84731: Takahashi I/Nishimura M/Onodera K/Bae JW/Mitani H/[岡崎雅子]/Sasano Y/Mitani H/Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats./[Journal of Dental Research]

著作: Takahashi I/Nishimura M/Onodera K/Bae JW/Mitani H/[岡崎雅子]/Sasano Y/Mitani H/Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats./[Journal of Dental Research]

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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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Peer Review

カテゴリ

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共著種別

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学究種別

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組織

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著者

必須

(英) Takahashi I

役割任意

貢献度任意

学籍番号推奨
(英) Nishimura M

役割任意

貢献度任意

学籍番号推奨
(英) Onodera K

役割任意

貢献度任意

学籍番号推奨
(英) Bae JW

役割任意

貢献度任意

学籍番号推奨
(英) Mitani H

役割任意

貢献度任意

学籍番号推奨
岡崎雅子

役割任意

貢献度任意

学籍番号推奨
(英) Sasano Y

役割任意

貢献度任意

学籍番号推奨
(英) Mitani H

役割任意

貢献度任意

学籍番号推奨

題名

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(英) Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats.

副題

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要約

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(英) Periodontal ligament tissue is remodeled on both the tension and compression sides of moving teeth during orthodontic tooth movement. The present study was designed to clarify the hypothesis that the expression of MMP-8 and MMP-13 mRNA is promoted during the remodeling of periodontal ligament tissue in orthodontic tooth movement. We used the in situ hybridization method and semi-quantitative reverse-transcription/polymerase chain-reaction analysis to elucidate the gene expression of MMP-8 and MMP-13 mRNA. Expression of MMP-8 and MMP-13 mRNA transiently increased on both the compression and tension sides during active tooth movement in vivo. The gene expression of MMP-8 and MMP-13 was induced by tension, while compression indirectly promoted the gene expression of MMP-8 and MMP-13 through soluble factors in vitro. Thus, we concluded that the expression of MMP-8 and MMP-13 is differentially regulated by tension and compression, and plays an important role in the remodeling of the periodontal ligament.

キーワード

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(英) remodeling
コラーゲン(collagen)
(英) collagenase
(英) periodontal ligament

発行所

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誌名

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Journal of Dental Research([国際歯科研究学会])

(pISSN: 0022-0345, eISSN: 1544-0591)

ISSN	任意	0022-0345 ISSN: 0022-0345 (pISSN: 0022-0345, eISSN: 1544-0591) Title: Journal of dental research Title(ISO): J Dent Res Publisher: SAGE Publications (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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646 651

都市

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年月日

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2003年 8月 1日

URL

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http://ci.nii.ac.jp/naid/10015730796/

DOI

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10.1177/154405910308200815 (→Scopusで検索)

PMID

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12885852 (→Scopusで検索)

CRID

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1573387449965926528

NAID

10015730796

WOS

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000184432400015

Scopus

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評価値

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被引用数

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指導教員

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備考

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(英) Article.Affiliation: Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, Sendai, Japan. takahasi@mail.cc.tohoku.ac.jp
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

著作: Takahashi I/Nishimura M/Onodera K/Bae JW/Mitani H/[岡崎雅子]/Sasano Y/Mitani H/Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats./[Journal of Dental Research]

著作: Takahashi I/Nishimura M/Onodera K/Bae JW/Mitani H/[岡崎 雅子]/Sasano Y/Mitani H/Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats./[Journal of Dental Research]

著作: Takahashi I/Nishimura M/Onodera K/Bae JW/Mitani H/[岡崎雅子]/Sasano Y/Mitani H/Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats./[Journal of Dental Research]