徳島大学 教育・研究者情報データベース(EDB)

1. 飛梅 亮

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. 三橋 惇志([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. 西條 敦郎

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. 荻野 広和([徳島大学.病院.診療科.内科.呼吸器・膠原病内科])

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. (英) Afroj Tania / (日) Tania Afroj / (読) たにあ あふろず

   役割	任意
   貢献度	任意
   学籍番号	推奨	****

6. 小川 博久([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. 後東 久嗣

   役割	任意
   貢献度	任意
   学籍番号	推奨

8. 佐藤 正大([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学]/[徳島大学.病院.診療科.内科.呼吸器・膠原病内科])

   役割	任意
   貢献度	任意
   学籍番号	推奨

9. 阿部 あかね

   役割	任意
   貢献度	任意
   学籍番号	推奨

10. 土師 恵子([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])

    役割	任意
    貢献度	任意
    学籍番号	推奨	****

11. 尾崎 領彦([徳島大学.病院.診療科.内科.呼吸器・膠原病内科])

    役割	任意
    貢献度	任意
    学籍番号	推奨	****

12. 滝沢 宏光([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学]/[徳島大学.病院.診療科.外科.呼吸器外科])

    役割	任意
    貢献度	任意
    学籍番号	推奨

13. 西岡 安彦([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])

    役割	任意
    貢献度	任意
    学籍番号	推奨

(英) Analysis of the chemotactic factors for tumor-infiltrating fibrocytes and their prognostic significances in lung cancer.

(英) Fibrocytes, which are bone marrow-derived collagen-producing cells, have been reported to be involved in pathogenesis of pulmonary fibrosis. Our previous study reported that tumor-infiltrating fibrocytes play a role in tumor progression and drug resistance in lung cancer. The present study therefore examined chemotactic factors for fibrocytes in tissues of non-small cell lung cancer (NSCLC) and their prognostic significance. Surgically resected tumor tissues were examined for the expression of chemotactic factors, including C-X-C motif chemokine 12 (CXCL12), CCL2, platelet-derived growth factor (PDGF)-AA and PDGF-BB, as well as tumor-infiltrating fibrocytes by immunostaining. The chemotactic ability of fibrocytes in response to each factor was evaluated using a migration assay by counting the migrated cells microscopically, and expression of receptors for chemotactic factors were analyzed by flow cytometry. The expression of CXCL12, but not CCL2, PDGF-AA, or PDGF-BB, was associated with the number of tumor-infiltrating fibrocytes in lung adenocarcinoma (LUAD), but not lung squamous cell carcinoma (LUSQ). In addition, patients with an increased expression of CXCL12 in LUAD but not LUSQ showed a significantly poorer prognosis compared with those with a decreased expression. However, the expression of CCL2, PDGF-AA and PDGF-BB was not correlated with the prognosis of patients with NSCLC. The number of fibrocytes was associated with a poor prognosis in LUAD. Fibrocytes derived from the peripheral blood of healthy subjects as well as patients with lung cancer expressed higher levels of CXCR4 compared with CCR2, PDGF and receptor-α and receptor-β. Overall, these results suggested that targeting tumor-infiltrating fibrocytes via the CXCL12/CXCR4 axis may be a useful strategy for controlling the progression of NSCLC, particularly LUAD.

1. (英) PublicationType: Journal Article