著作: [中西 正]/[清水 洋利]/[細川 義隆]/[松尾 敬志]/An immunohistological study on cyclooxygenase-2 in human dental pulp./[Journal of Endodontics]
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| 種別 | 必須 | 学術論文(審査論文) | |||
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| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | ||||
| カテゴリ | 推奨 | ||||
| 共著種別 | 推奨 | ||||
| 学究種別 | 推奨 | ||||
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| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) An immunohistological study on cyclooxygenase-2 in human dental pulp. |
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| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) Characteristics of cyclooxygenase-2 (COX-2) expressing cells in human dental pulp were immunohistologically studied. Extirpated pulpal tissues from extracted teeth were examined to elucidate the localization and distribution of COX-2. Pulpal tissues were examined by the labeled streptavidin biotin method using specific mouse monoclonal antibodies for COX-2. Cell types of the COX-2 expressing cells were also investigated by the double stain technique using both monoclonal antibodies for CD68/macrophage and anti-COX-2. COX-2 expressing cells could be found in all of the inflamed pulps, and these cells were mostly distributed close to the area of accumulation of inflammatory cells. COX-2 was mainly expressed in fibroblasts rather than macrophages. In contrast, COX-2 expressing cells were scarcely found in the normal pulps. These findings indicate that pulpal fibroblasts, as well as macrophages, may participate in the production of prostaglandin through COX-2 expression in pulpal inflammation, and might be involved in the pathogenesis of irreversible pulpitis. |
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| キーワード | 推奨 |
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| 発行所 | 推奨 | The American Association of Endodontics | |||
| 誌名 | 必須 |
Journal of Endodontics([The American Association of Endodontics])
(pISSN: 0099-2399, eISSN: 1878-3554)
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| 巻 | 必須 | 27 | |||
| 号 | 必須 | 6 | |||
| 頁 | 必須 | 385 388 | |||
| 都市 | 任意 | ||||
| 年月日 | 必須 | 2001年 6月 初日 | |||
| URL | 任意 | ||||
| DOI | 任意 | 10.1097/00004770-200106000-00003 (→Scopusで検索) | |||
| PMID | 任意 | 11487130 (→Scopusで検索) | |||
| CRID | 任意 | ||||
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| 指導教員 | 推奨 | ||||
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