徳島大学 教育・研究者情報データベース(EDB)

1. 福場 真美([徳島大学.病院.診療科.歯科口腔外科.口腔内科]/[徳島大学.病院.先端歯科医療開発研究プロジェクト])

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2. 新垣 理恵子

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3. 牛尾 綾

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4. 大塚 邦紘([徳島大学.病院.先端歯科医療開発研究プロジェクト]/[徳島大学.病院.診療科.歯科口腔外科.口腔外科])

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5. (英) Nagao Ruka / (日) 永尾 瑠佳 / (読) ながお るか

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6. (英) Matsuzawa Shigefumi / (日) 松澤 鎮史 / (読) まつざわ しげふみ

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7. (英) Tawara Hiroaki / (日) 俵 宏彰 / (読) たわら ひろあき

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8. 常松 貴明([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])

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9. 石丸 直澄

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(英) CD4 T-cell-dependent differentiation of CD23 follicular B cells contributes to the pulmonary pathology in a primary Sjögren's syndrome mouse model.

(英) Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease that affects the function of exocrine glands, such as the lacrimal and the salivary glands. Extraglandular lesions and malignant lymphoma also occur during the progressive stage of pSS. We have, herein, focused on the pulmonary lesions of pSS and have aimed clarifying their pathophysiological mechanism by comparing the glandular with the extraglandular lesions observed in a mouse model of pSS. The histopathological analysis of lung tissues obtained from NFS/ mice that have undergone neonatal thymectomy was performed. Moreover, and experiments were conducted along with immunological analyses in order to characterize the unique phenotypes of the pulmonary lesions identified in these pSS model mice. Inflammatory lesions with a bronchus-associated lymphoid tissue-like structure were identified in the lungs of pSS model mice. In addition, relative to salivary gland lesions, pulmonary lesions showed increased CD23 follicular B (FB) cells. and pulmonary B cells were more readily driven to CD23 FB cell phenotype than salivary gland B cells in pSS model mice. Furthermore, the CD23 FB cell differentiation was found to be enhanced in a CD4 T-cell-dependent manner under a Th2-type condition in the lungs of herein examined pSS model mice. A Th2-type response in the pSS lung may promote the progression of autoimmune lesions through an enhanced abnormal differentiation of B cells.

1. (英) Mice
2. (英) Animals
3. シェーグレン症候群(Sjögren's syndrome)
4. 唾液腺(salivary glands/->キーワード[唾液腺])
5. (英) B-Lymphocytes
6. 細胞分化(cell differentiation)
7. (英) CD4-Positive T-Lymphocytes

1. (英) Article.ELocationID: 1217492

2. (英) Article.ELocationID: 10.3389/fimmu.2023.1217492

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

5. (英) KeywordList.Keyword: CD23

6. (英) KeywordList.Keyword: CD4+ T cell

7. (英) KeywordList.Keyword: bronchus-associated lymphoid tissue

8. (英) KeywordList.Keyword: follicular B cell

9. (英) KeywordList.Keyword: primary Sjögren's syndrome

10. (英) KeywordList.Keyword: pulmonary lesion

11. (英) CoiStatement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.