395889: 大前奈央/[山田苑子]/古本太希/和田京子/林遼/北尾緑/山中彩夏/久保みゆ/松岡百百世/[神村盛一郎]/[島田亜紀]/[佐藤紀]/[北村嘉章]/[加藤真介]/[武田憲昭]/[濵田康弘]/Muscle mass, quality, and strength; physical function and activity; and metabolic status in cachectic patients with head and neck cancer./[Clinical Nutrition ESPEN]/[山田苑子]

著作: 大前奈央/[山田苑子]/古本太希/和田京子/林遼/北尾緑/山中彩夏/久保みゆ/松岡百百世/[神村盛一郎]/[島田亜紀]/[佐藤紀]/[北村嘉章]/[加藤真介]/[武田憲昭]/[濵田康弘]/Muscle mass, quality, and strength; physical function and activity; and metabolic status in cachectic patients with head and neck cancer./[Clinical Nutrition ESPEN]/[山田苑子]

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EID: 395889
EOID: 1077375
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LastModified: 2023年6月12日(月) 20:32:53
Operator: 大家隆弘
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Owner: 安井苑子
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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カテゴリ

推奨

共著種別

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学究種別

推奨

組織

推奨

著者

必須

(英) Omae Nao / (日) 大前奈央 / (読) おおまえなお

役割任意

貢献度任意

学籍番号推奨 ****
山田苑子([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学]/[徳島大学.医学部.医科栄養学科.臨床実践栄養学講座.代謝栄養学]/->個人[安井苑子])

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学籍番号推奨
(英) Furumoto Taiki / (日) 古本太希 / (読) ふるもとたいき

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学籍番号推奨 ****
(英) Wada Kyoko / (日) 和田京子 / (読) わだきょうこ

役割任意

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学籍番号推奨 ****
(英) Hayashi Haruka / (日) 林遼 / (読) はやしはるか

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学籍番号推奨 ****
(英) Kitao Midori / (日) 北尾緑 / (読) きたおみどり

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学籍番号推奨 ****
(英) Ayaka YAMANAKA / (日) 山中彩夏 / (読) やまなかあやか

役割任意

貢献度任意

学籍番号推奨 ****
(英) Kubo Miyu / (日) 久保みゆ / (読) くぼみゆ

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学籍番号推奨 ****
(英) Matsuoka Momoyo / (日) 松岡百百世 / (読) まつおかももよ

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学籍番号推奨 ****
神村盛一郎([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.感覚·皮膚·運動機能科.耳鼻咽喉科・頭頸部外科])

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貢献度任意

学籍番号推奨
島田亜紀

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学籍番号推奨
佐藤紀([徳島大学.病院.中央診療施設等.リハビリテーション部])

役割任意

貢献度任意

学籍番号推奨
北村嘉章([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.耳鼻咽喉科学]/[徳島大学.病院.診療科.感覚·皮膚·運動機能科.耳鼻咽喉科・頭頸部外科])

役割任意

貢献度任意

学籍番号推奨
加藤真介

役割任意

貢献度任意

学籍番号推奨
武田憲昭

役割任意

貢献度任意

学籍番号推奨
濵田康弘([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.疾患治療栄養学])

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貢献度任意

学籍番号推奨

題名

必須

(英) Muscle mass, quality, and strength; physical function and activity; and metabolic status in cachectic patients with head and neck cancer.

副題

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要約

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(英) Cancer cachexia is commonly associated with poor prognosis in patients with head and neck cancer (HNC). However, its pathophysiology and treatment are not well established. The current study aimed to assess the muscle mass/quality/strength, physical function and activity, resting energy expenditure (REE), and respiratory quotient (RQ) in cachectic patients with HNC. This prospective cross-sectional study analyzed 64 patients with HNC. Body composition was measured via direct segmental multifrequency bioelectrical impedance analysis, and muscle quality was assessed using echo intensity on ultrasonography images. Muscle strength was investigated utilizing handgrip strength and isometric knee extension force (IKEF). Physical function was evaluated using the 10-m walking speed test and the five times sit-to-stand (5-STS) test. Physical activity was examined using a wearable triaxial accelerometer. REE and RQ were measured via indirect calorimetry. These parameters were compared between the cachectic and noncachectic groups. In total, 23 (36%) patients were diagnosed with cachexia. The cachectic group had a significantly lower muscle mass than the noncachectic group. Nevertheless, there was no significant difference in terms of fat between the two groups. The cachectic group had a higher quadriceps echo intensity and a lower handgrip strength and IKEF than the noncachectic group. Moreover, they had a significantly slower normal and maximum walking speed and 5-STS speed. The number of steps, total activity time, and time of activity (<3 Mets) did not significantly differ between the two groups. The cachectic group had a shorter time of activity (≥3 Mets) than the noncachectic group. Furthermore, the cachectic group had a significantly higher REE/body weight and REE/fat free mass and a significantly lower RQ than the noncachectic group. The cachectic group had a lower muscle mass/quality/strength and physical function and activity and a higher REE than the noncachectic group. Thus, REE and physical activity should be evaluated to determine energy requirements. The RQ was lower in the cachectic group than that in the noncachectic group, indicating changes in energy substrate. Further studies must be conducted to examine effective nutritional and exercise interventions for patients with cancer cachexia.

キーワード

推奨

(英) Humans
(英) Cachexia
(英) Hand Strength
(英) Cross-Sectional Studies
(英) Prospective Studies
(英) Head and Neck Neoplasms
(英) Quadriceps Muscle

発行所

推奨

誌名

必須

Clinical Nutrition ESPEN(European Society for Clinical Nutrition and Metabolism)

(eISSN: 2405-4577)

ISSN	任意	2405-4577 ISSN: 2405-4577 (eISSN: 2405-4577) Title: Clinical nutrition ESPEN Title(ISO): Clin Nutr ESPEN Publisher: Elsevier Ltd (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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---

頁

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113 119

都市

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年月日

必須

2023年 2月初日

URL

任意

DOI

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10.1016/j.clnesp.2022.12.006 (→Scopusで検索)

PMID

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36657901 (→Scopusで検索)

CRID

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WOS

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Scopus

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評価値

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被引用数

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指導教員

推奨

山田苑子([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学]/[徳島大学.医学部.医科栄養学科.臨床実践栄養学講座.代謝栄養学]/->個人[安井苑子])

備考

任意

(英) Article.ELocationID: 10.1016/j.clnesp.2022.12.006
(英) Article.ELocationID: S2405-4577(22)01416-4
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't
(英) KeywordList.Keyword: Cachexia
(英) KeywordList.Keyword: Head and neck cancer
(英) KeywordList.Keyword: Muscle function
(英) KeywordList.Keyword: Physical activity
(英) KeywordList.Keyword: Respiratory quotient
(英) KeywordList.Keyword: Resting energy expenditure
(英) CoiStatement: Declarations of competing interest The authors declare no conflict of interest.

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