徳島大学 教育・研究者情報データベース(EDB)

1. (英) ALi Hanif / (日) Md Hanif Ali / (読) むはまど はにふ あり

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2. (英) Yamanishi Mone / (日) 山西 百音 / (読) やまにし もね

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3. (英) Sunagawa Keigo / (日) 砂川 佳吾 / (読) すながわ けいご

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4. (英) Kumon Mizuki / (日) 公門 瑞希 / (読) くもん みずき

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5. (英) Hasi Yesmin Rumana / (日) Rumana Yesmin Hasi / (読) るまな いえすみん はし

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6. 粟飯原 睦美([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系])

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7. 川上 竜巳([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野]/[徳島大学.生物資源産業学部])

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8. 田中 保([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野])

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(英) Protective effect of oleic acid against very long-chain fatty acid-induced apoptosis in peroxisome-deficient CHO cells

(英) Very long-chain fatty acids (VLCFAs) are degraded exclusively in peroxisomes, as evidenced by the accumulation of VLCFAs in patients with certain peroxisomal disorders. Although accumulation of VLCFAs is considered to be associated with health issues, including neuronal degeneration, the mechanisms underlying VLCFAs-induced tissue degeneration remain unclear. Here, we report the toxic effect of VLCFA and protective effect of C18: 1 FA in peroxisome-deficient CHO cells. We examined the cytotoxicity of saturated and monounsaturated VLCFAs with chain-length at C20-C26, and found that longer and saturated VLCFA showed potent cytotoxicity at lower accumulation levels. Furthermore, the extent of VLCFA-induced toxicity was found to be associated with a decrease in cellular C18:1 FA levels. Notably, supplementation with C18:1 FA effectively rescued the cells from VLCFA-induced apoptosis without reducing the cellular VLCFAs levels, implying that peroxisome-deficient cells can survive in the presence of accumulated VLCFA, as long as the cells keep sufficient levels of cellular C18:1 FA. These results suggest a therapeutic potential of C18:1 FA in peroxisome disease and may provide new insights into the pharmacological effect of Lorenzo's oil, a 4:1 mixture of C18:1 and C22:1 FA.

1. (英) Article.ELocationID: 10.1016/j.bbalip.2024.159452

2. (英) Article.ELocationID: S1388-1981(24)00002-7

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) KeywordList.Keyword: Apoptosis

5. (英) KeywordList.Keyword: Oleic acid

6. (英) KeywordList.Keyword: Peroxisome disease

7. (英) KeywordList.Keyword: Very long-chain fatty acids

8. (英) CoiStatement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.