徳島大学 教育・研究者情報データベース(EDB)

1. 佐藤 光信

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2. 岡本 正人

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3. (英) Ohe Go / (日) 大江 剛 / (読) おおえ ごう

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4. (英) Furuichi Sachiko / (日) 古市 幸子 / (読) ふるいち さちこ

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5. (英) Nishikawa Hidetomo / (日) 西川 英知 / (読) にしかわ ひでとも

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6. (英) Oshikawa Tetsuya / (日) 押川 哲也 / (読) おしかわ てつや

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7. (英) Tano Tomoyuki / (日) 田野 智之 / (読) たの ともゆき

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8. (英) Ahmed SU / (読) ショリフ ウディン アーメッド

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9. 吉田 秀夫

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(英) Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal agent, in athymic nude mice bearing human salivary adenocarcinoma: Role of natural killer cells

(英) OK-PSA, a lipoteichoic acid (LTA)-related molecule isolated from a streptococcal agent OK-432, enhances anti-tumor immunity as a potent inducer of Th1-type cytokines. Recently, we obtained the data suggesting that natural killer (NK) cells may play a significant role for OK-PSA-induced cytokine production in vitro. We conducted the animal experiments using athymic nude mice bearing human salivary adenocarcinoma to examine the role of NK cells in OK-PSA-induced anti-tumor immunity. OK-PSA was peritumorally injected into the mice. Cytokines in the sera were analyzed by ELISA. mRNAs for cytokines were detected by RT-PCR. 51Cr release test was performed to measure killer cell activities. OK-PSA markedly increased the amounts of IFN-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-2, IL-12 and IL-18 that are generally called "Th1-type cytokines" in the sera derived from tumor-bearing nude mice, and also accelerated the killing activities of tumor-infiltrating lymphocytes as well as of draining lymph node cells. Furthermore, OK-PSA administration resulted in significant inhibition of tumor growth, but the effect of OK-PSA was almost completely inhibited by the deletion of NK cells using anti-asialo GM1 antibody. These findings strongly suggested that NK cells are closely involved in OK-PSA-mediated anti-tumor immunity.

1. (英) Adenocarcinoma
2. (英) Animals
3. (英) Antibodies
4. (英) Cell Movement
5. (英) Combined Modality Therapy
6. 細胞質分裂(cytokinesis)
7. (英) G(M1) Ganglioside
8. (英) Humans
9. 免疫療法(immunotherapy)
10. (英) Killer Cells, Natural
11. (英) Lipopolysaccharides
12. (英) Lymphocytes
13. (英) Lymphocytes, Tumor-Infiltrating
14. (英) Male
15. (英) Mice
16. (英) Mice, Inbred BALB C
17. (英) Mice, Nude
18. 一酸化窒素(nitric oxide)
19. (英) Nitric Oxide Synthase
20. (英) Nitric Oxide Synthase Type II
21. (英) Picibanil
22. (英) RNA, Messenger
23. (英) Salivary Gland Neoplasms
24. (英) Teichoic Acids
25. (英) Th1 Cells
26. (英) Xenograft Model Antitumor Assays

1. (英) Article.Affiliation: Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, 3-18-15 Kuramoto-cho, Tokushima 7708504, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

4. (英) MedlineDate: 2002 Nov-Dec