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著作: Li, Chei Chiun/Xu, Bing/[廣川 満良]/[銭 志栄]/[吉本 勝彦]/[堀口 英久]/Wakatsuki, Shingo/Tashiro, Takashi/[佐野 壽昭]/Alterations of E-cadherin, a-catenin and b-catenin expression in neuroendocrine tumors of the gastrointestinal tract./[Virchows Archiv]

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EID
72265
EOID
876454
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0
LastModified
2017年11月28日(火) 17:52:50
Operator
大家 隆弘
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TRUE
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Owner
吉本 勝彦
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.医学部
著者 必須
  1. (英) Li, Chei Chiun
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Xu, Bing
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 廣川 満良
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 銭 志栄
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 吉本 勝彦
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 堀口 英久
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Wakatsuki, Shingo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Tashiro, Takashi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. 佐野 壽昭
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Alterations of E-cadherin, a-catenin and b-catenin expression in neuroendocrine tumors of the gastrointestinal tract.

副題 任意
要約 任意

(英) Neuroendocrine tumors (NETs) of the gastrointestinal tract comprise a heterogeneous group of neoplasms arising from the diffuse neuroendocrine system. These tumors strongly differ from each other on the basis of different pathogenetic, clinical, functional, histological, and prognostic patterns. Previous studies have shown that abnormal and reduced expression of the E-cadherin/catenin complex in several human cancers is associated with tumor dedifferentiation, advanced clinical stages, and poor survival rate. We assessed correlations between the expression of E-cadherin and catenins, Ki-67, and the following clinicopathological factors: age, embryological site of origin, size, histological growth pattern, the depth of penetration into the intestinal wall, and the presence of metastasis. In this study, reduction of membranous E-cadherin expression to a variable degree was detected in more than two-thirds (42 of 51) of gastrointestinal NETs (19 foregut, 8 midgut, and 24 hindgut) belonging to the complete neuroendocrine neoplastic spectrum [18 well-differentiated NETs, 22 well-differentiated neuroendocrine carcinomas (NECs), and 11 poorly differentiated NECs]. The reduction of E-cadherin expression was concomitant with the reduction of alpha-catenin (44 of 51) and beta-catenin (35 of 51) expression. Our immunohistochemical analysis demonstrated significant differences of percentage of membranous positive cells of E-cadherin, alpha-catenin, or beta-catenin between normal tissues and well-differentiated NETs (P=0.0038, P=0.004, and P=0.0329, respectively), well-differentiated NECs (P<0.001, P<0.001, and P<0.001, respectively) and poorly differentiated NECs (P=0.0002, P<0.0002, and P=0.0002, respectively). Among the gastrointestinal NETs, there were significantly more positive cells of E-cadherin, alpha-catenin, or beta-catenin in well-differentiated NETs than well-differentiated NECs (P=0.0006, P=0.0065, and P=0.0001, respectively) or poorly differentiated NECs (P=0.0053, P=0.0041, and P<0.001, respectively). MIB-1 labeling index generally showed a low proliferative activity in well-differentiated NETs (0.49+/-0.37) and well-differentiated NECs (0.662+/-0.66). A high proliferation rate was observed in poorly differentiated NECs (41.518+/-16.59). MIB-1 labeling index was significantly higher in poorly differentiated NECs than well-differentiated NETs and well-differentiated NECs (P<0.0001 and P<0.0001, respectively). E-cadherin, alpha-catenin, and beta-catenin expression were correlated significantly with transmural tumor invasion (P<0.0001, P=0.0001, and P<0.0001, respectively) and with size (P=0.0013, P=0.0001, and P<0.0001, respectively). These results indicate that the alteration in the E-cadherin/catenin expression may be involved in the growth and progression of gastrointestinal NETs.

キーワード 推奨
  1. (英) gastrointestinal neuroendocrine tumors
  2. (英) E-cadherin
  3. (英) alpha-catenin
  4. (英) beta-catenin
  5. (英) Ki-67
  6. 免疫組織化学(immunohistochemistry)
  7. (英) CARCINOID-TUMORS
  8. (英) HUMAN CANCERS
  9. (英) PROGNOSIS
  10. (英) PATHOGENESIS
  11. (英) PROGRESSION
  12. 転移(metastasis)
  13. 蛋白質(protein/->キーワード[タンパク質])
  14. (英) LESIONS
  15. (英) KI-67
  16. (英) APC
発行所 推奨
誌名 必須 Virchows Archiv(European Society of Pathology)
(pISSN: 0945-6317, eISSN: 1432-2307)
ISSN 任意 0945-6317
ISSN: 0945-6317 (pISSN: 0945-6317, eISSN: 1432-2307)
Title: Virchows Archiv : an international journal of pathology
Title(ISO): Virchows Arch
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 440
必須 2
必須 145 154
都市 任意
年月日 必須 2002年 1月 初日
URL 任意
DOI 任意 10.1007/s004280100529    (→Scopusで検索)
PMID 任意 11964044    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-0036182725
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Pathology, University of Tokushima School of Medicine, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article