徳島大学 教育・研究者情報データベース(EDB)

1. 吉川 幸造

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2. 島田 光生([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])

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3. 森根 裕二([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])

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4. 池本 哲也([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])

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5. 齋藤 裕([徳島大学.病院.診療科.外科.消化器・移植外科])

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6. 山田 眞一郎([徳島大学.病院.診療科.外科.消化器・移植外科])

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7. 寺奥 大貴([徳島大学.病院.中央診療施設等.安全管理部])

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8. 髙尾 正一郎([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.医用画像解析学]/[徳島大学.医学部.保健学科.放射線技術科学専攻.診療放射線技術学講座])

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(英) Clinical impact of myosteatosis measured by magnetic resonance imaging on long-term outcomes of hepatocellular carcinoma after radical hepatectomy.

(英) A variety of factors have been reported to affect long-term outcomes after radical resection of hepatocellular carcinoma (HCC). However, the indicators remain controversial. The purpose of this study was to evaluate the relationship between myosteatosis of the multifidus muscle and long-term outcomes after radical surgery for HCC. We retrospectively analyzed clinicopathological data for 187 patients with HCC who underwent radical surgery at Tokushima University between January 2009 and December 2020 and measured the density of fat in the multifidus muscle at L3 on their preoperative magnetic resonance images (MRI). Associations of myosteatosis and clinicopathological factors with long-term outcomes were evaluated. The patients were divided into a myosteatosis-negative group (n = 122) and a myosteatosis-positive group (n = 65). The cancer-specific survival rate after hepatectomy was significantly worse in the myosteatosis-positive group than in the myosteatosis-negative group (p = 0.03). Univariate analysis identified multiple tumors, stage III/IV disease, an alfa-fetoprotein level ≥ 10 ng/ml, PIVKA-II ≥ 400 AU/ml, vp(+) status, and myosteatosis to be prognostic factors for cancer-specific survival. Multivariate analysis revealed multiple tumors, an alfa-fetoprotein level ≥ 10 ng/ml, and myosteatosis to be independent prognostic factors. Myosteatosis measured by MRI is a simple and useful predictor of the long-term outcome after radical surgery for HCC.

1. (英) Humans
2. (英) Carcinoma, Hepatocellular
3. (英) Hepatectomy
4. (英) Retrospective Studies
5. (英) Liver Neoplasms
6. (英) Magnetic Resonance Imaging
7. (英) Fetal Proteins

1. (英) Article.ELocationID: 281

2. (英) Article.ELocationID: 10.1186/s12893-023-02188-z

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) KeywordList.Keyword: Hepatocellular carcinoma

5. (英) KeywordList.Keyword: Magnetic resonance imaging

6. (英) KeywordList.Keyword: Myosteatosis

7. (英) KeywordList.Keyword: Radical hepatectomy

8. (英) KeywordList.Keyword: cancer-specific survival

9. (英) CoiStatement: The authors declare no competing interests.