徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: 植村 勇太/[木下 倫子]/[酒井 陽子]/[田中 克哉]/Hemodynamic impact of ephedrine on hypotension during general anesthesia: a prospective cohort study on middle-aged and older patients/[BMC Anesthesiology]/[木下 倫子]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
402446
EOID
1091043
Map
0
LastModified
2023年9月14日(木) 15:18:39
Operator
新見 優子
Avail
TRUE
Censor
0
Owner
木下 倫子
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨 学内共著(徳島大学内研究者との共同研究 (学外研究者を含まない))
学究種別 推奨 博士課程学生による研究報告
組織 推奨
著者 必須
  1. (英) Uemura Yuta / (日) 植村 勇太 / (読) うえむら ゆうた
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  2. 木下 倫子([徳島大学.病院.診療科.脳·神経·精神科.麻酔科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 酒井 陽子([徳島大学.病院.中央診療施設等.麻酔科診療部])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 田中 克哉([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Hemodynamic impact of ephedrine on hypotension during general anesthesia: a prospective cohort study on middle-aged and older patients

副題 任意
要約 任意

(英) Ephedrine is a mixed α- and β-agonist vasopressor that is frequently used for the correction of hypotension during general anesthesia. β-responsiveness has been shown to decrease with age; therefore, this study aimed to determine whether aging would reduce the pressor effect of ephedrine on hypotension during general anesthesia. Seventy-five patients aged ≥ 45 years were included in this study, with 25 patients allocated to each of the three age groups: 45-64 years, 65-74 years, and ≥ 75 years. All patients received propofol, remifentanil, and rocuronium for the induction of general anesthesia, followed by desflurane and remifentanil. Cardiac output (CO) was estimated using esCCO technology. Ephedrine (0.1 mg/kg) was administered for the correction of hypotension. The primary and secondary outcome measures were changes in the mean arterial pressure (MAP) and CO, respectively, at 5 min after the administration of ephedrine. RESULTS: The administration of ephedrine significantly increased MAP (p < 0.001, mean difference: 8.34 [95% confidence interval (CI), 5.95-10.75] mmHg) and CO (p < 0.001, mean difference: 7.43 [95% CI, 5.20-9.65] %) across all groups. However, analysis of variance revealed that the degree of elevation of MAP (F [2, 72] = 0.546, p = 0.581, η = 0.015 [95% CI, 0.000-0.089]) and CO (F [2, 72] = 2.023, p = 0.140, η = 0.053 [95% CI, 0.000-0.162]) did not differ significantly among the groups. Similarly, Spearman's rank correlation and multiple regression analysis revealed no significant relation between age and the changes in MAP or CO after the administration of ephedrine. The administration of ephedrine significantly increased MAP and CO; however, no significant correlation with age was observed in patients aged > 45 years. These findings suggest that ephedrine is effective for the correction of hypotension during general anesthesia, even in elderly patients. UMIN-CTR (UMIN000045038; 02/08/2021).

キーワード 推奨
  1. (英) Aged
  2. (英) Middle Aged
  3. (英) Humans
  4. (英) Ephedrine
  5. (英) Prospective Studies
  6. (英) Remifentanil
  7. (英) Hemodynamics
  8. (英) Hypotension
  9. (英) Vasoconstrictor Agents
  10. (英) Anesthesia, General
発行所 推奨
誌名 必須 BMC Anesthesiology([BioMed Central Ltd.])
(eISSN: 1471-2253)
ISSN 任意 1471-2253
ISSN: 1471-2253 (eISSN: 1471-2253)
Title: BMC anesthesiology
Title(ISO): BMC Anesthesiol
Publisher: BioMed Central
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 23
必須 1
必須 283 283
都市 任意
年月日 必須 2023年 8月 22日
URL 任意
DOI 任意 10.1186/s12871-023-02244-4    (→Scopusで検索)
PMID 任意 37608253    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意 2-s2.0-85168706206
評価値 任意
被引用数 任意
指導教員 推奨
  1. 木下 倫子([徳島大学.病院.診療科.脳·神経·精神科.麻酔科])
備考 任意
  1. (英) Article.ELocationID: 10.1186/s12871-023-02244-4

  2. (英) Article.DataBankList.DataBank.DataBankName: JPRN

  3. (英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: UMIN000045038

  4. (英) Article.PublicationTypeList.PublicationType: Journal Article

  5. (英) KeywordList.Keyword: Aging

  6. (英) KeywordList.Keyword: Elderly

  7. (英) KeywordList.Keyword: Ephedrine

  8. (英) KeywordList.Keyword: Hemodynamics

  9. (英) KeywordList.Keyword: Hypotension