徳島大学 教育・研究者情報データベース(EDB)

1. (英) Li Danxi

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2. (英) Hu Di

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3. (英) Ochi Yuta

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4. (英) Arakaki Wakako

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5. (英) Mawatari Aya

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6. (英) Shigeta Mika

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7. (英) Wu Yuping

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8. (英) Hayashinaka Emi

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9. (英) Neyama Hiroyuki

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10. 田原 強([徳島大学.先端研究推進センター.バイオイメージング研究部門])

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11. (英) Wada Yasuhiro

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12. (英) Li Feng

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13. (英) Doi Hisashi

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14. (英) Watanabe Yasuyoshi

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15. (英) Cui Yilong

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(英) Regional neuroinflammation induced by peripheral infection contributes to fatigue-like symptoms: a [¹⁸F]DPA-714 positron emission tomography study in rats

(英) A series of symptoms, including fever, widespread pain, fatigue, and even ageusia, have frequently been reported in the context of various infections, such as COVID-19. Although the pathogenic mechanisms underlying an infection causing fever and pain have been well established, the mechanisms of fatigue induced by infection in specific brain regions remain unclear. To elucidate whether and how the peripheral infection cause fatigue via regional neuroinflammation, we performed a brain-wide investigation of neuroinflammation in a peripheral pseudoinfection rat model using [F]DPA-714 positron emission tomography (PET) imaging analysis, in which the polyriboinosinic: polyribocytidylic acid (poly I:C) was intraperitoneally injected. Transient fever lasting for several hours and subsequent suppression of spontaneous activity lasting a few days were induced by poly I:C treatment. Significant increase in plasma interleukin (IL)-1β, IL-6 and tumour necrosis factor (TNF)-α were observed at 2 and 4 h following poly I:C treatment. PET imaging analysis revealed that the brain uptake of [F]DPA-714 was significantly increased in several brain regions one day after poly I:C treatment, such as the dorsal raphe (DR), parvicellular part of red nucleus (RPC), A5 and A7 noradrenergic nucleus, compared with the control group. The accumulation of [F]DPA-714 in the DR, RPC and A5 was positively correlated with subsequent fatigue-like behavior, and that in the A7 tended to positively correlate with fever. These findings suggest that peripheral infection may trigger regional neuroinflammation, which may cause specific symptoms such as fatigue. A similar mechanism might be involved in COVID-19.

1. (英) Rats
2. (英) Animals
3. (英) Neuroinflammatory Diseases
4. (英) Positron-Emission Tomography
5. (英) Pain
6. (英) COVID-19
7. (英) Poly I

1. (英) Article.ELocationID: 1261256

2. (英) Article.ELocationID: 10.3389/fimmu.2023.1261256

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) KeywordList.Keyword: PET

5. (英) KeywordList.Keyword: fatigue-like symptoms

6. (英) KeywordList.Keyword: peripheral infection

7. (英) KeywordList.Keyword: regional neuroinflammation

8. (英) KeywordList.Keyword: sickness behavior

9. (英) CoiStatement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.