徳島大学 教育・研究者情報データベース(EDB)

1. (英) Yamakage Hajime

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2. (英) Jo Takaaki

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3. (英) Tanaka Masashi

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4. (英) Kato Sayaka

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5. (英) Hasegawa Koji

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6. (英) Masuda Izuru

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7. 松久 宗英([徳島大学.先端酵素学研究所.基幹研究部門]/徳島大学病院アンチエイジングセンター センター長(併任)/徳島大学先端酵素学研究所長(併任))

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8. (英) Kotani Kazuhiko

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9. (英) Noda Mitsuhiko

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10. (英) Satoh-Asahara Noriko

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(英) Five percent weight loss is a significant 1-year predictor and an optimal 5-year cut-off for reducing the number of obesity-related cardiovascular disease risk components: the Japan Obesity and Metabolic Syndrome Study.

(英) This study aimed to identify the amount of weight loss needed in patients with obesity to improve metabolic syndrome (MetS), a risk factor for cardiovascular disease (CVD), over a long period of time. A total of 576 patients with obesity were enrolled in this study. Effects of continuous physician-supervised weight loss on the cumulative MetS components excluding abdominal circumference (defined as obesity-related CVD risk score) were investigated during a 5-year follow-up period. The extent of weight loss required to reduce the obesity-related CVD risk components was assessed using receiver operating characteristic (ROC) curve analyses. Of the 576 participants, 266 completed 5-year follow-up, with 39.1% and 24.1% of them achieving 5.0% and 7.5% weight loss at the 5-year follow-up, respectively. The area under the ROC curve for reducing the obesity-related CVD risk components was 0.719 [0.662-0.777] at 1 year and 0.694 [0.613-0.775] at 5 years. The optimal cut-off value for weight loss was 5.0% (0.66 sensitivity and 0.69 specificity) and the value with 0.80 specificity was 7.5% (0.45 sensitivity) at 5 years. Greater reductions in weight were associated with greater improvements in the obesity-related CVD risk score at all follow-up periods (-trend <0.001). Obesity-related CVD risk score was significantly improved by 5.0-7.5% and 7.5% weight loss at 1 year ( = 0.029 and < 0.001, respectively) and 7.5% weight loss at 5 years ( = 0.034). A weight loss of 5.0% at 1 year and 7.5% at 5 years could reduce the number of obesity-related CVD risk components in patients with obesity.

1. (英) Humans
2. (英) Metabolic Syndrome
3. (英) Cardiovascular Diseases
4. (英) Japan
5. (英) Obesity
6. (英) Risk Factors

1. (英) PublicationType: Journal Article