著作: [吉本 勝彦]/[小杉 知里]/Moritani, Miki/Shimizu, Eiji/[山岡 孝]/Yamada, Shozo/[佐野 壽昭]/[板倉 光夫]/Infrequent Detectable Somatic Mutations of the RET and Glial Cell Line-Derived Neurotrophic Factor (GDNF) Genes in Human Pituitary Adenomas./[Endocrine Journal]
ヘルプを読む
「著作」（著作（著書，論文，レター，国際会議など））は，研究業績にかかる著作（著書，論文，レター，国際会議など）を登録するテーブルです． (この情報が属するテーブルの詳細な定義を見る)
- 項目名の部分にマウスカーソルを置いて少し待つと，項目の簡単な説明がツールチップ表示されます．
編集する
複製して登録
削除する| 種別 | 必須 | 学術論文(審査論文) | |||
|---|---|---|---|---|---|
| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | Peer Review | |||
| カテゴリ | 推奨 | ||||
| 共著種別 | 推奨 | ||||
| 学究種別 | 推奨 | ||||
| 組織 | 推奨 | ||||
| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) Infrequent Detectable Somatic Mutations of the RET and Glial Cell Line-Derived Neurotrophic Factor (GDNF) Genes in Human Pituitary Adenomas. |
|||
| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) RET is a receptor tyrosine kinase expressed in neuroendocrine cells and tumors. RET is activated by a ligand complex comprising glial cell line-derived neurotrophic factor (GDNF) and GDNF receptor-alpha (GDNFR-alpha). Activating mutations of the RET proto-oncogene were found in multiple endocrine neoplasia (MEN) 2 and in sporadic medullary thyroid carcinoma and pheochromocytoma of neuroendocrine origin. Mutations of the RET proto-oncogene and the glial cell line-derived neurotrophic factor (GDNF) gene were examined in human pituitary tumors. No mutations of the RET proto-oncogene including the cysteine-rich region or codon 768 and 918 in the tyrosine kinase domain were detected in 172 human pituitary adenomas either by polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP) or by PCR-restriction fragment length polymorphism (RFLP). Further, somatic mutations of the GDNF gene in 33 human pituitary adenomas were not detected by PCR-SSCP. One polymorphism of the GDNF gene at codon 145 of TGC or TGT was observed in a prolactinoma. The RET proto-oncogene message was detected in a normal human pituitary gland or 4 of 4 human pituitary adenomas with reverse transcription (RT)-PCR, and in rodent pituitary tumor cell lines with Western blotting. The expression of GDNF gene was detected in 1 of 4 human somatotroph adenomas, 1 of 2 corticotroph adenomas, and 2 of 6 rodent pituitary tumor cell lines with RT-PCR. Based on these, it is concluded that somatic mutations of the RET proto-oncogene or the GDNF gene do not appear to play a major role in the pituitary tumorigenesis in examined tumors. |
|||
| キーワード | 推奨 |
|
|||
| 発行所 | 推奨 | ||||
| 誌名 | 必須 |
Endocrine Journal([社団法人 日本内分泌学会])
(pISSN: 0918-8959, eISSN: 1348-4540)
|
|||
| 巻 | 必須 | 46 | |||
| 号 | 必須 | 1 | |||
| 頁 | 必須 | 199 207 | |||
| 都市 | 任意 | ||||
| 年月日 | 必須 | 1999年 1月 初日 | |||
| URL | 任意 | ||||
| DOI | 任意 | 10.1507/endocrj.46.199 (→Scopusで検索) | |||
| PMID | 任意 | 10426588 (→Scopusで検索) | |||
| CRID | 任意 | ||||
| WOS | 任意 | ||||
| Scopus | 任意 | ||||
| 機関リポジトリ | 111694 | ||||
| 評価値 | 任意 | ||||
| 被引用数 | 任意 | ||||
| 指導教員 | 推奨 | ||||
| 備考 | 任意 |
|
|||