徳島大学 教育・研究者情報データベース(EDB)

1. (英) Matsuda Noritake / (日) 松田 憲武 / (読) まつだ のりたけ

   役割	任意
   貢献度	任意
   学籍番号	推奨	****

2. 大塚 秀樹([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.画像医学・核医学]/[徳島大学.医学部.保健学科.放射線技術科学専攻.診療放射線技術学講座])

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. 大谷 環樹([徳島大学.放射線総合センター])

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. (英) Azane Shota

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. (英) Kunikane Yamato

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. (英) Otomi Yoichi

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. (英) Ueki Yuya / (日) 植木 勇弥 / (読) うえき ゆうや

   役割	任意
   貢献度	任意
   学籍番号	推奨	****

8. (英) Kubota Masahiro

   役割	任意
   貢献度	任意
   学籍番号	推奨

9. (英) Amano Masafumi

   役割	任意
   貢献度	任意
   学籍番号	推奨

10. 八木 秀介([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.地域・家庭医療学])

    役割	任意
    貢献度	任意
    学籍番号	推奨

11. 佐田 政隆([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])

    役割	任意
    貢献度	任意
    学籍番号	推奨

12. 原田 雅史([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学])

    役割	任意
    貢献度	任意
    学籍番号	推奨

(英) New quantitative indices of cardiac amyloidosis with 99mTc-pyrophosphate scintigraphy

(英) Amyloid light chain (AL) and transthyretin (ATTR) are the major subtypes of cardiac amyloidosis (CA). Tc-pyrophosphate (PYP) scintigraphy is used to differentiate ATTR from other CA subtypes. We adapted the standardized uptake value (SUV) for Tc-PYP and proposed two quantitative indices, amyloid deposition volume (AmyDV) and total amyloid uptake (TAU). This study aimed to evaluate the utility of these quantitative indices in differentiating ATTR from non-ATTRs. Before the SUV measurement, the Becquerel calibration factor (BCF) of Tc was obtained by a phantom experiment. Thirty-two patients who had undergone hybrid SPECT/CT imaging 3 h after injection of Tc-PYP (370 MBq) were studied. CT attenuation correction for image reconstruction was applied in all. We calculated SUV, AmyDV, and TAU using a quantitative analysis software program for bone SPECT (GI-BONE) and analyzed AmyDV using two methods: threshold method (set 40%); and constant value method (average SUV of ribs). We assessed the diagnostic ability of heart-to-contralateral lung (H/CL) ratio, SUV, AmyDV, and TAU to differentiate ATTR from non-ATTR using receiver operating characteristic (ROC) analysis. Statistically significant differences in all quantitative indices were observed between ATTR and non-ATTR. The area under the curve of each quantitative index for discriminating between ATTR and non-ATTR were as follows: H/CL, 0.997; SUV, 0.953; SUV (M1), 0.964; SUV (M2), 0.969; AmyDV (M1), 0.875; AmyDV (M2), 0.974; and TAU, 0.974. The AmyDV (M2) had higher diagnostic ability than AmyDV (M1). Thus, TAU was calculated as AmyDV (M2) × SUV (M2). In the ROC curve, SUV, AmyDV, and TAU had almost the same diagnostic ability as H/CL in distinguishing ATTR from non-ATTRs. We propose two novel 3D-based quantitative parameters (AmyDV and TAU) that have almost equal ability to discriminate ATTR from non-ATTR.

1. (英) Article.ELocationID: 10.1007/s11604-022-01364-0

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) KeywordList.Keyword: Amyloid deposition volume (AmyDV)

4. (英) KeywordList.Keyword: Becquerel calibration factor (BCF)

5. (英) KeywordList.Keyword: Cardiac amyloidosis (CA)

6. (英) KeywordList.Keyword: Standardized uptake value (SUV)

7. (英) KeywordList.Keyword: Total amyloid uptake (TAU)