
DOI 任意
PMID 任意 11901762    (→Scopusで検索)
NAID 任意 110001901800
WOS 任意
Scopus 任意
機関リポジトリ 110637
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Plastic and Reconstructive Surgery, University of Tokushima School of Medicine, Kuramoto-cho, Tokushima 770-8503, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't