著作: [吉本 勝彦]/Iwahana, Hiroyuki/[板倉 光夫]/Relatively Good Prognosis of Multiple Endocrine Neoplasia Type 2B in Japanese: Review of Cases in Japan and Analysis of Genetic Changes in Tumors./[Endocrine Journal]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | Peer Review | |||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Relatively Good Prognosis of Multiple Endocrine Neoplasia Type 2B in Japanese: Review of Cases in Japan and Analysis of Genetic Changes in Tumors. |
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副題 | 任意 | ||||
要約 | 任意 |
(英) Since 1968, a total of 23 patients with multiple endocrine neoplasia type 2B (MEN 2B) have been identified in Japan. The mean age at diagnosis was 20.3 years (range, 6 to 39 years). All patients had neuromas and bumpy lips. All patients underwent thyroidectomy for medullary thyroid carcinoma (MTC). Ten of 23 patients had pheochromocytomas. One patient died of cerebral bleeding at the age of 43, 2 patients died of MTC at the age of 35 and 12. Five-, 10-, and 15-year survival rates were 100%, 92%, and 88%, respectively. The clinical course of MTC in MEN 2B in Japanese is not so aggressive when compared with about a 50% 10-year survival reported for Caucasians. Genetic analysis of 4 MTC and 1 pheochromocytoma from 4 patients with MEN 2B revealed no common changes in regard to loss of heterozygosity on 21 chromosomes or point mutations of the ras, Gs alpha, or p53 genes. |
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キーワード | 推奨 |
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発行所 | 推奨 | ||||
誌名 | 必須 |
Endocrine Journal([社団法人 日本内分泌学会])
(pISSN: 0918-8959, eISSN: 1348-4540)
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巻 | 必須 | 40 | |||
号 | 必須 | 6 | |||
頁 | 必須 | 649 657 | |||
都市 | 任意 | ||||
年月日 | 必須 | 1993年 1月 初日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.1507/endocrj.40.649 (→Scopusで検索) | |||
PMID | 任意 | 7951533 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | ||||
機関リポジトリ | 111689 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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