399621: Gerhard Jung/Eva Hernández-Illán/Juan J Lozano/Julia Sidorova/Jenifer Muñoz/[岡田泰行]/Enrique Quintero/Goretti Hernandez/Rodrigo Jover/Sabela Carballal/Miriam Cuatrecasas/Lorena Moreno/Mireia Diaz/Teresa Ocaña/Ariadna Sánchez/Liseth Rivero/Oswaldo Ortiz/Joan Llach/Antoni Castells/Maria Pellisé/Ajay Goel/Eduard Batlle/Francesc Balaguer/Epigenome-Wide DNA Methylation Profiling of Normal Mucosa Reveals HLA-F Hypermethylation as a Biomarker Candidate for Serrated Polyposis Syndrome/[The Journal of Molecular Diagnostics : JMD]

著作: Gerhard Jung/Eva Hernández-Illán/Juan J Lozano/Julia Sidorova/Jenifer Muñoz/[岡田泰行]/Enrique Quintero/Goretti Hernandez/Rodrigo Jover/Sabela Carballal/Miriam Cuatrecasas/Lorena Moreno/Mireia Diaz/Teresa Ocaña/Ariadna Sánchez/Liseth Rivero/Oswaldo Ortiz/Joan Llach/Antoni Castells/Maria Pellisé/Ajay Goel/Eduard Batlle/Francesc Balaguer/Epigenome-Wide DNA Methylation Profiling of Normal Mucosa Reveals HLA-F Hypermethylation as a Biomarker Candidate for Serrated Polyposis Syndrome/[The Journal of Molecular Diagnostics : JMD]

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EID: 399621
EOID: 1086181
Map: 0
LastModified: 2023年8月22日(火) 19:44:29
Operator: 大家隆弘
Avail: TRUE
Censor: 0
Owner: 岡田泰行
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Delete: 継承

種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

必須

(英) Gerhard Jung

役割任意

貢献度任意

学籍番号推奨
(英) Eva Hernández-Illán

役割任意

貢献度任意

学籍番号推奨
(英) Juan J Lozano

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学籍番号推奨
(英) Julia Sidorova

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貢献度任意

学籍番号推奨
(英) Jenifer Muñoz

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貢献度任意

学籍番号推奨
岡田泰行([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.消化器内科])

役割任意

貢献度任意

学籍番号推奨
(英) Enrique Quintero

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学籍番号推奨
(英) Goretti Hernandez

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学籍番号推奨
(英) Rodrigo Jover

役割任意

貢献度任意

学籍番号推奨
(英) Sabela Carballal

役割任意

貢献度任意

学籍番号推奨
(英) Miriam Cuatrecasas

役割任意

貢献度任意

学籍番号推奨
(英) Lorena Moreno

役割任意

貢献度任意

学籍番号推奨
(英) Mireia Diaz

役割任意

貢献度任意

学籍番号推奨
(英) Teresa Ocaña

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貢献度任意

学籍番号推奨
(英) Ariadna Sánchez

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貢献度任意

学籍番号推奨
(英) Liseth Rivero

役割任意

貢献度任意

学籍番号推奨
(英) Oswaldo Ortiz

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学籍番号推奨
(英) Joan Llach

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貢献度任意

学籍番号推奨
(英) Antoni Castells

役割任意

貢献度任意

学籍番号推奨
(英) Maria Pellisé

役割任意

貢献度任意

学籍番号推奨
(英) Ajay Goel

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貢献度任意

学籍番号推奨
(英) Eduard Batlle

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学籍番号推奨
(英) Francesc Balaguer

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貢献度任意

学籍番号推奨

題名

必須

(英) Epigenome-Wide DNA Methylation Profiling of Normal Mucosa Reveals HLA-F Hypermethylation as a Biomarker Candidate for Serrated Polyposis Syndrome

副題

任意

要約

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(英) Serrated polyposis syndrome (SPS) is associated with a high risk for colorectal cancer. Intense promoter hypermethylation is a frequent molecular finding in the serrated pathway and may be present in normal mucosa, predisposing to the formation of serrated lesions. To identify novel biomarkers for SPS, fresh-frozen samples of normal mucosa from 50 patients with SPS and 19 healthy individuals were analyzed by using the 850K BeadChip Technology (Infinium). Aberrant methylation levels were correlated with gene expression using a next-generation transcriptome profiling tool. Two validation steps were performed on independent cohorts: first, on formalin-fixed, paraffin-embedded tissue of the normal mucosa; and second, on 24 serrated lesions. The most frequently hypermethylated genes were HLA-F, SLFN12, HLA-DMA, and RARRES3; and the most frequently hypomethylated genes were PIWIL1 and ANK3 (Δβ = 10%; P < 0.05). Expression levels of HLA-F, SLFN12, and HLA-DMA were significantly different between SPS patients and healthy individuals and correlated well with the methylation status of the corresponding differentially methylated region (fold change, >20%; r > 0.55; P < 0.001). Significant hypermethylation of CpGs in the gene body of HLA-F was also found in serrated lesions (Δβ = 23%; false discovery rate = 0.01). Epigenome-wide methylation profiling has revealed numerous differentially methylated CpGs in normal mucosa from SPS patients. Significant hypermethylation of HLA-F is a novel biomarker candidate for SPS.

キーワード

推奨

(英) Adenomatous Polyposis Coli
(英) Argonaute Proteins
(英) Biomarkers
(英) Colorectal Neoplasms
(英) DNA Methylation
(英) Epigenome
(英) Histocompatibility Antigens Class I
(英) Humans
(英) Mucous Membrane

発行所

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誌名

必須

The Journal of Molecular Diagnostics : JMD([American Society for Investigative Pathology]/Association for Molecular Pathology)

(pISSN: 1525-1578, eISSN: 1943-7811)

ISSN	任意	1943-7811 ISSN: 1525-1578 (pISSN: 1525-1578, eISSN: 1943-7811) Title: The Journal of molecular diagnostics : JMD Title(ISO): J Mol Diagn Publisher: American Society for Investigative Pathology (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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674 686

都市

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年月日

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2022年 6月初日

URL

任意

DOI

任意

10.1016/j.jmoldx.2022.03.010 (→Scopusで検索)

PMID

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35447336 (→Scopusで検索)

CRID

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WOS

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Scopus

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評価値

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被引用数

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指導教員

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備考

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(英) Article.ELocationID: 10.1016/j.jmoldx.2022.03.010
(英) Article.ELocationID: S1525-1578(22)00102-7
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

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