徳島大学 教育・研究者情報データベース(EDB)

1. 鹿草 宏([徳島大学.病院.中央診療施設等.地域脳神経外科診療部])

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. (英) Izumi Yamaguchi

   役割	任意
   貢献度	任意
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3. (英) Kenji Shono / (日) 庄野 健児 / (読) しょうの けんじ

   役割	任意
   貢献度	任意
   学籍番号	推奨	****

4. (英) Yoshifumi Mizobuchi / (日) 溝渕 佳史 / (読) みぞぶち よしふみ

   役割	任意
   貢献度	任意
   学籍番号	推奨	****

5. (英) Eiji Shikata / (日) 四方 英二 / (読) しかた えいじ

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   貢献度	任意
   学籍番号	推奨	****

6. 松田 拓([徳島大学.大学院医歯薬学研究部.医学域.特定研究部門.教育支援系.医学教育支援])

   役割	任意
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7. 宮本 健志([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])

   役割	任意
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8. 原 慶次郎([徳島大学.病院.中央診療施設等.地域脳神経外科診療部])

   役割	任意
   貢献度	任意
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9. (英) Keiko T Kitazato

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10. 宇都 義浩([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命コース])

    役割	任意
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11. (英) Yasuhisa Kanematsu / (日) 兼松 康久 / (読) かねまつ やすひさ

    役割	任意
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    学籍番号	推奨	****

12. 髙木 康志([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])

    役割	任意
    貢献度	任意
    学籍番号	推奨

(英) Differences in amyloid-β and tau/p-tau deposition in blood-injected mouse brains using micro-syringe to mimic traumatic brain microhemorrhages

(英) Cerebral microbleeds (CMBs) due to traumatic brain injuries (TBI) have been shown to lead to cognitive decline and impairment. CMBs caused by TBI may be associated with pathophysiological mechanisms involving inflammation and the accumulation of amyloid-β (Aβ), tau, and phosphorylated tau (p-tau), contributing to cognitive abnormalities. However, their relationships remain unclear. To test our hypothesis that Aβ, tau, and p-tau are accumulated and regulated separately in mice with injuries imitating CMBs from TBI, we studied. Seven-week-old C57BL/6 male mice were injected with 15 μL of heparinized autologous blood or saline by micro-syringe into the front lobe. Expression profiles and regulation of Aβ, tau, and p-tau were assessed immunohistochemically over time. On day 7 after blood injection, Iba-1 and S100B cells in damaged cortex adjacent to the injection site were higher than saline injection group and non-injected sham. On days 3-14, Aβ deposition were gradually increased but normalized by day 28. In contrast, tau/p-tau deposition gradually increased during days 14-28 and dispersed along the corticomedullary junction adjacent to hem deposits, indicating different expression profiles from Aβ. Deposits of Aβ, but not tau/p-tau, were phagocytosed by CD163 macrophages increased by Gc-protein macrophage-activating factor during days 7-28, suggesting different mechanisms of deposition and regulation between Aβ and tau/p-tau. Deposition and regulation differ between Aβ and tau/p-tau in mice with injuries mimicking CMBs from TBI. Further clarification of relationships between the pathologies of cognitive impairment and their neurodegenerative consequences is needed.

1. (英) Amyloid-β
2. (英) Cognitive impairment
3. (英) Tauopathy
4. (英) Traumatic cerebral microbleed

1. (英) Article.ELocationID: 10.1016/j.jchemneu.2023.102258

2. (英) Article.ELocationID: S0891-0618(23)00028-5

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

5. (英) KeywordList.Keyword: Amyloid-β

6. (英) KeywordList.Keyword: Cognitive impairment

7. (英) KeywordList.Keyword: Tauopathy

8. (英) KeywordList.Keyword: Traumatic cerebral microbleed