71704: Oshikawa Tetsuya/[岡本正人]/Ohe Go/Furuichi Sachiko/Nishikawa Hidetomo/Uddin Ahmed Sharif/[吉田秀夫]/Moriya Yoichiro/Matsubara Shuzo/Ryoma Yoshiki/Saito Motoo/[佐藤光信]/Anti-tumor immune response induced by the fractions derived from OK-432, a streptococcal preparation, by using a monoclonal antibody TS-2 that neutralizes the interferon-gamma-inducing activity of OK-432: comparison between the TS-2-binding and TS-2-unbinding fraction./[International Immunopharmacology]

著作: Oshikawa Tetsuya/[岡本正人]/Ohe Go/Furuichi Sachiko/Nishikawa Hidetomo/Uddin Ahmed Sharif/[吉田秀夫]/Moriya Yoichiro/Matsubara Shuzo/Ryoma Yoshiki/Saito Motoo/[佐藤光信]/Anti-tumor immune response induced by the fractions derived from OK-432, a streptococcal preparation, by using a monoclonal antibody TS-2 that neutralizes the interferon-gamma-inducing activity of OK-432: comparison between the TS-2-binding and TS-2-unbinding fraction./[International Immunopharmacology]

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EID: 71704
EOID: 1092374
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LastModified: 2023年10月16日(月) 11:32:39
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Owner: [副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

推奨

カテゴリ

推奨

共著種別

推奨

学究種別

推奨

組織

推奨

徳島大学.歯学部.歯学科

著者

必須

(英) Oshikawa Tetsuya

役割任意

貢献度任意

学籍番号推奨
岡本正人

役割任意

貢献度任意

学籍番号推奨
(英) Ohe Go

役割任意

貢献度任意

学籍番号推奨
(英) Furuichi Sachiko

役割任意

貢献度任意

学籍番号推奨
(英) Nishikawa Hidetomo

役割任意

貢献度任意

学籍番号推奨
(英) Uddin Ahmed Sharif

役割任意

貢献度任意

学籍番号推奨
吉田秀夫

役割任意

貢献度任意

学籍番号推奨
(英) Moriya Yoichiro

役割任意

貢献度任意

学籍番号推奨
(英) Matsubara Shuzo

役割任意

貢献度任意

学籍番号推奨
(英) Ryoma Yoshiki

役割任意

貢献度任意

学籍番号推奨
(英) Saito Motoo

役割任意

貢献度任意

学籍番号推奨
佐藤光信

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Anti-tumor immune response induced by the fractions derived from OK-432, a streptococcal preparation, by using a monoclonal antibody TS-2 that neutralizes the interferon-gamma-inducing activity of OK-432: comparison between the TS-2-binding and TS-2-unbinding fraction.

副題

任意

要約

任意

(英) We have previously isolated a lipoteichoic acid (LTA)-related molecule (OK-PSA) from OK-432, a streptococcal agent, by affinity chromatography on a CNBr-activated Sepharose 4B bound TS-2 monoclonal antibody (mAb) that neutralizes the interferon (IFN)-gamma-inducing activity of OK-432. In the current study, we compared the cytokine-inducing and anti-tumor activities of OK-PSA, a TS-2-binding fraction, with those of OK-PTF, a TS-2-unbinding fraction, in order to determine the efficacy of OK-PSA for clinical use in affinity chromatography using TS-2. In the in vitro experiments using human peripheral blood mononuclear cells (PBMCs), OK-PSA markedly induced Th1-type cytokines, while interleukin (IL)-6 and IL-10, Th2-type cytokines, were induced by OK-PTF. Th1-cytokine induction by OK-PTF was not dose-dependent and was suppressed when PBMCs were treated with a high concentration of OK-PTF. In a mouse model, Th1 cytokines were also induced by OK-PSA and Th2 cytokines were induced by OK-PTF. Th2 cytokine-inducing activity of OK-PTF was accelerated in tumor-bearing mice relative to that in healthy mice. Although the anti-tumor effect of OK-PTF was statistically significant, it was much weaker than that of OK-PSA. A significant difference between the anti-tumor effect of OK-PSA and that of OK-PTF was observed (P<0.05). Finally, OK-PSA elicited its cytokine-inducing effect via Toll-like receptor (TLR) 4, whereas OK-PTF-induced signaling was mediated by both TLR2 and TLR4. These findings strongly suggested that the affinity chromatography using TS-2 is a useful strategy to separate the effective component for cancer therapy (OK-PSA) from other components.

キーワード

推奨

(英) Animals
(英) Antibodies, Monoclonal
(英) Antibodies, Neoplasm
(英) Cells, Cultured
(英) Chromatography, Affinity
(英) Culture Media
細胞質分裂(cytokinesis)
女性(female)
(英) Humans
(英) Hybridomas
(英) In Vitro Techniques
(英) Interferon Inducers
(英) Interferon-gamma
(英) Luciferases
男性(male)
(英) Membrane Glycoproteins
(英) Mice
(英) Mice, Inbred BALB C
(英) Mice, Inbred C57BL
ノックアウトマウス(knockout mice)
(英) Monocytes
(英) Neoplasms
(英) Picibanil
(英) Receptors, Cell Surface
シグナル伝達(signal transduction)
(英) Th1 Cells
(英) Th2 Cells
(英) Toll-Like Receptor 2
(英) Toll-Like Receptor 4
(英) Toll-Like Receptors

発行所

推奨

誌名

必須

International Immunopharmacology([Elsevier])

(pISSN: 1567-5769, eISSN: 1878-1705)

ISSN	任意	1567-5769 ISSN: 1567-5769 (pISSN: 1567-5769, eISSN: 1878-1705) Title: International immunopharmacology Title(ISO): Int Immunopharmacol Publisher: Elsevier B.V. (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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643 655

都市

任意

年月日

必須

2003年 1月初日

URL

任意

DOI

任意

10.1016/S1567-5769(02)00274-6 (→Scopusで検索)

PMID

任意

12757734 (→Scopusで検索)

CRID

任意

WOS

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Scopus

任意

2-s2.0-12444250093

評価値

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被引用数

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指導教員

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備考

任意

(英) Article.PublicationTypeList.PublicationType: Comparative Study
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

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