徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.歯学部.歯学科.機能維持系臨床歯学講座.歯科保存学(〜2021年3月31日)

1. 中西 正([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.再生歯科治療学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])

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2. 清水 洋利([岡山大学])

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3. 細川 義隆([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])

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4. 松尾 敬志

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(英) An immunohistological study on cyclooxygenase-2 in human dental pulp.

(英) Characteristics of cyclooxygenase-2 (COX-2) expressing cells in human dental pulp were immunohistologically studied. Extirpated pulpal tissues from extracted teeth were examined to elucidate the localization and distribution of COX-2. Pulpal tissues were examined by the labeled streptavidin biotin method using specific mouse monoclonal antibodies for COX-2. Cell types of the COX-2 expressing cells were also investigated by the double stain technique using both monoclonal antibodies for CD68/macrophage and anti-COX-2. COX-2 expressing cells could be found in all of the inflamed pulps, and these cells were mostly distributed close to the area of accumulation of inflammatory cells. COX-2 was mainly expressed in fibroblasts rather than macrophages. In contrast, COX-2 expressing cells were scarcely found in the normal pulps. These findings indicate that pulpal fibroblasts, as well as macrophages, may participate in the production of prostaglandin through COX-2 expression in pulpal inflammation, and might be involved in the pathogenesis of irreversible pulpitis.

1. (英) Adult
2. (英) Antibodies, Monoclonal
3. (英) Antigens, CD
4. (英) Antigens, Differentiation, Myelomonocytic
5. (英) Coloring Agents
6. (英) Cyclooxygenase 2
7. (英) Dental Pulp
8. (英) Fibroblasts
9. (英) Fluorescent Dyes
10. (英) Humans
11. (英) Immunoenzyme Techniques
12. (英) Immunohistochemistry
13. (英) Isoenzymes
14. (英) Macrophages
15. (英) Membrane Proteins
16. (英) Middle Aged
17. (英) Peroxidases
18. (英) Prostaglandin-Endoperoxide Synthases
19. (英) Prostaglandins
20. (英) Pulpitis

1. (英) Article.PublicationTypeList.PublicationType: Journal Article

2. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't