72261: Imanishi, Yasuo/Hosokawa, Yoshitaka/[吉本勝彦]/Schipani, Ernestina/Mallya, Sanjay/Papanikolaou, Alexandros/Kifor, Olga/Tokura, Takehiko/Sablosky, Marilyn/Ledgard, Felicia/Grnowicz, Gloria/Wang, C Timothy/Schmidt, V Emmet/Hall, Charles/Brown, M Edward/Bronson, Roderick/Arnold, Andrew/Primary Hyperparathyroidism Caused by Parathyroid-Targeted Overexpression of Cyclin D1 in Transgenic Mice./[The Journal of Clinical Investigation]

著作: Imanishi, Yasuo/Hosokawa, Yoshitaka/[吉本勝彦]/Schipani, Ernestina/Mallya, Sanjay/Papanikolaou, Alexandros/Kifor, Olga/Tokura, Takehiko/Sablosky, Marilyn/Ledgard, Felicia/Grnowicz, Gloria/Wang, C Timothy/Schmidt, V Emmet/Hall, Charles/Brown, M Edward/Bronson, Roderick/Arnold, Andrew/Primary Hyperparathyroidism Caused by Parathyroid-Targeted Overexpression of Cyclin D1 in Transgenic Mice./[The Journal of Clinical Investigation]

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EOID: 878067
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

推奨

Peer Review

カテゴリ

推奨

共著種別

推奨

学究種別

推奨

組織

推奨

徳島大学.医学部

著者

必須

(英) Imanishi, Yasuo

役割任意

貢献度任意

学籍番号推奨
(英) Hosokawa, Yoshitaka

役割任意

貢献度任意

学籍番号推奨
吉本勝彦

役割任意

貢献度任意

学籍番号推奨
(英) Schipani, Ernestina

役割任意

貢献度任意

学籍番号推奨
(英) Mallya, Sanjay

役割任意

貢献度任意

学籍番号推奨
(英) Papanikolaou, Alexandros

役割任意

貢献度任意

学籍番号推奨
(英) Kifor, Olga

役割任意

貢献度任意

学籍番号推奨
(英) Tokura, Takehiko

役割任意

貢献度任意

学籍番号推奨
(英) Sablosky, Marilyn

役割任意

貢献度任意

学籍番号推奨
(英) Ledgard, Felicia

役割任意

貢献度任意

学籍番号推奨
(英) Grnowicz, Gloria

役割任意

貢献度任意

学籍番号推奨
(英) Wang, C Timothy

役割任意

貢献度任意

学籍番号推奨
(英) Schmidt, V Emmet

役割任意

貢献度任意

学籍番号推奨
(英) Hall, Charles

役割任意

貢献度任意

学籍番号推奨
(英) Brown, M Edward

役割任意

貢献度任意

学籍番号推奨
(英) Bronson, Roderick

役割任意

貢献度任意

学籍番号推奨
(英) Arnold, Andrew

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Primary Hyperparathyroidism Caused by Parathyroid-Targeted Overexpression of Cyclin D1 in Transgenic Mice.

副題

任意

要約

任意

(英) The relationship between abnormal cell proliferation and aberrant control of hormonal secretion is a fundamental and poorly understood issue in endocrine cell neoplasia. Transgenic mice with parathyroid-targeted overexpression of the cyclin D1 oncogene, modeling a gene rearrangement found in human tumors, were created to determine whether a primary defect in this cell-cycle regulator can cause an abnormal relationship between serum calcium and parathyroid hormone response, as is typical of human primary hyperparathyroidism. We also sought to develop an animal model of hyperparathyroidism and to examine directly cyclin D1's role in parathyroid tumorigenesis. Parathyroid hormone gene regulatory region--cyclin D1 (PTH--cyclin D1) mice not only developed abnormal parathyroid cell proliferation, but also developed chronic biochemical hyperparathyroidism with characteristic abnormalities in bone and, notably, a shift in the relationship between serum calcium and PTH. Thus, this animal model of human primary hyperparathyroidism provides direct experimental evidence that overexpression of the cyclin D1 oncogene can drive excessive parathyroid cell proliferation and that this proliferative defect need not occur solely as a downstream consequence of a defect in parathyroid hormone secretory control by serum calcium, as had been hypothesized. Instead, primary deregulation of cell-growth pathways can cause both the hypercellularity and abnormal control of hormonal secretion that are almost inevitably linked together in this common disorder.

キーワード

推奨

(英) Adenoma
(英) Animals
(英) Bone and Bones
(英) Calcium
(英) Calcium-Binding Proteins
(英) Chromosome Aberrations
(英) Chromosome Disorders
(英) Cyclin D1
(英) Gene Rearrangement
(英) Humans
(英) Hyperparathyroidism
(英) Mice
(英) Mice, Transgenic
(英) Parathyroid Hormone
(英) Parathyroid Neoplasms

発行所

推奨

誌名

必須

The Journal of Clinical Investigation(The American Society for Clinical Investigation (ASCI))

(pISSN: 0021-9738, eISSN: 1558-8238)

ISSN	任意	0021-9738 ISSN: 0021-9738 (pISSN: 0021-9738, eISSN: 1558-8238) Title: The Journal of clinical investigation Title(ISO): J Clin Invest Publisher: American Society for Clinical Investigation (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

必須

107

号

必須

頁

必須

1093 1102

都市

任意

年月日

必須

2001年 1月初日

URL

任意

DOI

任意

10.1172/JCI10523 (→Scopusで検索)

PMID

任意

11342573 (→Scopusで検索)

CRID

任意

WOS

任意

000168564400009

Scopus

任意

2-s2.0-0035014450

機関リポジトリ

109648

評価値

任意

被引用数

任意

指導教員

推奨

備考

任意

(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't
(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.
(英) OtherID: PMC209274

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