著作: Husseini A. Rabab/[福田 達也]/[大園 瑞音]/Hasan A. Azza/Megrab, El A. Nagia/[小暮 健太朗]/The effect of iontophoretic-delivered polyplex vaccine on melanoma regression/[Biological & Pharmaceutical Bulletin]/[小暮 健太朗]
ヘルプを読む
「著作」（著作（著書，論文，レター，国際会議など））は，研究業績にかかる著作（著書，論文，レター，国際会議など）を登録するテーブルです． (この情報が属するテーブルの詳細な定義を見る)
- 項目名の部分にマウスカーソルを置いて少し待つと，項目の簡単な説明がツールチップ表示されます．
編集する
複製して登録
削除する| 種別 | 必須 | 学術論文(審査論文) | |||
|---|---|---|---|---|---|
| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | Peer Review | |||
| カテゴリ | 推奨 | 研究 | |||
| 共著種別 | 推奨 | ||||
| 学究種別 | 推奨 | ||||
| 組織 | 推奨 | ||||
| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) The effect of iontophoretic-delivered polyplex vaccine on melanoma regression |
|||
| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) Although the strategy in cancer vaccination is to provide a therapeutic effect against an established tumor, there is an urgent need to develop prophylactic vaccines for non-viral cancers. In this study, we prepared polyplex nanoparticles through electrostatic interactions between a positively-charged modified tumor associated antigen, namely human derived melanoma gp100 peptide (KVPRNQDWL-RRRR), and a negatively charged cytosine-phosphate-guanosine motif (CpG-ODN) adjuvant. We previously demonstrated successful transdermal delivery of various hydrophilic macromolecules by iontophoresis (IP) using weak electricity. Herein, we investigated the effectiveness of IP in the transdermal delivery of a prophylactic polyplex vaccine. IP was successful in establishing a homogenous distribution of the vaccine throughout skin. Efficacy of the vaccine was demonstrated against melanoma growth. A significant tumor regression effect was observed, which was confirmed by elevated mRNA expression levels of various cytokines, mainly interferon (IFN)-γ, as well as infiltration of cytotoxic CD8 T cells. Additionally, we evaluated the therapeutic effect of the vaccine and we found a significant reduction in tumor burden. Stimulation of systemic immunity was confirmed by upregulation of IFN-γ. This is the first report to demonstrate the use of IP in the transdermal delivery of a prophylactic melanoma vaccine. |
|||
| キーワード | 推奨 |
|
|||
| 発行所 | 推奨 | ||||
| 誌名 | 必須 |
Biological & Pharmaceutical Bulletin([日本薬学会])
(pISSN: 0918-6158, eISSN: 1347-5215)
|
|||
| 巻 | 必須 | 46 | |||
| 号 | 必須 | 3 | |||
| 頁 | 必須 | 494 504 | |||
| 都市 | 任意 | ||||
| 年月日 | 必須 | 2023年 3月 初日 | |||
| URL | 任意 | ||||
| DOI | 任意 | 10.1248/bpb.b22-00873 (→Scopusで検索) | |||
| PMID | 任意 | 36858579 (→Scopusで検索) | |||
| CRID | 任意 | ||||
| WOS | 任意 | ||||
| Scopus | 任意 | ||||
| 評価値 | 任意 | ||||
| 被引用数 | 任意 | ||||
| 指導教員 | 推奨 |
|
|||
| 備考 | 任意 |
|
|||