徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.医学研究科
2. 徳島大学.歯学部.歯学科.発達育成系臨床歯学講座.口腔顎顔面矯正学

1. 松本 和也

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2. 中西 秀樹

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3. 久保 宜明([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.皮膚科学])

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4. 横関 雅彦

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5. 森山 啓司

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(英) Advances in distraction techniques for craniofacial surgery.

(英) Distraction osteogenesis has been applied to the craniofacial skeleton as well as the long bones of the extremities. This technique does not require bone grafting and allows correction of craniofacial deformities with less invasion. Moreover, the distraction procedures can expand the overlying soft tissues simultaneously. We determined the indications of distraction osteogenesis, analyzed the types of devices available, and examined patients treated with distraction for the mandible, midface, and cranium. In all three sites, the devices tended to be the buried type and made of absorbable materials. Administration of some cytokines for shortening the consolidation period may be considered. Among disorders indicated for distraction osteogenesis, there are several syndromic craniosynostoses, which involve mutations in the fibroblast growth factor receptor (FGFR) 2 gene. The FGFR 2 mutation was suggested to clinically accelerate osteogenesis at the distraction site. The usefulness and appropriateness of the distraction protocol must be assessed for each individual disorder. Although distraction osteogenesis in the craniofacial skeleton has advanced technologically, all possible risks must be discussed with the patient and family members when obtaining preoperative informed consent, especially until establishment of fully safe distraction procedures.

1. (英) Adult
2. (英) Child
3. (英) Craniofacial Abnormalities
4. (英) Craniosynostoses
5. (英) Female
6. (英) Humans
7. (英) Infant
8. (英) Male
9. (英) Mutation
10. (英) Osteogenesis, Distraction
11. (英) Receptor Protein-Tyrosine Kinases
12. (英) Receptor, Fibroblast Growth Factor, Type 2
13. (英) Receptors, Fibroblast Growth Factor
14. (英) Skull

1. (英) Article.Affiliation: Department of Plastic and Reconstructive Surgery, The University of Tokushima School of Medicine, Tokushima, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Case Reports

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) Article.PublicationTypeList.PublicationType: Review

5. (英) NumberOfReferences: 49